New insights into the impact of injury on carti...( In cartilage samples taken 6 to 9 mm ...),Health

In cartilage samples taken 6 to 9 mm from the impact site, and even in samples taken 10 mm or more from the impact site, these critical cells to tissue renewal had largely been killed off by leukocytes. The real culprit, however, was the leukocytes' generation of noxious nitric oxide (NO).

Is there a way to stop the leukocyte-mediated murders of chondrocytes? To explore this critical question, the researchers conducted more experiments on the dog bone cultures. They found that the killing of cartilage cells could be averted by desferoxamine, chemical thay=t blocks production of NO, and by anti-CD18 antibodies, which block the Velcro-like adhesion molecules that white cells use to adhere to other cells.

"Our findings have interesting clinical implications," observes the study's leading author, Dr. D. M. Green. "First, we have demonstrated that acute mechanical injury of the articular surface causes death of chondrocytes located at a distance from the site of trauma. Second, up-regulation of adhesion molecules on the affected chondrocytes allows leukocytes to adhere and to extend the zone of injury beyond the impact site. Thus, the data in this study suggest that therapies to reduce acute influx of leukocytes into damaged cartilage should be considered in the future when treating osteochondral injuries."

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Contact: Amy Molnar
amolnar@wiley.com
John Wiley & Sons, Inc.
28-Apr-2006

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