New drugs improve bone marrow cancer outlook

Decitabine, a new drug undergoing Phase III efficacy trials, provides palliative therapy for patients with the bone marrow disease called Myelodysplastic Syndrome (MDS), according to a new study. Published in the April 15, 2006 issue of CANCER (http://www.interscience.wiley.com/cancer-newsroom), a peer-reviewed journal of the American Cancer Society, the study indicates that decitabine provided longer disease-free responses compared to supportive care. While the development of decitabine and other chemotherapies is making an impact on the lives of patients with MDS, an accompanying editorial argues that these current treatments are palliative at best and will have little additional improvement in survival.

MDS is a bone marrow disease of the elderly and one of the common geriatric blood-related cancers. It causes an increasing number of dysfunctional blood cells called blasts to proliferate in the blood at the expense of normal, functional cells i.e., red blood cells to carry oxygen; white blood cells to fight infections; and platelets to control bleeding. MDS can be a chronic progressive disease with median survival over 5 years or a rapidly progressive disease complicated by acute myeloid leukemia (AML) with survival less than 5 years.

However, because most MDS patients are elderly and have too many risk factors to undergo a bone marrow transplant, therapy is often supportive. Chemotherapy regimens used for leukemia have been used, but results are disappointing and suggest great risk to patient lives than benefit. New drugs, such as 5--azacytidine, lenalidomide, decitabine, and cytarabine, are now being tested for efficacy and safety to treat MDS. Compared to supportive care, they generally have some quality of life and survival benefits.

In the new decitabine trial published in the April 15, 2006 issue of CANCER, researchers led by Hagop Kantarjian, M.D. of the University of

Contact: David Greenberg
John Wiley & Sons, Inc.

Page: 1 2

Related medicine news :

1. UIC researchers to develop new drugs to fight bioterrorism
2. Statin drugs may delay progressive artery damage in children
3. Study finds HIV protease inhibitor drugs may adversely affect the scaffolding of the cell nucleus
4. Experts call for urgent research into anti-epileptic drugs given to children
5. UCLA researchers develop new nanomaterials to deliver anti-cancer drugs to cells
6. Antipsychotic drugs increase risk of death in older people with dementia
7. Antipsychotic drugs increase risk of death in older people with dementia
8. Gene variations point to why lung cancer drugs work better in Japanese vs. US patients
9. Panel offers guidelines on skin reactions to new class of cancer drugs
10. Blood-thinning drugs need closer monitoring
11. Comparison of patients access to new and better cancer drugs reveals inequalities between countries

Post Your Comments:

(Date:12/9/2019)... ... December 09, 2019 , ... ... solutions that help food and manufacturing companies engage with their workforces to ... turnkey solution helps manufacturers build a cohesive culture that is designed to ...
(Date:12/8/2019)... , ... December 07, 2019 , ... More than 85 ... a recent report from the American Academy of Dermatology, indicating this problem is more ... upward trend during the years to come. These dermatological conditions vary in type and ...
(Date:12/8/2019)... SEATTLE (PRWEB) , ... December 08, 2019 , ... ... higher education planning, has announced the Top 52 Best Homeland Security Degree Programs ... accredited colleges and universities in the nation. Each program is evaluated based on ...
(Date:12/6/2019)... ... 2019 , ... Connecticut is home to a growing healthcare ... On December 12th, Hartford Business Journal will recognize eight individuals and organizations who ... the Hartford Marriott. , “We are fortunate to have so many great providers ...
(Date:12/6/2019)... , ... December 06, 2019 , ... Lasair Aesthetic Health Sponsors Toys for Tots to ... of Botox to Patients Who Bring in Toys During the Holidays , Lasair Aesthetic Health ... now until Christmas, patients who bring in a toy or toys worth more than 25-dollars, ...
Breaking Medicine News(10 mins):
(Date:12/5/2019)... ... December 05, 2019 , ... Intelligent.com, a ... Top 27 Respiratory Therapy Degree Programs for 2020. The comprehensive research guide is ... Each program is evaluated based on curriculum quality, graduation rate, reputation, and post-graduate ...
(Date:12/5/2019)... ... December 05, 2019 , ... nView, a leading behavioral health ... role of Chief Product Officer. As the company expands its portfolio of software ... behavioral health market into nView’s product and company growth strategy. Rosenbaum will report ...
(Date:12/4/2019)... LAKE FOREST, Calif. (PRWEB) , ... December 04, ... ... medical technology company providing healthcare professionals with minimally invasive technologies to treat chronic ... 100,000 procedures performed with the Tenex Health TX® technology. , Dr. ...
Breaking Medicine Technology:
Cached News: