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New imaging compound might 'see' Alzheimer's earlier

Two years later, follow-up testing on a subset of the volunteers showed that FDDNP PET scans continued to correlate well with their clinical symptoms and diagnoses.

"The hope is that better imaging techniques and markers will allow us to conduct clinical trials with fewer volunteers and in less time," says Susan Molchan, M.D., program officer in the NIA Neuroscience and Neuropsychology of Aging Program. "The ability to image brain changes may allow us to see how drugs affect the accumulation of proteins in the brain that cause Alzheimer's plaques and tangles, possibly preventing or delaying the progression of Alzheimer's."

In a separate but related project, NIA also leads the Alzheimer's Disease Neuroimaging Initiative (ADNI), a federal government and private sector partnership that seeks to discover imaging techniques and other biomarkers that, over time, can measure biological changes in the progression from mild cognitive impairment to Alzheimer's disease. One component of the initiative will compare PET scans using another compound that binds to Alzheimer's disease plaques, Pittsburgh Compound B, with other tests.


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Contact: Linda Joy
nianews3@mail.nih.gov
301-496-1752
NIH/National Institute on Aging
20-Dec-2006


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