HOME >> MEDICINE >> NEWS
New class of targeted cancer drugs shows promise in slowing progression of recurrent prostate cancer

paradigm for cancer treatment, and is a promising area of research. This study must be viewed cautiously, however, as we are comparing statistics from historical control groups.

Pertuzumab is a single-agent antibody designed to bind to the HER2 receptor and inhibit the ability of HER2 to pair with other HER family members (HER1, HER2, HER3 and HER4). If the pairing process (called dimerization) is not interrupted, the binding of these growth factors activates an intracellular signaling pathway that leads to tumor proliferation.

While other drugs such as docetaxel have shown to benefit men with advanced prostate cancer, no other second-line therapy (a treatment given when an initial treatment (first-line therapy) does not work or stops working) to date has shown to prolong survival.

Previous research published by cancer researchers at Cedars-Sinai and other institutions has shown that pertuzumab affects the growth of several other types of cancers, including breast, ovarian and lung cancer, and that the drug may also prolong survival for patients with advanced ovarian cancer.

In the current study, the pertuzumab was well-tolerated but no objective tumor shrinkages were observed. No decline in PSA (prostate-specific antigen; a tumor marker) levels was detected in patients during the study. According to the researchers, this study raises a question long debated in prostate cancer literature: what should clinical outcome standards or end point be the for studies involving patients with advanced, intractable prostate cancer who have limited treatment options.

The next step for researchers is to test the pertuzumab on a larger group of patients in a randomized fashion, and to analyze data that is not retrospective.

Prostate cancer is the most common type of cancer found in American men, other than skin cancer and is the second leading cause of cancer death in men. The American Cancer Society estim
'"/>

Contact: Simi Singer
simi.singer@cshs.org
310-423-4768
Cedars-Sinai Medical Center
16-Feb-2007


Page: 1 2 3

Related medicine news :

1. W.M. Keck Foundation announces 2007 class of Distinguished Young Scholars in medical research
2. Early-morning Friday classes may prevent students from getting sloppy on thirsty Thursdays
3. Panel offers guidelines on skin reactions to new class of cancer drugs
4. UK researchers find new class of nontoxic cancer treatments
5. New class of HIV drug attacks previously untargeted enzyme
6. Sleep disturbances affect classroom performance
7. Simple classification can help define and predict limb-threatening diabetic infections
8. World-class Biomedical Research Center to be in West London
9. A new way of classifying addictive drugs
10. Phys ed class more effective when theres more talking
11. W.M. Keck Foundation announces 2006 class of Distinguished Young Scholars in Medical Research

Post Your Comments:
(Date:11/21/2014)... The typical Thanksgiving dinner table is ... of gravy and a myriad of mouthwatering desserts. Who ... of year to begin losing weight? Listen closely. With ... secret to losing unhealthy, embarrassing and uncomfortable fat while ... The insight to Diet Doc’s calorie loading holiday ...
(Date:11/21/2014)... Florida (PRWEB) November 21, 2014 TruDenta, ... chronic headaches and other jaw-related symptoms, has ... seeking relief from chronic head pain, neck pain, TMJ ... , “This year we have seen a 52% increase ... Our network of over 300 doctors and their teams ...
(Date:11/21/2014)... Even with years of experience under his belt, Kirk ... growth, participating in two recent events for his State Farm ... networking event with the leaders of State Farm and thousands ... and greatest in insurance news and products for his clients. ... (Stacy, Anthony, Reina and Jacob) as exhibitors at the recent ...
(Date:11/21/2014)... 2014 First Choice Emergency Room ... The new facility is located at 225 E. Parkwood ... “We are pleased to join the Friendswood community and ... care here,” said Dr. Siddiqi, Facility Medical Director of ... celebrate the opening, First Choice Emergency Room made a ...
(Date:11/21/2014)... HealthDay Reporter THURSDAY, Nov. 20, 2014 ... of a still-beating heart has the potential to improve the ... new study. Heart patients who received the gel implant ... hundreds of feet farther during a six-minute walk test, said ... cardiovascular division at Washington University School of Medicine and a ...
Breaking Medicine News(10 mins):Health News:Diet Doc Releases New Calorie Loading Diet Plans - the Perfect Way to Jump Start the Metabolism and Begin Weight Loss During Thanksgiving 2Health News:Diet Doc Releases New Calorie Loading Diet Plans - the Perfect Way to Jump Start the Metabolism and Begin Weight Loss During Thanksgiving 3Health News:Diet Doc Releases New Calorie Loading Diet Plans - the Perfect Way to Jump Start the Metabolism and Begin Weight Loss During Thanksgiving 4Health News:National Rise In Patients Seeking Headache Relief 2Health News:Kirk Martin Insurance Agency Goes Local and National with State Farm 2Health News:First Choice Emergency Room Opens New Facility in Friendswood, Texas 2Health News:Gel Implant Might Help Fight Heart Failure 2Health News:Gel Implant Might Help Fight Heart Failure 3
(Date:11/21/2014)... NEW YORK , Nov. 20, 2014  Market research ... as the "Year of The Buy, in the medical ... market for medical devices will produce just 3% growth ... competitive actions, including acquisitions of product lines and entrance ... an annual survey of medical devices, The Global ...
(Date:11/21/2014)... Nov. 20, 2014  The acceptance of two ... AAGL Global Congress demonstrates continued interest in the ... provide bowel control. One of the abstracts, presented by ... Division Chief of Urogynecology and Reconstructive Pelvic Surgery ... Award for Best Written Abstract on Urogynecology/Pelvic Floor ...
(Date:11/21/2014)... Nov. 20, 2014 Oxis International, Inc. (OXIS) (OXI.PA) ... election of Anthony J. Cataldo as Chief Executive ... Effective November 19, 2014, Ken Eaton resigned his ... of Directors of Oxis International, Inc. to pursue new opportunities. ... named Chief Executive Officer of Oxis International, Inc. Mr. Cataldo ...
Breaking Medicine Technology:Kalorama: 2014 The "Year of The Buy" in Medical Device Industry 2LIFE Study Prominently Featured at Minimally Invasive Gynecology Conference 2LIFE Study Prominently Featured at Minimally Invasive Gynecology Conference 3OXIS International, Inc. announces Changes in Management Team 2OXIS International, Inc. announces Changes in Management Team 3
Cached News: