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Nationwide study compares surgeries to treat urinary incontinence in women

The University of California, San Diego Medical Center along with nine other clinical research institutions across the United States has completed the largest randomized clinical trial to date comparing two commonly performed surgical procedures to treat urinary stress incontinence.

Findings reveal that a procedure that places a sling to support the bladder is significantly more effective than another common technique, called the Burch, which secures the urethra and bladder to the pelvic wall with sutures. The multi-center study, supported by the National Institutes of Health, is published in the May 24 New England Journal of Medicine print edition.

Known as SISTEr, the Stress Incontinence Surgical Treatment Efficacy Trial compared the fascial sling with the Burch colposuspension technique for treating stress urinary incontinence which occurs during coughing, laughing, sneezing, running or lifting heavy objects, causing urine to leak. The condition develops when the normal support structures of the urethra and bladder are weakened, causing the bladder to move down toward the bottom of the pelvis.

In the sling procedure, a strip of the patients own tissue is placed under the urethra like a hammock and attached to the ligaments of the pubic bone to provide support. In the Burch procedure, the urethra and bladder are lifted back into their normal position and secured to tissue near the pubic bone with sutures. Both procedures provide additional support to the urethra during periods of activity to prevent urine leakage.

655 women were randomly assigned to the study: 326 to undergo the sling procedure and 329 to undergo the Burch procedure; 520 women completed the outcome assessment. Two years after surgery, overall success rates were 47 percent and 38 percent for the sling and Burch groups, respectively. Although the sling procedure may offer higher cure rates, this advantage may be offset by complications such as urinary tra
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Contact: Jackie Carr
jcarr@ucsd.edu
619-543-6163
University of California - San Diego
21-May-2007


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