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New analytical techniques developed to quantify composition of fake anti-malarials

Researchers led by the Georgia Institute of Technology are developing novel analytical chemistry techniques to detect and quantify the contents of counterfeit anti-malarial drugs and other fake pharmaceuticals. The manufacture and distribution of these fake medications is a growing problem in third-world countries, where the mosquito-borne illness malaria is widespread.

A report on this research funded by the Society of Analytical Chemists of Pittsburgh and the Wellcome Trust of Great Britain -- will be published this summer in the journal ChemMedChem.

Georgia Tech Assistant Professor of Chemistry and Biochemistry Facundo Fernandez began studying counterfeit anti-malarials two years ago using conventional analytical chemistry techniques based on liquid chromatography and mass spectrometry. But these methods required more than two hours to analyze just one sample. So he and his graduate students developed new, high-throughput ionization techniques that now allow them to complete the same analytical analyses in just five seconds per sample.

"This is a new generation of techniques in mass spectrometry," Fernandez said. "We don't probe our samples under vacuum like you normally do with mass spectrometry. We can hold a solid sample under atmospheric pressure and use one of our new tools to ionize its surface components. The ionized particles are subsequently analyzed by mass spectrometry. This method eliminates the time and costs associated with sample preparation."

Specifically, Fernandez and his students have worked to improve two recently developed analytical chemistry techniques desorption electrospray ionization (DESI) developed by Purdue University and direct analysis in real time (DART) developed by the Japanese company JEOL.

The researchers use DESI to screen anti-malarials to quantify the amount of the active ingredient artesunate in counterfeits. In DESI, researchers use a high-speed, charged spray containing alcoho
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Contact: John Toon
jtoon@gatech.edu
404-894-6986
Georgia Institute of Technology Research News
13-Jun-2006


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