New data show OAB therapy Enablex® does not impair memory function compared to alternative

  • Subjects receiving other overactive bladder treatment failed to notice decline in their memory function
  • These data provide further information about Enablex, an effective overactive bladder treatment that has been available for more than a year

ATLANTA - Data from a head-to-head clinical study looking at the effects of two prescription medications used to treat overactive bladder (OAB) showed that treatment with Enablex (darifenacin) did not result in impaired memory function in healthy adults age 60 and older.(1) In contrast, treatment with Ditropan XL(i) (oxybutynin extended-release or ER), the other medication evaluated in the study, caused significant memory deterioration. Importantly, the individuals receiving oxybutynin ER failed to notice the change in their memory function. These findings were presented today during the 2006 Annual Meeting of the American Urological Association (AUA).

Enablex and Ditropan XL are indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency and frequency. Both therapies are antimuscarinic agents, meaning they act on muscarinic receptors in the body associated with bladder control.

"Beyond balancing efficacy, tolerability and safety, selecting an appropriate overactive bladder treatment requires consideration of possible cognitive effects. These data indicate that Enablex may be a good treatment option for the older population," stated Gary Kay, PhD, Washington Neuropsychological Institute and lead study investigator. "Clinical studies have demonstrated increased sensitivity of older subjects to antimuscarinics, including effects on memory; prompting us to conduct this clinical trial."

These data are analyses of results from a multi-center, randomized, double-blind, placebo-controlled, parallel-group, three-week study involving 150 healthy older adults (male and female 60). Results at three weeks suggest that Enablex (15m


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