HOME >> MEDICINE >> NEWS
New family of biodegradable polymers shows promise for intracellular drug delivery

A newly developed family of biodegradable polymers has shown potential for use in intracellular delivery and sustained release of therapeutic drugs to the acidic environments of tumors, inflammatory tissues and intracellular vesicles that hold foreign matter.

These polymers have several advantages over existing biodegradable polymers, researchers said. Among them, the polymers called polyketals are biodegradable into Food and Drug Administration-approved compounds, such as food additives. Synthesis is a simple and easily customized process. Degradation of the polymer does not produce inflammation-causing acid, but instead generates membrane-permeable products that allow all of the polymer's byproducts to diffuse outside the cell. That means byproducts shouldn't accumulate in a patient's tissue and cause inflammation.

"We've known for 20 to 30 years that when cells take up particles, they move them to a part of the cell with a low pH -- about 5.0," said Niren Murthy, an assistant professor in the Wallace H. Coulter Department of Biomedical Engineering at the Georgia Institute of Technology and Emory University. "Researchers have been able to successfully exploit this process in cell culture and in animal models, but have done so using materials that generated acid degradation products and that hydrolyzed too slowly for chronic use. Thus, there has been very little clinical activity in this area."

However, polyketal nanoparticles use the cell's acid to hydrolyze into hydrophilic compounds that can release encapsulated therapeutics at an accelerated rate in the acidic environments to which they are targeted, Murthy explained. Also, unlike polyester-based biomaterials, polyketal nanoparticles do not generate acid when they degrade. Researchers don't know yet whether polyketals will be less inflammatory than current polymers used for drug delivery, but expect to evaluate this response within the next year.

Murthy will present information on the d
'"/>

Contact: Jane Sanders
jane.sanders@edi.gatech.edu
404-894-2214
Georgia Institute of Technology Research News
27-Mar-2006


Page: 1 2 3

Related medicine news :

1. Extended family ties influenced evacuation decisions during Hurricane Katrina
2. Chronic family turmoil and other problems cause physical changes
3. Computer predicts wishes of incapacitated patients better than family or loved ones
4. New family health history projects focus on Alaska Native, Appalachian communities
5. Peer and family support tops needs of young adult cancer survivors
6. Study calls for 39 percent more family physicians
7. Work-family conflict common among registered nurses, study shows
8. Most doctors not adequately trained in family planning options
9. Research documents childrens exposure to pesticides, suggests need for family education
10. New lifestyles, new data planners need a modern definition of the family
11. Few gay man regret disclosing HIV status to friends, family

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/20/2019)... ... March 20, 2019 , ... Capio®, the leading provider of ... to 2018. In total, sales generated for 2018 were the highest ever for ... significant accomplishments and milestones in 2018. In addition to achieving record sales and ...
(Date:3/20/2019)... ... March 20, 2019 , ... VirtuOx, ... a new way to diagnose cardiac arrhythmias in the patient’s home. , The ... by utilizing mobile cardiac telemetry (MCT) in the convenience and comfort of the ...
(Date:3/20/2019)... ... March 20, 2019 , ... cbdMD, a Level ... – Mingo Rad. , Mingo Rad dedicates its resources to offering superior ... with a unique manufacturing process, Mingo Rad offers as non-GMO, gluten- and THC-free ...
(Date:3/20/2019)... ... 20, 2019 , ... Adam Equipment, a leading provider of professional balances worldwide, ... from 26-28 March at Paris expo Porte de Versailles in France. , During the ... series of balances. Both balance lines include models that deliver two to five places ...
(Date:3/19/2019)... Pa. (PRWEB) , ... March 19, 2019 , ... The ... team with the hiring of industry expert William Mencia, M.D., FACEHP, CHCP. Dr. ... Prova Education , Omnia Education , Medtelligence , and AGILE ...
Breaking Medicine News(10 mins):
(Date:3/20/2019)... (PRWEB) , ... March 20, ... ... digital marketplace for outsourced research services and products, announced today that it ... of HEOR services. The Canadian-based company offers RWE research, systematic literature review, ...
(Date:3/20/2019)... ... March 20, 2019 , ... NDA Partners Chairman ... with extensive experience in the development of generic drugs and drug/device combination products at ... as an Expert Consultant. , During his career with FDA, Mr. Gonitzke served as ...
(Date:3/19/2019)... , ... March 19, 2019 , ... TreTap Launches First-Ever ... during two week online contest – One winner will receive TreTap beverages for a ... first ever CBD infused maple water beverage. Tretap, which was acquired by Vermont’s original ...
Breaking Medicine Technology:
Cached News: