HOME >> MEDICINE >> NEWS
New drug shows promise in treatment of advanced thyroid cancer

The investigational drug axitinib produced tumor regression or stable disease in almost three-out-of-four patients with advanced thyroid cancer, a research team reported at the annual meeting of the American Society for Clinical Oncology in Chicago.

In this exploratory phase-2 trial, 18 out of 60 patients (30%) had their tumors shrink by 31 to 83 percent. Another 25 patients (42%) had stable disease, with no tumor progression or slight reduction in size, when measured at four months. Many of those patients still have stable disease.

"This is exciting," said study presenter Ezra Cohen, MD, PhD, assistant professor of medicine at the University of Chicago. "Until now we really didn't have anything to offer thyroid cancer patients with advanced disease that was refractory to standard measures."

Although this drug did not produce complete responses, it appears to have caused "significant tumor reduction in most subjects," he added, "Axitinib has prevented the disease from progressing in most patients, and in a lasting way."

In this trial, which began nearly three years ago, "the median duration of stable disease has not been reached," Cohen said. "Twenty-four patients are still in treatment."

Axitinib is a small molecule designed to prevent tumors from acquiring the blood supply they need to grow. It blocks all three known receptors for a substance called vascular endothelial growth factor (VEGF), a biologic factor tumors release in order to grow new blood vessels in the tumor, a process called angiogenesis.

The study confirmed that the drug worked as predicted. Treatment significantly reduced the presence of soluble VEGF receptors, VEGFR2 and VEGFR3, in blood. Levels of VEGF in the blood increased, suggesting that this growth factor was compensating for angiogenesis inhibition by axitinib.

More importantly, it prevented tumor growth. In only 10 out of 60 patients (17%) did the tumors con
'"/>

Contact: John Easton
john.easton@uchospitals.edu
773-702-6241
University of Chicago Medical Center
4-Jun-2007


Page: 1 2

Related medicine news :

1. New study shows promise in reducing surgical risks associated with surgical bleeding
2. Most seniors now have drug coverage, U-M study shows
3. Wireless technology shows promise in diagnosing pediatric intestinal disease
4. Study shows radiofrequency ablation highly effective in treating kidney tumors
5. Method shows promise for early detection of pancreatic cancer
6. Organic farming can feed the world, U-M study shows
7. New study shows Rescue Remedy is an effective all-natural stress, anxiety reliever
8. Borderline personality disorder shows improvements with intensive psychotherapy
9. Study shows Diachrome improves blood sugar control in people with type 2 diabetes
10. Trial shows circulating tumor cells predict how prostate cancer patients do with chemotherapy
11. Research shows survival benefit for leukemia patients treated with arsenic trioxide

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2019)... ... August 21, 2019 , ... ISOComforter , a leader in providing products for cold ... system starts with a powered cold unit supply that is shaped like a ... with the unit, such as the shoulder pad, lumbar pad, hip wrap, or knee pad. ...
(Date:8/21/2019)... ... August 21, 2019 , ... Future residents got their ... Phase II expansion of Providence Point in Pittsburgh’s Scott Township neighborhood involved additions, ... the 70-unit apartment tower, Hamilton Tower. , The expansion began two ...
(Date:8/19/2019)... (PRWEB) , ... August 19, 2019 , ... ... platform selling Eminence Organic Skin Care products , the authorized retailer will ... Darlene DeVries, was a practicing esthetician in Florida providing Eminence Organic Skin Care ...
(Date:8/19/2019)... ... 2019 , ... ProRehab Louisville and Dr. Stacie Grossfeld have partnered with Louisville ... to top-notch sports medical care and sport injury experts for rehabilitation. , “It ... skating, knows the individualized treatment plan, and understands what a triple toe loop is ...
(Date:8/19/2019)... ... August 19, 2019 , ... A July 26 article ... be brushing their pets’ teeth twice a day. The acknowledges that, with dogs not ... suggests that close monitoring and brushing at least twice a week is likely enough ...
Breaking Medicine News(10 mins):
(Date:8/16/2019)... ... , ... SignatureCare Emergency Center has announced that it is ... Heights, Memorial City, and Bellaire, TX. , The one-day health fair on Tuesday, ... helping Houston families get their children caught up on wellness checks, immunizations and ...
(Date:8/16/2019)... Fla. (PRWEB) , ... August 16, 2019 , ... ... Technology (IT) Innovator, Tricia Lee (Wilkins) Rolle, PharmD, PhD, has joined the company ... will work with public and private sectors and industry standards organizations to advance ...
(Date:8/15/2019)... ... 15, 2019 , ... On Sunday, August 4th, volunteers from Bright Now!® ... difference in the South LA community. Six doctors joined with their dedicated support staff ... , and more at the South Gate Day of Giving. , Over 50 ...
Breaking Medicine Technology:
Cached News: