HOME >> MEDICINE >> NEWS
New insight into cause of Crohn's disease

UK scientists have found evidence that suggests Crohn's disease is caused by a weak immune response. The researchers, who report their findings in an Article in this week's issue of The Lancet, also suggest that sildenafil (Viagra) might help in the treatment of the disease.

Crohn's disease is a chronic inflammatory disorder that causes ulcerations in the small and large intestines. Many scientists consider Crohn's to be an autoimmune disease--an illness that occurs when the body tissues are attacked by its own immune system. However, Anthony Segal (University College London, UK) and colleagues have found that, counter intuitively, the inflammation in Crohn's arises due to a weak immune response.

The investigators looked at the quantities of neutrophils (white blood cells) that patients with Crohn's disease produce in response to trauma at sites in the bowel (intestinal biopsy) and on the skin surface (skin abrasion). They found that in response to trauma, Crohn's disease patients produced much lower quantities of neutrophils and inflammatory mediators when compared with healthy individuals. Cultured blood cells were also abnormal in the patients. To test the inflammatory response to bacteria, the team also measured local inflammatory and blood flow changes in participants after injecting a harmless form of Escherichia Coli under their skin. In the healthy controls, blood flow in the area of inflammation increased approximately ten-fold by 24 hours. Crohn's disease patients, however, had much lower blood flow than controls. The researchers found that the abnormally low blood flow in Crohn's patients could be corrected by treatment with Viagra, indicating a possible role for the drug in the treatment of the disease.

The authors believe that in Crohn's disease, reduced or delayed recruitment of neutrophils to sites at which bacteria penetrate the intestinal wall might lead to the persistence of bacteria and other organic debris in the tissue.
'"/>

Contact: Joe Santangelo
j.santangelo@elsevier.com
212-633-3810
Lancet
23-Feb-2006


Page: 1 2

Related medicine news :

1. Sports concussion research using fMRI provides insight for safe return-to-play decisions
2. Better insight into brain anatomical structures
3. New insights into chronic inflammation and atherosclerosis
4. New insights into autoimmunity and depression
5. NIAID media availability: Examining genetic variability of malaria parasite offers insight
6. Functional brain imaging insights from UC San Diego grad student
7. More insight into Alzheimers disease with Stanford discovery of possible cause
8. Sticky proteins provide new insight into drug action
9. Laser probe of a brain pigments anatomy may offer insight into Parkinsons disease
10. New insights into the impact of pregnancy on inflammatory arthritis
11. Amnesiac study offers insights into how working memory works

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/6/2016)... ... 06, 2016 , ... 'Tis the season for family, festivity, food and fun! ... the season when eating healthy, staying active, and taking medication and doing daily foot ... do. , "Shopping trips, parties and family gatherings can take their toll on ...
(Date:12/6/2016)... , ... December 06, 2016 , ... ... , the only authorized OSHA Training Institute Education Center headquartered in Northern California, ... program focused on providing occupational safety and health training to public sector employees. ...
(Date:12/5/2016)... ... December 05, 2016 , ... Edward Buckingham MD ... the arrival of the newest Sciton laser in January 2017. The Halo is ... non-ablative and ablative wavelengths for exceptional results. Outperforming more traditional lasers, the innovative ...
(Date:12/5/2016)... ... December 05, 2016 , ... Researchers at Johns Hopkins ... growing brains of young athletes. Over the course of three years, researchers will study ... mouth guards. The mouth guards, equipped with special sensors, will track the location and ...
(Date:12/5/2016)... ... December 05, 2016 , ... ... provide alerting technology to Central Illinois Health Information Exchange (CIHIE) using its ... funds as the sole sub-recipient participating with the Illinois Health Information Exchange ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... Dec. 5, 2016 Spain Glaucoma Surgery Devices ... report, "Spain Glaucoma Surgery Devices Market Outlook to 2022", ... Devices market. The report provides value, in millions of ... within market segements - Canaloplasty Micro Catheters and Glaucoma ... and distribution shares data for each of these market ...
(Date:12/5/2016)... Calif. , Dec. 5, 2016 Sangamo BioSciences, ... genome editing, announced the presentation of preclinical and manufacturing data ... at the 58 th Annual Meeting of the American ... Diego, CA , from December 3-6, 2016. ... of hemophilia A which we believe is highly competitive, and ...
(Date:12/5/2016)... 2016  Cornerstone Pharmaceuticals, Inc., a privately held, ... two Phase I trials evaluating its lead compound, ... meeting of the American Society of Hematology (ASH) ... The two datasets show encouraging efficacy and safety ... and T-cell non-Hodgkin,s lymphoma (T-cell NHL), respectively, supporting ...
Breaking Medicine Technology:
Cached News: