New data show the efficacy of EQUETRO in patients with Bipolar I Disorder

Atlanta, Ga May 24, 2005 Shire Pharmaceuticals Group plc (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ) announced today that EQUETROTM (carbamazepine extended-release capsules) are effective in significantly reducing the manic symptoms in patients with Bipolar I Disorder previously taking valproate or lithium, according to a pooled analysis of two phase 3 trials, one of two posters about carbamazepine extended-release capsules presented today at a major medical meeting in Atlanta, Ga.

The FDA approved EQUETRO for the treatment of patients with acute manic and mixed episodes associated with Bipolar I Disorder. Individual studies estimate lifetime prevalence for Bipolar I Disorder at more than 2 million American adults, or between 0.6 to 3.3 percent for lifetime incidence.

"Carbamazepine extended-release capsules are an effective treatment option for patients with bipolar disorder," said Richard H. Weisler, M.D., adjunct professor of psychiatry at the University of North Carolina at Chapel Hill School of Medicine, adjunct assistant professor of psychiatry and behavioral sciences at Duke University Medical Center, and primary investigator of two carbamazepine extended-release capsule trials. "The advent of carbamazepine extended-release capsules as a treatment option is a significant milestone."

In a pooled analysis of placebo-controlled studies, patients taking EQUETRO who had been previously taking valproate or lithium (both with or without improvement of their symptoms) showed significant reduction in manic symptoms based on a standard measure of Young Mania Rating Scale (YMRS). Specifically, patients previously taking valproate had a reduction in their average YMRS scores by 10.8 on EQUETRO vs. 5.7 on placebo (p=0.04), and those previously treated with lithium had a reduction in their average YMRS scores by 11.6 on EQUETRO vs. 4.0 on placebo (p=0.03). The analysis involved 115 patients from the two randomized, double blind placebo-controlled tri


Page: 1 2 3

Related medicine news :

1. Traditional Chinese exercises may increase efficacy of flu vaccine
2. International studies show high efficacy for HPV vaccine
3. 12-month study demonstrated tolerability and efficacy of Daytrana
4. Long-term treatment with VYVANSE, first prodrug stimulant, demonstrates significant efficacy in ADHD
5. MERLIN TIMI-36 study provides new safety and efficacy data for unique anti-anginal therapy
6. Studies led by Rhode Island Hospital confirm safety and efficacy
7. Malaria treatment efficacy compromised in certain HIV-positive patients
8. Treating obesity may improve the efficacy of therapy for hepatitis C
9. Four-year data suggest the CYPHER stent provides long-term efficacy and safety benefits
10. FDA expands indication for ADDERALL XR (CII) confirming safety and efficacy in adolescents
11. Fluctuating eye pressure associated with visual field deterioration in glaucoma patients

Post Your Comments:

(Date:3/30/2021)... , ... March 29, 2021 , ... ... the 21st Century , A Virtual Workshop Presented by WCG FDAnews and Cerulean ... 4:30 pm EDT, https://wcg.swoogo.com/modern-sop-and-quality-systems , Are one’s SOPs written for the ...
(Date:3/30/2021)... ... March 29, 2021 , ... According to data released ... reproductive age (13-44) in need of publicly funded contraception live in counties impacted by ... Colorado’s 64 counties have lost some of their Title X resources. , The ...
(Date:3/30/2021)... ... March 29, 2021 , ... Health Literacy Innovations (HLI), a ... confusion due to low health literacy today announces a new partnership with the ... work with ACAP’s member Safety Net Health Plans, those that provide comprehensive health ...
(Date:3/30/2021)... ... ... Dr. Colin Campbell is proud to announce the 1 year anniversary in their new state ... internal medicine and is a primary care specialist who has been practicing for 23 years. ... keep South Jersey healthy one patient at a time. , “Over the past year, Dr. ...
(Date:3/30/2021)... ... March 30, 2021 , ... The COVID-19 ... and survivors; their families; and their caregivers. Crossroads4Hope is addressing the needs of ... emotional support system, MyGo2Support, which meets needs of people impacted by cancer, no ...
Breaking Medicine News(10 mins):
(Date:3/30/2021)... ... March 29, 2021 , ... The University of Texas Health Science Center ... San Antonio Multispecialty and Research Hospital, a destination center for research and treatment of ... In a nod to the COVID-19 pandemic, the ceremony was held virtually. , William ...
(Date:3/30/2021)... ... March 29, 2021 , ... Iora Health ... primary care, has partnered with Devoted Health , one of the fastest-growing ... across Maricopa County and provides seniors with the highest-quality care and experience possible, ...
(Date:3/30/2021)... CITY (PRWEB) , ... March 29, 2021 , ... ... has joined the Vaccine Credential Initiative (VCI), a group bringing together leading health ... record of vaccination status, based on open, interoperable standards. By joining the VCI ...
Breaking Medicine Technology:
Cached News: