HOME >> MEDICINE >> NEWS
New family of biodegradable polymers shows promise for intracellular drug delivery

A newly developed family of biodegradable polymers has shown potential for use in intracellular delivery and sustained release of therapeutic drugs to the acidic environments of tumors, inflammatory tissues and intracellular vesicles that hold foreign matter.

These polymers have several advantages over existing biodegradable polymers, researchers said. Among them, the polymers called polyketals are biodegradable into Food and Drug Administration-approved compounds, such as food additives. Synthesis is a simple and easily customized process. Degradation of the polymer does not produce inflammation-causing acid, but instead generates membrane-permeable products that allow all of the polymer's byproducts to diffuse outside the cell. That means byproducts shouldn't accumulate in a patient's tissue and cause inflammation.

"We've known for 20 to 30 years that when cells take up particles, they move them to a part of the cell with a low pH -- about 5.0," said Niren Murthy, an assistant professor in the Wallace H. Coulter Department of Biomedical Engineering at the Georgia Institute of Technology and Emory University. "Researchers have been able to successfully exploit this process in cell culture and in animal models, but have done so using materials that generated acid degradation products and that hydrolyzed too slowly for chronic use. Thus, there has been very little clinical activity in this area."

However, polyketal nanoparticles use the cell's acid to hydrolyze into hydrophilic compounds that can release encapsulated therapeutics at an accelerated rate in the acidic environments to which they are targeted, Murthy explained. Also, unlike polyester-based biomaterials, polyketal nanoparticles do not generate acid when they degrade. Researchers don't know yet whether polyketals will be less inflammatory than current polymers used for drug delivery, but expect to evaluate this response within the next year.

Murthy will present information on the d
'"/>

Contact: Jane Sanders
jane.sanders@edi.gatech.edu
404-894-2214
Georgia Institute of Technology Research News
27-Mar-2006


Page: 1 2 3

Related medicine news :

1. Extended family ties influenced evacuation decisions during Hurricane Katrina
2. Chronic family turmoil and other problems cause physical changes
3. Computer predicts wishes of incapacitated patients better than family or loved ones
4. New family health history projects focus on Alaska Native, Appalachian communities
5. Peer and family support tops needs of young adult cancer survivors
6. Study calls for 39 percent more family physicians
7. Work-family conflict common among registered nurses, study shows
8. Most doctors not adequately trained in family planning options
9. Research documents childrens exposure to pesticides, suggests need for family education
10. New lifestyles, new data planners need a modern definition of the family
11. Few gay man regret disclosing HIV status to friends, family

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/15/2018)... YORK (PRWEB) , ... September 14, 2018 , ... ... of “Rare Diseases." This campaign will showcase the innovative work being done within ... as potential future therapies for those living with rare diseases. ...
(Date:9/13/2018)... ... 2018 , ... The Kelly Foundation awarded $83,000 to Saint ... women and children experiencing homelessness in the Sacramento region. The donation will go towards ... doors of Saint John’s open after the County of Sacramento decided not to renew ...
(Date:9/12/2018)... ... September 12, 2018 , ... Today, Sterling , a ... Beck, attempted the first unassisted adaptive climb of the Lotus Flower Tower in Canada’s ... it difficult for him to lead, the duo decided to persevere and with some ...
(Date:9/12/2018)... ... , ... Glori Blends will be attending the CBD Expo West 2018 in ... vendors, presentations, panel discussions and a special pavilion for pet line products. The creators ... and assist customers with the best selection for their individual needs. , The address ...
(Date:9/7/2018)... ... September 07, 2018 , ... ... , the only OSHA authorized OTI Education Center headquartered in Northern California, is ... who feel they have experienced retaliation in response to engaging in activity protected ...
Breaking Medicine News(10 mins):
(Date:9/12/2018)... ... ... Donaldson Plastic Surgery has been included on the Inc. 5000 list of ... of central Ohio's fastest growing businesses. The plastic surgery practice was ranked number 4,202 ... the only medical practice and plastic surgery office to make the regional Fast 50 ...
(Date:9/7/2018)... (PRWEB) , ... September 07, 2018 , ... ... completed her new book “Diagnosis: Cancer”: a gripping narrative that shows the author’s ... and in Africa. , Author Uonelli writes an eventful life that revolves around ...
(Date:9/3/2018)... , ... September 03, 2018 , ... ... number of residents with more than 1,200 residents and 200 fellows for the ... Carolina twenty-third-largest in the nation. Charleston area institutions such as McLeod Health, MUSC ...
Breaking Medicine Technology:
Cached News: