HOME >> MEDICINE >> NEWS
New insight into cause of Crohn's disease

UK scientists have found evidence that suggests Crohn's disease is caused by a weak immune response. The researchers, who report their findings in an Article in this week's issue of The Lancet, also suggest that sildenafil (Viagra) might help in the treatment of the disease.

Crohn's disease is a chronic inflammatory disorder that causes ulcerations in the small and large intestines. Many scientists consider Crohn's to be an autoimmune disease--an illness that occurs when the body tissues are attacked by its own immune system. However, Anthony Segal (University College London, UK) and colleagues have found that, counter intuitively, the inflammation in Crohn's arises due to a weak immune response.

The investigators looked at the quantities of neutrophils (white blood cells) that patients with Crohn's disease produce in response to trauma at sites in the bowel (intestinal biopsy) and on the skin surface (skin abrasion). They found that in response to trauma, Crohn's disease patients produced much lower quantities of neutrophils and inflammatory mediators when compared with healthy individuals. Cultured blood cells were also abnormal in the patients. To test the inflammatory response to bacteria, the team also measured local inflammatory and blood flow changes in participants after injecting a harmless form of Escherichia Coli under their skin. In the healthy controls, blood flow in the area of inflammation increased approximately ten-fold by 24 hours. Crohn's disease patients, however, had much lower blood flow than controls. The researchers found that the abnormally low blood flow in Crohn's patients could be corrected by treatment with Viagra, indicating a possible role for the drug in the treatment of the disease.

The authors believe that in Crohn's disease, reduced or delayed recruitment of neutrophils to sites at which bacteria penetrate the intestinal wall might lead to the persistence of bacteria and other organic debris in the tissue.
'"/>

Contact: Joe Santangelo
j.santangelo@elsevier.com
212-633-3810
Lancet
23-Feb-2006


Page: 1 2

Related medicine news :

1. Sports concussion research using fMRI provides insight for safe return-to-play decisions
2. Better insight into brain anatomical structures
3. New insights into chronic inflammation and atherosclerosis
4. New insights into autoimmunity and depression
5. NIAID media availability: Examining genetic variability of malaria parasite offers insight
6. Functional brain imaging insights from UC San Diego grad student
7. More insight into Alzheimers disease with Stanford discovery of possible cause
8. Sticky proteins provide new insight into drug action
9. Laser probe of a brain pigments anatomy may offer insight into Parkinsons disease
10. New insights into the impact of pregnancy on inflammatory arthritis
11. Amnesiac study offers insights into how working memory works

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/22/2017)... CA (PRWEB) , ... August 22, 2017 , ... ... accessible luxurious collection of unique masks and serums that perfectly fuse the beauty ... care advancements, at the 2017 Indie Beauty Expo on August 23rd & 24th ...
(Date:8/22/2017)... Davis, California (PRWEB) , ... August 22, 2017 ... ... implies that the key to good health is as simple as eating healthy ... to food—whether it be storing fat, making insulin, or breaking apart carbohydrates—depends not ...
(Date:8/22/2017)... , ... August 22, 2017 , ... ... pleased to announce the addition of Zack Tisch as the firm’s new Consulting ... KLAS-ranked healthcare IT consulting firm’s national accounts, from assisting clients with initial vendor ...
(Date:8/22/2017)... ... August 22, 2017 , ... GeBBS Healthcare ... the availability of a new professional fee E/M leveling calculator tool. The new ... the healthcare industry. E/M coding is complex which supports the need for a ...
(Date:8/22/2017)... ... ... Star Glass is new to the Texas market, but is proudly managed by widely recognized ... and models, in Grand Prairie, TX, located in the center of the DFW Metroplex, the ... business for the past 40 years with 32 convenient locations in Texas, Nevada and California ...
Breaking Medicine News(10 mins):
(Date:8/18/2017)... 18, 2017  Nortis today announced the awarding of a $688K National Institutes ... third year of a Small Business Innovation Research (SBIR)?Fast-track grant ... Neurological Disorders and Stroke (NINDS).?  ... Nortis ParVivo Chip used for ... ...
(Date:8/17/2017)... EWING, N.J. , Aug. 17, 2017 Bio-Ess Laboratories, LLC ... to increase antibody titer and present new data on Cell-Ess® ... in Boston, MA August 21-25.  The Bioprocessing ... for today,s bioprocess challenges. ... Boost and Optimizer ...
(Date:8/15/2017)... 15, 2017  Axium Pharmaceuticals Inc., the creator of the drug ... the beginning stages of an IPO. The United ... the average cost of a prescription epilepsy drug being $450.00-$1200.00 for a ... AXIUM PHARMACEUTICALS, INC ... Another staggering figure is the fact that Americans spent $42 ...
Breaking Medicine Technology:
Cached News: