HOME >> MEDICINE >> NEWS
New drug candidate against HIV developed in Sweden

As a part of a research collaboration, scientists at the Sahlgrenska Academy at Gteborg University, Sweden, have developed a new drug candidate against HIV-infection. The new substance, named alphaHGA, will be tested on patients this year. In a thesis from the Sahlgrenska Academy, parts of the research essential for the performance of the clinical trial are presented.

At the end of 2004, approximately 40 million people were living with HIV-infection, most of them in southern Africa. Annually, approximately three million people die from the infection, many of them young. Despite huge efforts, there has been no success in developing a vaccine against HIV. However, a number of drugs are used for treatment of HIV-infected individuals. The drugs cannot cure an infected person, but can slow down the disease progression. There are about 20 drugs commercially available, but since the virus can develop resistance and since the drugs are associated with side effects, there is a need for new, safer drugs.

Elin Andersson, M.Sc, presents in her thesis studies showing that the compound GPG-NH2 inhibits HIV in culture.

"GPG-NH2 inhibited the virus by a new mechanism of action. The molecule prevented the virus from forming the correct structure, and was therefore active against HIV resistant to currently available drugs" says Elin Andersson.

She also showed that in culture, HIV developed resistance to drugs used on patients today, but not to GPG-NH2. GPG-NH2 was tested on HIV-infected patients in 2001. The effect on HIV showed in culture could however not be reproduced in patients. Elin Andersson and the other scientists have now shown that GPG-NH2 in itself did not inhibit the virus. Instead, it needed to be degraded and one of the products from degradation, a so-called metabolite, was the actual active compound. The metabolite was produced by enzymatic degradation in the viral cultures. This degradation of GPG-NH2 to the active metabolite, nam
'"/>

Contact: Ulrika Lundin
ulrika.lundin@sahlgrenska.gu.se
46-31-773-38-69
Swedish Research Council
29-Jun-2005


Page: 1 2

Related medicine news :

1. Novel candidate biomarker for heart failure also strongly predicts risk of death
2. Indias DBT and IAVI forge partnership to develop next generation vaccine candidates
3. New international guidelines for heart transplant candidates standardize patient care
4. Major biomarker candidates for Alzheimers disease explored
5. Test identifies best candidates for implanted cardiac defibrillator, screens out those not helped
6. Decline in performance of candidates taking a postgraduate medical examination between 1997 and 2001
7. A promising candidate for a Lassa fever vaccine
8. A candidate biomarker to improve treatment of lupus patients
9. Higher education representatives advise chemistry faculty candidates on how to apply for positions
10. Antioxidants show no clear benefit against cardiovascular events, death in high-risk women
11. DNA vaccine against multiple sclerosis appears safe, potentially beneficial

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... ... that offers insurance and financial preparation services, is providing an update on a ... organization. , Rock City Rescue is a locally recognized nonprofit that provides shelter ...
(Date:10/13/2017)... ... 13, 2017 , ... PurhealthRX , a leading Health and Nutrition Company, ... Purzorb™process to full spectrum CBD oil will revolutionize the rapidly growing CBD market by ... be easily incorporated into liquid products, while reducing costs to end users. , The ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... The Visiting ... Day Market. Featuring a collection of specialty vendors and unique items from across the ... and quality-focused health and wellness services offered by the VNA. The boutique will ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in ... awarded a contract by the Center for Medicare and Medicaid Services (CMS). The ... enterprise use of Agile methodologies in a consistent and high value manner across ...
(Date:10/12/2017)... , ... October 12, 2017 , ... Planet Fitness, one ... U.S., announced today its plans to open a flagship location in Covington, LA at ... former Rooms To Go store next to Office Depot in the Holiday Square shopping ...
Breaking Medicine News(10 mins):
(Date:9/23/2017)... -- Janssen Biotech, Inc. (Janssen) announced today that it ... Food and Drug Administration (FDA) for the Biologics License ... of moderately to severely active rheumatoid arthritis (RA). The ... to further evaluate the safety of sirukumab in the ... "We are disappointed by ...
(Date:9/19/2017)... Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing a non-invasive, ... tissues, announced three leadership team developments today:   ... ... ... Veteran medical device executive Josh Stopek , PhD, ...
(Date:9/18/2017)... , Sept. 18, 2017 EpiVax, ... of bioinformatics and immune engineering, today announced ... influenza A (H7N9) vaccine. ... to seasonal influenza and presents a challenge ... prior exposure to be effective. Using state-of-the-art ...
Breaking Medicine Technology:
Cached News: