HOME >> MEDICINE >> NEWS
New insight into cause of Crohn's disease

UK scientists have found evidence that suggests Crohn's disease is caused by a weak immune response. The researchers, who report their findings in an Article in this week's issue of The Lancet, also suggest that sildenafil (Viagra) might help in the treatment of the disease.

Crohn's disease is a chronic inflammatory disorder that causes ulcerations in the small and large intestines. Many scientists consider Crohn's to be an autoimmune disease--an illness that occurs when the body tissues are attacked by its own immune system. However, Anthony Segal (University College London, UK) and colleagues have found that, counter intuitively, the inflammation in Crohn's arises due to a weak immune response.

The investigators looked at the quantities of neutrophils (white blood cells) that patients with Crohn's disease produce in response to trauma at sites in the bowel (intestinal biopsy) and on the skin surface (skin abrasion). They found that in response to trauma, Crohn's disease patients produced much lower quantities of neutrophils and inflammatory mediators when compared with healthy individuals. Cultured blood cells were also abnormal in the patients. To test the inflammatory response to bacteria, the team also measured local inflammatory and blood flow changes in participants after injecting a harmless form of Escherichia Coli under their skin. In the healthy controls, blood flow in the area of inflammation increased approximately ten-fold by 24 hours. Crohn's disease patients, however, had much lower blood flow than controls. The researchers found that the abnormally low blood flow in Crohn's patients could be corrected by treatment with Viagra, indicating a possible role for the drug in the treatment of the disease.

The authors believe that in Crohn's disease, reduced or delayed recruitment of neutrophils to sites at which bacteria penetrate the intestinal wall might lead to the persistence of bacteria and other organic debris in the tissue.
'"/>

Contact: Joe Santangelo
j.santangelo@elsevier.com
212-633-3810
Lancet
23-Feb-2006


Page: 1 2

Related medicine news :

1. Sports concussion research using fMRI provides insight for safe return-to-play decisions
2. Better insight into brain anatomical structures
3. New insights into chronic inflammation and atherosclerosis
4. New insights into autoimmunity and depression
5. NIAID media availability: Examining genetic variability of malaria parasite offers insight
6. Functional brain imaging insights from UC San Diego grad student
7. More insight into Alzheimers disease with Stanford discovery of possible cause
8. Sticky proteins provide new insight into drug action
9. Laser probe of a brain pigments anatomy may offer insight into Parkinsons disease
10. New insights into the impact of pregnancy on inflammatory arthritis
11. Amnesiac study offers insights into how working memory works

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/4/2016)... ... 04, 2016 , ... Fertility Centers of New England announced today the opening ... Fertility Center provides convenient access to care for patients seeking fertility treatment in Maine. ... Wellness Comprehensive Care in Portland,” said Fertility Centers of New England President and CEO, ...
(Date:5/3/2016)... ... May 04, 2016 , ... An ... is reaching the global health community through expanding activities that embrace training, standards, ... in the resource-limited countries. , In support of this important work, ...
(Date:5/3/2016)... ... 03, 2016 , ... Today at its Annual Technology & ... Pulido, R.Ph., Co-Founder of NCPDP and member of the NCPDP Foundation Board of ... Specialist, Office of the National Coordinator for Health Information Technology (ONC). NCPDP’s Champion ...
(Date:5/3/2016)... ... 2016 , ... Calvary Hospital recently hosted a reception to mark a new ... located at Mary, Manning Walsh Home (MMW) in Manhattan. , During the school ... an hour, once a week. The music brings a lot of joy to the ...
(Date:5/3/2016)... ... 03, 2016 , ... Sandbox, one of the nation’s leading ... the newly created position of executive vice president, chief creative officer.     , In ... Chicago and LA offices. He reports to Nancy Finigan, president of those offices. ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... Mo. , May 3, 2016 ... Medical Center,s Institute for Advancing Medical Innovation (IAMI) ... commercialize new drugs, diagnostics and medical devices. ... BioNovus Innovations with rights to license, develop and ... "This partnership represents a ...
(Date:5/3/2016)... May 3, 2016   BIOTRONIK , a ... announced Food and Drug Administration (FDA) approval of ... provides heart failure patients with access to diagnostic ... have remote monitoring with daily automatic transmission and ... rate in response to physiological demands. ...
(Date:5/3/2016)... May 3, 2016 According to ... Share, Development, Growth and Demand Forecast to 2022 - ... Strength (High Field, Very High Field, Low to Mid ... and Neck, Spine, Musculoskeletal, Vascular, Breast, Pelvic and Abdomen, ... resonance imaging (MRI) market was valued at $5,351.7 million ...
Breaking Medicine Technology:
Cached News: