HOME >> MEDICINE >> NEWS
New algorithm matches any tumor cells to best possible anti-cancer treatments

CHARLOTTESVILLE, Va., July 23, 2007 -- Cancer patients dont have time to waste. Many go through several different treatments, however, to find one that is more effective against their particular type of tumor.

Thus, an algorithm that could help rapidly sort molecular information about a patients particular tumor and could help match this information to the right drug treatment would be a breakthrough of enormous value. Dan Theodorescu, M.D., Ph.D., a University of Virginia oncologist and cancer biologist, and Jae Lee, Ph.D., a computational biologist and bioinformatics statistician, have pioneered just such a system. This work involved collaboration with colleagues at the National Cancer Institute, GeneLogic Inc. and the University of Virginia Computer Sciences Department. They published their results the week of July 23 in the Early Edition of the Proceeedings of the National Academy of Sciences, found online.

Using a panel of 60 diverse, human cancer cell lines from the National Cancer Institute (NCI-60), the researchers devised and tested an algorithm designed to match the best potential treatment(s) for a particular tumor in a particular patient.

Previously, the NCI-60 cell lines were used to screen more than 100,000 chemical compounds for their anticancer activity. These drug responses, however, were not definitely linked to clinical effectiveness in patients. Another issue is that the 60 cell lines did not include all important cancer types (for example, certain bladder cancers, lymphomas, and small cell lung cancers were not among the 60 lines studied).

The researchers investigated whether the drug sensitivity data of the 60 cancer cell lines could be extrapolated into useful information on other tumors or cancer cell lines. In fact, they found that their coexpression extrapolation (COXEN) system could be used to accurately predict drug sensitivity for bladder cancer cell lines to two common chemotherapies, cis
'"/>

Contact: Mary Jane Gore
mjgore@virginia.edu
434-924-9241
University of Virginia Health System
23-Jul-2007


Page: 1 2 3

Related medicine news :

1. Emory algorithm improves kidney transplant chances for sensitized patients
2. New strategy could increase number of kidney transplant matches
3. Blood-based TB test matches up to old skin test in study among health workers in India
4. Kidney donation program may provide more matches for previously incompatible recipients and donors
5. Study shows radiofrequency ablation highly effective in treating kidney tumors
6. First of its kind report on how children with brain tumors perform at school
7. Progress toward an antitumor vaccine
8. Folic acid supplements do not appear to reduce risk of colorectal tumors
9. USC researchers show that molecular markers predict tumor recurrence
10. Trial shows circulating tumor cells predict how prostate cancer patients do with chemotherapy
11. Chemotherapy may enhance the effectiveness of brain tumor vaccines

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/3/2020)... ... September 03, 2020 , ... ... sponsoring the American Foundation for Suicide Prevention’s (AFSP) annual signature event, Out of ... across hundreds of U.S. cities to raise awareness of suicide prevention. To ensure ...
(Date:9/3/2020)... ... September 03, 2020 , ... ... for Sunrise Technologies WALI wireless parking lot controller. This advanced LED wireless dimming ... reducing light trespass, and protecting the night sky against light pollution. Leo Smith, ...
(Date:9/1/2020)... ... September 01, 2020 , ... Feeding Matters , the first organization ... Feeding Disorder (PFD), is pleased to announce that the U.S. Centers for Disease Control ... code) in the next edition of the U.S. International Classification of Diseases (ICD ...
(Date:8/31/2020)... ... 31, 2020 , ... The Lymphoma Research Foundation (LRF) ... research and serving the lymphoma community through a comprehensive series of education programs, ... Cancer Awareness Month (BCAM) and its international Light it Red for Lymphoma ...
(Date:8/31/2020)... ... August 31, 2020 , ... Genesis Chiropractic Software ... today the launch of its integrated, HIPAA compliant, telehealth solution, available to US-based ... in under 90 seconds. , According to the U.S. Department of Health ...
Breaking Medicine News(10 mins):
(Date:8/26/2020)... , ... August 26, 2020 , ... ... CHPN, CHPCA, LNC has added CHC and CPCO to her name. , That’s ... in Healthcare Compliance (CHC) and the Certified Professional Compliance Officer (CPCO.) , The ...
(Date:8/26/2020)... (PRWEB) , ... August 26, 2020 , ... ... largest non-profit organization devoted to funding innovative lymphoma research and serving the lymphoma ... 25th Anniversary with a special virtual LRF Gala and Charity Auction on ...
(Date:8/26/2020)... ... 26, 2020 , ... Sudden pain anywhere in the body typically makes us stop what we’re ... back pain due to a problem in your spine, or something else? , The short ... , Low back pain is so prevalent that it’s the second most common reason Americans ...
Breaking Medicine Technology:
Cached News: