HOME >> MEDICINE >> NEWS
New clues into causes of scleroderma

sease that we can use to potentially slow down or reverse the process of tissue damage."

One of the most characteristic effects of the disease is the gradual formation of fibrotic tissue, which leaves patients with disfiguring and painful tightening of the skin. Additionally, the disease tends to slowly destroy small blood vessels and capillaries, which are not only present in skin, but also in internal organs, leaving them vulnerable to function failure.

It is known that the excessive fibrosis seen in scleroderma patients is in part the result of an inappropriate activation of transforming growth factor-beta (TGF-beta), a substance called a cytokine that regulates the intensity and duration of the immune response. Too much TGF-beta activity can occur in the presence of destabilized microtubules, which give structural support to cells and are involved in the movement of genetic material during cell division. When microtubules become destabilized, a complex process ensues which leads to the excessive TGF-beta pathway activation, and consequent accumulation of collagen, the primary component of fibrotic tissue.

"We've learned in our previous studies that the treatment of individual cells with paclitaxel helps stabilize microtubules, thereby blocking the excessive activity of TGF-beta," Dong explained. "So in our latest studies, we were interested in determining whether or not paclitaxel would have any effect on tissue with scleroderma."

For their experiments, the Duke team used mice bred to have no immune system. They transplanted skin samples from humans with and without scleroderma onto the backs of these mice. Some of the skin samples were pre-treated for 30 minutes with paclitaxel.

"We found that the skin samples from scleroderma patients that were pre-treated with paclitaxel prior to transplantation significantly suppressed the activity of TGF-beta and lessened the formation of fibrotic tissue," Dong said.

Just as i
'"/>

Contact: Richard Merritt
Merri006@mc.duke.edu
919-684-4148
Duke University Medical Center
31-Oct-2005


Page: 1 2 3 4

Related medicine news :

1. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
2. Cars imaging reveals clues to myelin damage
3. Tumor cell activity may provide clues for treating breast cancer in young women
4. Stem cells provide clues to cancer spread
5. Study offers clues to Broken Heart Syndrome
6. Study offers new clues to brain-stomach interaction in overeating
7. Mouse study reveals new clues about virulence of 1918 influenza virus
8. St. Jude finds clues to hearing loss from chemotherapy
9. JAMA study provides clues to cause of sudden cardiac death in teens
10. Neurobiology of dread gives scientists clues about human decision making
11. New MRI clues identify stroke victims at risk of skull hemorrhaging

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New clues into causes scleroderma

(Date:11/24/2014)... PA (PRWEB) November 24, 2014 ... Nataliya Ternopolska, MD has joined The Neurology Group ... Health’s Multiple Sclerosis Center. , A graduate of ... in Neurology at Albert Einstein Medical Center in Philadelphia ... Judith Jaffe Multiple Sclerosis Center at Weill Cornell Medical ...
(Date:11/24/2014)... (PRWEB) November 24, 2014 Olaparib functions ... polymerase (PARP) and is one of the first PARP ... to creating some types of melanoma, and are often ... also sometimes gives their malignancies a exclusive weaknesses, as ... to fix their DNA and allow them to proceed ...
(Date:11/24/2014)... SWAccessControl.com has recently released a new collection ... the company is a leading online supplier in the international ... available at discounted prices, up to 30% off. , “We ... This time, all of our items are offered at low ... so I have confidence in our fresh assortment. You will ...
(Date:11/24/2014)... CA (PRWEB) November 24, 2014 SafeHandles™ ... episode of Innovations with Ed Begley Jr, airing via ... was created to provide a passive, non-invasive, replaceable, and ... how SafeHandles™ incorporates custom-fit shrinkable sleeves and adhesives to ... , “At the core of SafeHandles is the ...
(Date:11/24/2014)... (PRWEB) November 24, 2014 Dr. Michael ... Fertility Center, recently appeared on NBC to discuss egg freezing ... freezing has been trending in the news recently, with new ... procedure for women. , “[The companies] see it ... are on a career hot path.” Says Dr. Kettel. , ...
Breaking Medicine News(10 mins):Health News:Nataliya Ternopolska Named Associate Medical Director of Abington Health’s Multiple Sclerosis Center 2Health News:Olaparib Industry (CAS 763113-22-0) 2009-2019 Global and China Research Reports is Now Available at RnRMarketResearch.com 2Health News:Olaparib Industry (CAS 763113-22-0) 2009-2019 Global and China Research Reports is Now Available at RnRMarketResearch.com 3Health News:Olaparib Industry (CAS 763113-22-0) 2009-2019 Global and China Research Reports is Now Available at RnRMarketResearch.com 4Health News:SWAccessControl.com Is Happy To Release New Range Of Magnetic Locks 2Health News:New Episode of Innovations TV Series to Feature SafeHandles™ 2Health News:Dr. Michael Kettel of San Diego Fertility Center Gives “An Inside Look at Freezing Eggs” on NBC 2Health News:Dr. Michael Kettel of San Diego Fertility Center Gives “An Inside Look at Freezing Eggs” on NBC 3
(Date:11/24/2014)... 24, 2014  Surgical Theater, LLC, announced today that ... th opening of Europe,s ... "C. Besta." The SuRgical Planner (SRP) and the Surgical ... event for their 3D navigation and augmented reality capabilities ... , Professor and Chair, Department of Neurosurgery at Mount ...
(Date:11/24/2014)...  Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL ) today ... board of directors and from his positions as chairman and ... serving as the company,s president and chief operating officer, will ... board of directors.  Gary Lyons , a member of ... Gower is expected to remain an employee until the end ...
(Date:11/24/2014)... Nov. 24, 2014  Pifflers United Chronic and ... the release of results of a study of ... the self-management of fibromyalgia pain. The results demonstrated ... pain, very significant clinically meaningful pain reduction can ... members with fibromyalgia used ActiPatch® for 7 days ...
Breaking Medicine Technology:Surgical Theater's Technology to be Showcased at the Opening of the Besta NeuroSim Center in Milan, Italy 2Surgical Theater's Technology to be Showcased at the Opening of the Besta NeuroSim Center in Milan, Italy 3Rigel Announces Executive Management Changes 2Rigel Announces Executive Management Changes 3Pifflers United - "Supporting Anyone Living With Chronic/Invisible Illness" Reports ActiPatch Bioelectronic Therapy Relieves Chronic Pain In Fibromyalgia 2Pifflers United - "Supporting Anyone Living With Chronic/Invisible Illness" Reports ActiPatch Bioelectronic Therapy Relieves Chronic Pain In Fibromyalgia 3
Cached News: