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New compounds fight chronic symptoms of bowel disorders

LOS ANGELES (May 22, 2006) Symptoms of bowel disorders like irritable bowel syndrome and Crohn's disease can vary in function and severity. New studies presented today at Digestive Disease Week 2006 (DDW) are finding that long-term therapy with new compounds can sustain relief for these patients with symptoms ranging from constipation to inflammation. DDW is the largest international gathering of physicians and researchers in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery.

A Dose-Ranging, Double-Blind, Placebo-Controlled Study of Lubiprostone in Subjects with Irritable Bowel Syndrome and Constipation (c-IBS) [Abstract 131]

Irritable bowel syndrome (IBS) affects millions of people in America and is difficult to diagnose and treat effectively due to its variability of symptoms. Current therapies work on select patient populations, but are limited in efficacy and have significant side effects. In this study, researchers examine the use of a novel therapy as an effective and safe new option for IBS patients.

Lubiprostone, a novel type-2 chloride channel (ClC-2) activator, has shown positive results and good tolerability in previous trials of patients with chronic constipation. The therapy increases fluid secretion, which works to improve function in the gastrointestinal system. This study tested different doses of lubiprostone over 12 weeks in subjects with constipation-specific IBS (c-IBS), as defined by the Rome II Criteria, which outlines symptoms and applies parameters such as frequency and duration to more accurately diagnose IBS.

Approximately 50 patients were randomized to each of four treatment groups: placebo or 16, 32 or 48 g lubiprostone daily. Patients were asked to keep a log of their progress, including dose, abdominal symptoms like bloating and discomfort or pain, bowel movements (BMs) including frequency, straining, and consistency ratings, as well as the use of rescue med
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Contact: Aimee Frank
newsroom@gastro.org
301-941-2620
American Gastroenterological Association
22-May-2006


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