HOME >> MEDICINE >> NEWS
Neural transplants provide persistent benefit in patients with Huntington's disease

Neuronal transplantation in Huntington's disease provides a period of improvement and stability of several years, according to an Article published online today (Monday February 27, 2006) by The Lancet Neurology.

Intracerebral cell therapy, which aims to substitute striatal neurons lost to Huntington's disease by striatal neuroblasts and neural precursors obtained from embryos after elective abortion, has proven beneficial in patients with the disease. Theoretical projection models suggest that the clinical effects of grafting will lead to an initial improvement followed by a period of secondary decline due to the ongoing disease process. However, follow-up has not been long enough to assess the duration of clinical benefit of the treatment up to now.

Anne-Catherine Bachoud-Lvi (Henri Mondor Hospital, France) and colleagues have previously shown, in a pilot study, that intracerebral neural grafts lead to motor and cognitive improvement in patients with Huntington's disease 2 years after the procedure. In their current article, they present data for five patients from their pilot study, assessed annually for up to 6 years after neural grafting.

The procedure provided long-term clinical benefits to three patients in parallel with long-lasting focal improvement in brain metabolic activity. Progression of the disease led to heterogeneous secondary clinical alterations and changes of cerebral metabolism.

Whereas neuronal transplantation is not a permanent cure for Huntington's disease, it does provide a period of improvement and stability. Although neuroprotective treatment seems to be unavoidable in the disease, improvement of the surgical procedure and in patient selection could improve the therapeutic value of neuronal transplantation. Bachoud-Lvi concludes: "Neuroprotection could stop the disease, but only a graft can restore lost function."


'"/>

Contact: Joe Santangelo
j.santangelo@elsevier.com
212-633-3810
Lancet
26-Feb-2006


Page: 1

Related medicine news :

1. Neural networking nanotubes
2. Neural development protein disproved as marker for schizophrenia
3. Neural cell transplants fight immune attack in mice with multiple sclerosis
4. Thymus transplants gives hope to babies with fatal immune disease
5. Outcomes for patients with hepatitis B who need liver transplants
6. Women given liver transplants outlive male recipients by around 4 years
7. How tumors respond to treatment prior to liver transplants may be useful in selecting recipients
8. National trial gives unprecedented support for steroid withdrawal in kidney transplants
9. Organ transplants just as successful in those with mental retardation
10. Liver transplants can be successful in HIV patients with Hepatitis B
11. Stem cell transplants improve recovery in animal models for stroke, cerebral palsy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... Pa. (PRWEB) , ... October 13, 2017 , ... While ... dark poses a problem. Fortunately, an inventor from Austin, Texas, has identified a solution. ... to medication in darkness or restricted lighting. As such, it eliminates the need to ...
(Date:10/13/2017)... ... October 13, 2017 , ... Southern ... and Jennifer Huggins, PharmD ’17, along with clinical associate professor Janice Frueh, ... cardiovascular diseases during the 15th Annual Women’s Health Conference. The SIU School ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... The Visiting ... Day Market. Featuring a collection of specialty vendors and unique items from across the ... and quality-focused health and wellness services offered by the VNA. The boutique will ...
(Date:10/13/2017)... ... 13, 2017 , ... Talented host, actor Rob Lowe, is ... a new episode of "Success Files," which is an award-winning educational program broadcasted ... each subject in-depth with passion and integrity. , Sciatica occurs when the sciatic ...
(Date:10/12/2017)... ... 2017 , ... First Healthcare Compliance (FHC), an industry leader ... range of technology and learning solutions at the 68th Annual American Healthcare Association ... held October 14–18, 2017 at the Mandalay Bay Resort in Las Vegas, Nevada. ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... 2017  BioPharmX Corporation (NYSE MKT: BPMX) researchers were ... innovative way to use nonlinear optical imaging to confirm ... drugs. A ... show how researchers from BioPharmX and the Wellman Center ... a suite of imaging techniques in what is called ...
(Date:10/11/2017)... 11, 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), ... in Las Piedras, Puerto Rico , ... Following a ... sustained minor structural damage, temporary loss of power and ... been completed, manufacturing operations have resumed, and the company ...
(Date:10/7/2017)... Oct. 6, 2017   Provista, a proven ... $100 billion in purchasing power, today announced a new ... The Newsroom is the online home for ... infographics, expert bios, news releases, slideshows and events. ... a wealth of resources at their fingertips, viewers can ...
Breaking Medicine Technology:
Cached News: