HOME >> MEDICINE >> NEWS
New immune cell found to be a key to inflammatory diseases

functions, and how it can go awry, is important, Dong says.

T cells are white blood cells that play a variety of roles in the immune system, including the identification of foreign molecules in the body, such as bacteria and viruses, and the activation and deactivation of other immune cells.

T helper cells are specific T cells that have receptors that recognize and bind to fragments (known as antigens) of the invaders that already have been displayed on the surface of other immune system cells. (These T helper cells are also called CD4 T cells since they express CD4 molecules.) Once the antigen has been bound, these T helper cells become activated, and they morph into "effector" cells which then boost an immune response by secreting "cytokine" molecules such as interleukins and interferons.

Before this study, two such different types of effector T helper cells had been known - type I (TH1), linked to the body's response to microbial infection, and type 2 (TH2), which plays a crucial function in production of B cell antibodies and also is associated with development of allergies.

Although TH1 and TH2 are known to produce powerful cytokines - such as interferon-gamma (IFN-g) and allergy-associated interleukin 4 (IL-4), respectively - they are not inflammatory or associated with production of IL-17, which sets off an errant immune response that results in tissue inflammation.

Researchers could not understand the origins of such an inflammatory response in body tissues. The only clue they had was that excess IL-17 molecules are found in arthritic joints, in lungs swollen by asthma and in brain cells that lead to nerve degeneration and the onset of MS. "But we didn't know which T cells were responsible for secreting IL-17," Dong says. To find out where IL-17 came from, the researchers designed a series of cell culture studies and mouse experiments. In brief, they "educated" T helper cells to become IL-17 producing cells. They fo
'"/>

Contact: Nancy Jensen
nwjensen@mdanderson.org
713-794-1584
University of Texas M. D. Anderson Cancer Center
2-Oct-2005


Page: 1 2 3

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. Scientists develop method to track immune system enzyme in live animals
3. Thymus transplants gives hope to babies with fatal immune disease
4. Vitamin D supplements may offer cheap and effective immune system boost against TB
5. Stanford researchers identify immune dysfunction in melanoma patients
6. Head and neck cancer vaccine targets proteins to create immune response
7. Weak immune response critical to disease that causes most infant hospitalizations
8. Blocking immune cell action increases Alzheimers-associated protein deposits
9. Insight on fruit fly immune system could lead to new types of vaccines, Stanford researchers say
10. Why doesnt the immune system attack the small intestine?
11. New details on how the immune system recognizes influenza

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/4/2020)... ... June 04, 2020 , ... The experience of making or watching a ... on art. Then came the COVID-19 pandemic and physical distancing. “The German film industry ... International Film Festival (BIFF). That is, “all stages of the film business, exhibition, production, ...
(Date:5/30/2020)... ... ... Worldwide Business with kathy ireland® will be LIVE streaming this week’s ... 2020 at 8:00pm ET / PT – two chances to watch each night! This episode’s ... Diagnostic Solutions Laboratory . , As leaders in their industries, these ...
(Date:5/28/2020)... ... May 28, 2020 , ... ... new 7th Donor Shield protection. Donors can now be reimbursed for lost wages ... program. The other six Donor Shield protections include lost wage reimbursement for donation, ...
(Date:5/27/2020)... ... May 27, 2020 , ... ... Dr. Gerald Pollack, University of Washington Professor of Bioengineering, Founder & Editor ... Solid, Liquid & Vapor ( https://www.amazon.com/Fourth-Phase-Water-Beyond-Liquid-ebook/dp/B00N2ASKF2 ) , https://www.voiceamerica.com/episode/123059/the-fourth-phase-of-water ...
(Date:5/26/2020)... ... 26, 2020 , ... As much of the country continues ... are joining forces to start a country-wide movement of physical activity to honor ... #FitForTheFrontLine is a national fitness challenge beginning Tuesday, May 26 and culminating on ...
Breaking Medicine News(10 mins):
(Date:6/4/2020)... ... June 04, 2020 , ... One minute it was business as ... entered the lexicon. COVID-19 turned the world on its head, and everything ground to ... The AutismOne annual conference went from a physical event to a virtual one in ...
(Date:6/3/2020)... (PRWEB) , ... June 03, 2020 , ... The Conference ... in Clinical Trials conference to take place on September 21st, 2020. This annual conference ... to reduce the barriers for patients and physicians to participate in clinical research. , ...
(Date:6/3/2020)... (PRWEB) , ... June 03, 2020 , ... ... people over 75, announced today the addition of connected device capabilities to its ... healthcare providers. The expanded capabilities come at a time when an increasing number ...
Breaking Medicine Technology:
Cached News: