HOME >> MEDICINE >> NEWS
New details on how the immune system recognizes influenza

Drawing upon a massive database established with funds from the National Institute of Allergy and Infectious Diseases (NIAID), one of the National Institutes of Health (NIH), scientists have completed the most comprehensive analysis to date of published influenza A virus epitopes--the critical sites on the virus that are recognized by the immune system. The findings, reported by researchers at the La Jolla Institute for Allergy and Immunology (LIAI), are being published online this week by the journal Proceedings of the National Academy of Sciences.

The study should help scientists who are designing new vaccines, diagnostics and immune-based therapies against seasonal and pandemic influenza because it reveals in molecular detail exactly where the immune system focuses on the viruses. Although the complete molecular structures of essentially all major strains of influenza viruses are known, immune responses concentrate on limited regions of certain parts of the virus, and these regions must be identified as immune epitopes by research studies. The LIAI team found that while there were hundreds of shared epitopes among different virus strains, including the avian H5N1 virus, only one has been published that appears ideal for multi-strain vaccines. Information on shared protective epitopes is important for developing influenza vaccines that can provide broad protection against multiple strains of the virus.

"This study is interesting for what it shows we know and do not know," says NIAID Director Anthony S. Fauci, M.D. "It reveals many gaps in our knowledge of influenza viruses and indicates where we need to focus our attention."

The analysis drew upon a much larger effort called the Immune Epitope Database and Analysis Resources Program, which began in 2004 after NIAID awarded LIAI a $25 million contract to create a single repository of immune epitopes from critical disease-causing microbes, including agents that might be used in a bioter
'"/>

Contact: Jason Socrates Bardi
jbardi@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
1-Jan-2007


Page: 1 2 3 4

Related medicine news :

1. Study details catastrophic impact of nuclear attack on US cities
2. New details in schizophrenia treatment trial emerge
3. Study details why listeriosis rates are 20-fold higher during pregnancy
4. Working memory retains visual details despite distractions
5. Report describes details of four transplant recipients who contracted rabies from donor
6. Penn study finds pro-death proteins required to regulate healthy immune function
7. Scientists develop method to track immune system enzyme in live animals
8. Thymus transplants gives hope to babies with fatal immune disease
9. Vitamin D supplements may offer cheap and effective immune system boost against TB
10. Stanford researchers identify immune dysfunction in melanoma patients
11. Head and neck cancer vaccine targets proteins to create immune response

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2020)... ... May 28, 2020 , ... ... in the fall, operators of student housing are scrambling to implement practices that ... manages over 37,000 student housing beds on 38 campuses across the country, has ...
(Date:5/27/2020)... ... May 27, 2020 , ... Radiology Associates ... the United States, has aligned with the Strategic Radiology (SR) coalition of independent ... to join the SR coalition, which has 28 member practices in 20 different ...
(Date:5/26/2020)... LIVONIA, Mich. (PRWEB) , ... ... ... and RevSpring today announced the availability of two leading RevSpring solutions—Talksoft® patient ... Loyale Patient Payment platform by engaging patients through automated and precise texts, ...
(Date:5/26/2020)... NEW YORK (PRWEB) , ... May 26, 2020 ... ... due to the coronavirus pandemic, medical centers across the United States are joining ... front-line health care workers who have worked tirelessly to save lives. #FitForTheFrontLine is ...
(Date:5/21/2020)... CITY, Mich. (PRWEB) , ... May 21, 2020 , ... ... a hands-free door opener that allows users to open swing-style doors without using ... doors and allows people to pull the door open using their forearm, wrist or ...
Breaking Medicine News(10 mins):
(Date:5/30/2020)... ... 2020 , ... HealthyChildren.org, the official parenting website of the American Academy of ... Fourteen lucky winners will receive a $200 Amazon.com* gift card. The contest begins June ... each day during the event. Winners will be drawn on or about June 22, ...
(Date:5/30/2020)... , ... May 30, 2020 , ... ... dealing with a host of new issues related to COVID-19. Recently, Wellness Expert ... to help expectant moms support their pregnancy and postpartum. , A video ...
(Date:5/28/2020)... ... May 28, 2020 , ... Escalating healthcare costs ... Technologies, leader and innovator in essential vision testing products, to launch web-based vision ... Vision Testing has been released and considering the circumstances, could not be more ...
Breaking Medicine Technology:
Cached News: