HOME >> MEDICINE >> NEWS
New class of targeted cancer drugs shows promise in slowing progression of recurrent prostate cancer

A new class of targeted anti-cancer drugs that blocks the human epidermal growth factor (HER) receptor family shows promise in prolonging the lives of patients with recurrent prostate cancer, a new Cedars-Sinai study shows. The drug, a molecular targeted compound called pertuzumab, works by binding to and inhibiting the function of HER2 receptors, interrupting a key pathway that leads to cancer growth.

The study, published in the February 20 issue of the Journal of Clinical Oncology, involved 41 patients with treatment-resistant prostate cancer who had experienced progression of their disease after prior chemotherapy. Patients received the drug every three weeks until disease progression. MRI and CAT scans were used to evaluate the tumors during the period of drug therapy. While no shrinkage of tumors was reported, retrospective analysis showed that survival rate was prolonged to 16.4 months with the drug as compared to a median average of 10.7 months in a historical control group with similar baseline prognostic features.

Advanced prostate cancer is difficult to treat and the drug therapies currently available to these patients have not been very effective, especially in patients whose disease has progressed after chemotherapy treatment, said David B. Agus, M.D., principal investigator of the study and research director of Cedars-Sinais Louis Warschaw Prostate Cancer Center at the Samuel Oschin Comprehensive Cancer Institute. Pertuzumab may offer a new treatment approach for these patients when it is evaluated as a tool to slow not stop or shrink -- tumor growth.

The theory is that by significantly slowing progression of the cancer, patients will experience a good quality of life for a longer period of time, said Agus. Ultimately, we hope drugs like pertuzumab will help us reach the point where cancer can be viewed as a lifetime disease to be managed much like AIDS is looked at now. This would be major shift from the current
'"/>

Contact: Simi Singer
simi.singer@cshs.org
310-423-4768
Cedars-Sinai Medical Center
16-Feb-2007


Page: 1 2 3

Related medicine news :

1. W.M. Keck Foundation announces 2007 class of Distinguished Young Scholars in medical research
2. Early-morning Friday classes may prevent students from getting sloppy on thirsty Thursdays
3. Panel offers guidelines on skin reactions to new class of cancer drugs
4. UK researchers find new class of nontoxic cancer treatments
5. New class of HIV drug attacks previously untargeted enzyme
6. Sleep disturbances affect classroom performance
7. Simple classification can help define and predict limb-threatening diabetic infections
8. World-class Biomedical Research Center to be in West London
9. A new way of classifying addictive drugs
10. Phys ed class more effective when theres more talking
11. W.M. Keck Foundation announces 2006 class of Distinguished Young Scholars in Medical Research

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/21/2017)... ... September 21, 2017 , ... Bill Howe Plumbing’s mission is to ... give back to the community. For over 37 years, they have operated with their ... plumbing in San Diego. They were chosen as the Best San Diego ...
(Date:9/21/2017)... , ... September 21, 2017 , ... The New England ... autism, announced today the election of Yie-Hsin Hung to the Board of Directors. ... our Board of Directors. Ms. Hung is an invaluable addition to our team,” said ...
(Date:9/21/2017)... ... 21, 2017 , ... A new addiction treatment service has ... when Virginia faces an opioid epidemic. , Last year, Virginia saw ... percent from 2015, underscoring the need for additional addiction treatment options. , Calyx ...
(Date:9/21/2017)... ... September 21, 2017 , ... ... serving communities in northern Alabama and Georgia, is embarking on an extended charity ... utilizing modern early detection methods. , US Breast Cancer statistics show that ...
(Date:9/20/2017)... ... 2017 , ... FirstAlign ( http://www.firstalign.com ), combines strategies and ... (AI) thinking, announced today the launch of its revamped web presence. , ... offers a more comprehensive understanding of the organization’s business and machine learning solutions. ...
Breaking Medicine News(10 mins):
(Date:9/9/2017)... , Sept. 8, 2017 ... Mobile MRI Unit coming to Washington DC ... When: Tuesday, September 12 th – Monday, September ... Washington, D.C. offering free MRI brain scans to the public.Where:  ... will be parked at 501 K Street NW, Washington, D.C.What:BTF brings its ...
(Date:9/7/2017)... , Sept. 7, 2017  Eli Lilly and ... actions to streamline operations to more efficiently focus ... its cost structure. Global workforce reductions, including those ... expected to impact approximately 3,500 positions. ... expects annualized savings of approximately $500 million that ...
(Date:9/7/2017)... 7, 2017 NuvoAir (formerly called Pond ... today a partnership with Novartis Pharma AG to distribute NuvoAir,s ... as the leading mobile spirometry platform and Novartis, commitment to ... ... ...
Breaking Medicine Technology:
Cached News: