HOME >> MEDICINE >> NEWS
New insights into the impact of injury on cartilage cells

Documented in extensive studies, backed by the anecdotal evidence of professional athletes, impact injury to joints causes degeneration of cartilage. In most cases, the eventual result is the pain, stiffness, and compromised mobility of osteoarthritis (OA). Yet, questions remain surrounding the role of the inflammatory system in the cartilage destruction following mechanical trauma.

Tissue damage typically stimulates an influx of leukocytes, white blood cells known for promoting tissue regeneration and healing--to tissue protecting organs. However leukocytes can be a double edged sword. In the May 2006 issue of Arthritis & Rheumatism (http://www.interscience.wiley.com/journal/arthritis), researchers at Baylor College of Medicine and the Michael E DeBakey Veterans Affairs Medical Center in Houston, Texas, present the results of a study to test the hypothesis that leukocytes extend the zone of damage and cell death in cartilage after an acute injury.

The research team began with a collection of dog bones--the hind knee joints of 24 fresh young adult cadaver canines. Within one hour after death, each bone was subjected to impact injury with a metal weight, determined sufficient to cause cartilage damage without shattering the bone. A comparable collection of cadaver canine bones was preserved to serve as controls. All of the knee joints were cultured with blood leukocytes from the same dogCartilage biopsies were taken at various intervals between 12 hours and 7 days.

Among the assaulted bones, approximately half of the chondrocytes, or cartilage cells, died within 7 days. In the uninjured bones, over 90 percent of the chondrocytes survived. A surprising finding was the reduced viability of cartilage cells located well outside the vicinity of direct impact.
'"/>

Contact: Amy Molnar
amolnar@wiley.com
John Wiley & Sons, Inc.
28-Apr-2006


Page: 1 2

Related medicine news :

1. New insights into chronic inflammation and atherosclerosis
2. New insights into autoimmunity and depression
3. Functional brain imaging insights from UC San Diego grad student
4. New insights into the impact of pregnancy on inflammatory arthritis
5. Amnesiac study offers insights into how working memory works
6. Genetic insights may explain retinal growth, eye cancer
7. New strategy developed to study disease: Reveals insights into cancer and treatment leads
8. Wellcome brain insights
9. New insights into the link between rheumatoid arthritis and cancer
10. New insights into cost-effectiveness of implanted heart device
11. New insights into role of tumor necrosis factor on sex hormone production in rheumatoid arthritis

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New insights into the impact injury cartilage cells

(Date:10/30/2014)... Steven Reinberg HealthDay Reporter ... therapy to men with prostate cancer who also have certain ... heart-related cause, a new study suggests. , , The therapy in ... prostate cancer to reduce levels of male hormones to prevent ... in the current research, this hormone therapy was linked to ...
(Date:10/30/2014)... October 30, 2014 Dr. Joseph Furlin MD, ... website for his practices; OB GYN in Melrose Park, ... This website contains important information about each of the ... as downloadable patient forms in English and Spanish. The ... service pages on the website provide Dr. Furlin’s patients with ...
(Date:10/30/2014)... Beach, California (PRWEB) October 30, 2014 ... nutrtion bars are now available through a unique service ... online site designed to empower the everyday athlete. The ... worlds best athletes and created a system to pass ... excited to see REV’D® is now available on The ...
(Date:10/30/2014)... 30, 2014 Sound Telecom, a leader in ... will assist people any time they wonder, “Should I use ... answer by leading them through a series of yes or ... initial query. , There are many considerations and scenarios that ... an answering service . This decision infographic serves as ...
(Date:10/30/2014)... Dennis Thompson HealthDay Reporter ... lots of milk could be bad for your health, a ... calcium in milk can help strengthen bones and prevent osteoporosis. ... to recommend milk as part of a healthy diet. ... milk did not protect men or women from bone fractures, ...
Breaking Medicine News(10 mins):Health News:Hormone Therapy May Up Heart-Related Deaths in Some Prostate Cancer Patients 2Health News:Hormone Therapy May Up Heart-Related Deaths in Some Prostate Cancer Patients 3Health News:Dr. Joseph Furlin Launches New Website with Information about Care Services 2Health News:Nutrition Experts at TheFeed.com Get REV'D 2Health News:Nutrition Experts at TheFeed.com Get REV'D 3Health News:Sound Telecom Produces Decision Infographic to Aid Businesses 2Health News:Is Milk Your Friend or Foe? 2Health News:Is Milk Your Friend or Foe? 3
(Date:10/30/2014)... 30, 2014  Zimmer Holdings, Inc. (NYSE: ... executive leadership team and organizational structure of the combined ... also announced that the combined organization will leverage the ... Zimmer Biomet, with the new brand to be rolled ... the merger.  The future leadership team is committed to ...
(Date:10/30/2014)... -- CVS Health (NYSE: CVS ) announced today ... regional health systems to enhance access to high-quality, affordable health ... Health System in Alabama ; Community Health ... Pennsylvania , Northwest Medical Center, including Oro Valley ... in Tennessee ; and Premier Health in ...
(Date:10/30/2014)... 2014  CytRx Corporation (NASDAQ: CYTR ... in oncology, today announced an upcoming presentation highlighting ... aldoxorubicin.  The presentation, titled, "Drug Conjugates Bind Covalently ... by Sant P. Chawla , M.D., F.R.A.C.P., ... investigator of the Company,s ongoing global, pivotal Phase ...
Breaking Medicine Technology:Zimmer Announces Executive Leadership Team and New Name of Combined Company Following Closing 2Zimmer Announces Executive Leadership Team and New Name of Combined Company Following Closing 3Zimmer Announces Executive Leadership Team and New Name of Combined Company Following Closing 4Zimmer Announces Executive Leadership Team and New Name of Combined Company Following Closing 5Zimmer Announces Executive Leadership Team and New Name of Combined Company Following Closing 6Zimmer Announces Executive Leadership Team and New Name of Combined Company Following Closing 7Zimmer Announces Executive Leadership Team and New Name of Combined Company Following Closing 8Zimmer Announces Executive Leadership Team and New Name of Combined Company Following Closing 9CVS Health Announces New Clinical Affiliations with Leading Regional Health Systems 2CVS Health Announces New Clinical Affiliations with Leading Regional Health Systems 3CVS Health Announces New Clinical Affiliations with Leading Regional Health Systems 4CytRx Announces Oral Presentation at 2014 Chemotherapy Foundation Symposium 2CytRx Announces Oral Presentation at 2014 Chemotherapy Foundation Symposium 3CytRx Announces Oral Presentation at 2014 Chemotherapy Foundation Symposium 4
Cached News: