HOME >> MEDICINE >> NEWS
New class of targeted cancer drugs shows promise in slowing progression of recurrent prostate cancer

A new class of targeted anti-cancer drugs that blocks the human epidermal growth factor (HER) receptor family shows promise in prolonging the lives of patients with recurrent prostate cancer, a new Cedars-Sinai study shows. The drug, a molecular targeted compound called pertuzumab, works by binding to and inhibiting the function of HER2 receptors, interrupting a key pathway that leads to cancer growth.

The study, published in the February 20 issue of the Journal of Clinical Oncology, involved 41 patients with treatment-resistant prostate cancer who had experienced progression of their disease after prior chemotherapy. Patients received the drug every three weeks until disease progression. MRI and CAT scans were used to evaluate the tumors during the period of drug therapy. While no shrinkage of tumors was reported, retrospective analysis showed that survival rate was prolonged to 16.4 months with the drug as compared to a median average of 10.7 months in a historical control group with similar baseline prognostic features.

Advanced prostate cancer is difficult to treat and the drug therapies currently available to these patients have not been very effective, especially in patients whose disease has progressed after chemotherapy treatment, said David B. Agus, M.D., principal investigator of the study and research director of Cedars-Sinais Louis Warschaw Prostate Cancer Center at the Samuel Oschin Comprehensive Cancer Institute. Pertuzumab may offer a new treatment approach for these patients when it is evaluated as a tool to slow not stop or shrink -- tumor growth.

The theory is that by significantly slowing progression of the cancer, patients will experience a good quality of life for a longer period of time, said Agus. Ultimately, we hope drugs like pertuzumab will help us reach the point where cancer can be viewed as a lifetime disease to be managed much like AIDS is looked at now. This would be major shift from the current
'"/>

Contact: Simi Singer
simi.singer@cshs.org
310-423-4768
Cedars-Sinai Medical Center
16-Feb-2007


Page: 1 2 3

Related medicine news :

1. W.M. Keck Foundation announces 2007 class of Distinguished Young Scholars in medical research
2. Early-morning Friday classes may prevent students from getting sloppy on thirsty Thursdays
3. Panel offers guidelines on skin reactions to new class of cancer drugs
4. UK researchers find new class of nontoxic cancer treatments
5. New class of HIV drug attacks previously untargeted enzyme
6. Sleep disturbances affect classroom performance
7. Simple classification can help define and predict limb-threatening diabetic infections
8. World-class Biomedical Research Center to be in West London
9. A new way of classifying addictive drugs
10. Phys ed class more effective when theres more talking
11. W.M. Keck Foundation announces 2006 class of Distinguished Young Scholars in Medical Research

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... ... August 31, 2020 , ... Genesis Chiropractic Software and ... the launch of its integrated, HIPAA compliant, telehealth solution, available to US-based clients ... under 90 seconds. , According to the U.S. Department of Health & ...
(Date:8/31/2020)... ... August 31, 2020 , ... A Cure for Covid-19 “PTS” with Mediation & Hypnosis , ... in a state of panic, experiencing deep anxiety, immense stress, and right now are needing ... timely when most people on the planet are experiencing a great degree of emotional discomfort, ...
(Date:8/29/2020)... ... August 29, 2020 , ... When professor and author Randy Pausch was ... most people would. Rather than become melancholic, however, he put together a final lecture ... dreams. Randy Pausch took a negative situation and turned it into something that inspired ...
(Date:8/28/2020)... ... August 28, 2020 , ... With ... set out to continue helping the specialty-diet community connect with great, gluten-free brands. ... get coupons, enter giveaways, chat with brands & watch over 50 educational classes... ...
(Date:8/27/2020)... ... August 27, 2020 , ... Walk-in Dermatology’s SK-IN Medical Aesthetics ... Greenvale, New York location. , Loren received her New York esthetic license ... in chemical peels, microdermabrasion, Hydrafacial MD, dermaplaning, facial lymphatic, and various laser procedures. ...
Breaking Medicine News(10 mins):
(Date:9/2/2020)... ... September 02, 2020 , ... Rigaku Analytical ... roundtable discussion among industry professionals about successes and challenges of making changes to ... Pharmaceutical Review and will take place on October 15, 2020 at 10:00am ...
(Date:9/1/2020)... ... September 01, 2020 , ... Agilent, a ... Agilent Science and Technology Virtual Symposium 2020 (ASTVS 2020) on September ... a suite of Live webinars and Networking sessions, with a vast array of ...
(Date:9/1/2020)... N.C. (PRWEB) , ... September 01, 2020 , ... While ... an alarming rate as businesses, schools and community organizations remain closed. Because about 80% ... urgently needs the help of both blood donors and blood drive hosts to ensure ...
Breaking Medicine Technology:
Cached News: