HOME >> MEDICINE >> NEWS
New clues into causes of scleroderma

sease that we can use to potentially slow down or reverse the process of tissue damage."

One of the most characteristic effects of the disease is the gradual formation of fibrotic tissue, which leaves patients with disfiguring and painful tightening of the skin. Additionally, the disease tends to slowly destroy small blood vessels and capillaries, which are not only present in skin, but also in internal organs, leaving them vulnerable to function failure.

It is known that the excessive fibrosis seen in scleroderma patients is in part the result of an inappropriate activation of transforming growth factor-beta (TGF-beta), a substance called a cytokine that regulates the intensity and duration of the immune response. Too much TGF-beta activity can occur in the presence of destabilized microtubules, which give structural support to cells and are involved in the movement of genetic material during cell division. When microtubules become destabilized, a complex process ensues which leads to the excessive TGF-beta pathway activation, and consequent accumulation of collagen, the primary component of fibrotic tissue.

"We've learned in our previous studies that the treatment of individual cells with paclitaxel helps stabilize microtubules, thereby blocking the excessive activity of TGF-beta," Dong explained. "So in our latest studies, we were interested in determining whether or not paclitaxel would have any effect on tissue with scleroderma."

For their experiments, the Duke team used mice bred to have no immune system. They transplanted skin samples from humans with and without scleroderma onto the backs of these mice. Some of the skin samples were pre-treated for 30 minutes with paclitaxel.

"We found that the skin samples from scleroderma patients that were pre-treated with paclitaxel prior to transplantation significantly suppressed the activity of TGF-beta and lessened the formation of fibrotic tissue," Dong said.

Just as i
'"/>

Contact: Richard Merritt
Merri006@mc.duke.edu
919-684-4148
Duke University Medical Center
31-Oct-2005


Page: 1 2 3 4

Related medicine news :

1. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
2. Cars imaging reveals clues to myelin damage
3. Tumor cell activity may provide clues for treating breast cancer in young women
4. Stem cells provide clues to cancer spread
5. Study offers clues to Broken Heart Syndrome
6. Study offers new clues to brain-stomach interaction in overeating
7. Mouse study reveals new clues about virulence of 1918 influenza virus
8. St. Jude finds clues to hearing loss from chemotherapy
9. JAMA study provides clues to cause of sudden cardiac death in teens
10. Neurobiology of dread gives scientists clues about human decision making
11. New MRI clues identify stroke victims at risk of skull hemorrhaging

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/26/2017)... ATLANTA, Ga. (PRWEB) , ... July 26, 2017 , ... ... and equal access to medicine for everyone affected by diabetes, is excited to announce ... of its Global Ambassador Program. , Established in 2005, the Team Type 1 ...
(Date:7/26/2017)... , ... July 26, 2017 , ... IDC-Eating Disorder ... Director for the treatment program located in Royal Oak, Michigan. IDC, formerly ... who are focused on providing the highest standards in the field of eating disorder ...
(Date:7/26/2017)... , ... July 26, 2017 , ... Wendy M. Musielak, a partner at ... elected as DuPage County Bar Association’s third Vice President earlier this year. She will serve ... office of the second Vice President, in accordance with the organization’s by-laws. , Musielak ...
(Date:7/25/2017)... ... ... “Now Hiring!” is a popular phrase at Home Delivery Incontinent Supplies ... for over 30 consecutive years and now plans to hire more than 100 people ... and growth at HDIS, following the company’s acquisition by Fortune 1000 company Domtar. HDIS ...
(Date:7/25/2017)... ... July 25, 2017 , ... Creative Pharmacist ... to provide the Pharmacist eCare Plan to Computer-Rx pharmacies through the ... the ability to develop the Pharmacist eCare Plan, a shared document detailing a ...
Breaking Medicine News(10 mins):
(Date:7/12/2017)... 2017  Eli Lilly and Company (NYSE: LLY ... to resolve pending patent litigation in the U.S. District Court ... regarding the Cialis ® (tadalafil) unit dose patent. This ... As part of the agreement, Cialis exclusivity is now expected ... "The unit dose patent for Cialis is valid and ...
(Date:7/11/2017)... has awarded grants totaling more than $2 million to 16 ... Hemophilia Awards Program (BHAP). Four U.S. clinicians and researchers from ... Uniformed Services University of the Health Sciences in ... announced last night during a reception at the International Society ... Germany . ...
(Date:7/11/2017)... 11, 2017  Sysmex America, Inc., a leading ... equipment as well as middleware information systems technology, ... make quality assurance easier and more risk free ... known for the innovation that it delivers to ... quality assurance processes to a new level with ...
Breaking Medicine Technology:
Cached News: