HOME >> MEDICINE >> NEWS
New insights into the link between rheumatoid arthritis and cancer

An inflammatory disease of the immune system, rheumatoid arthritis (RA) is associated with increased occurrence of lymphoma--or cancers of the lymphatic system, which plays an integral role in the body's ability to fight infection. While various studies have affirmed this link, none have been able to pinpoint the specific effects of disease activity on lymphoma risk, let alone distinguish them from the effects of disease treatment.

Are certain RA patients more vulnerable to developing lymphoma? Do certain RA therapies--from standard NSAIDs (nonsteroidal anti-inflammatory drugs) and DMARDs (disease-modifying antirheumatic drugs) to novel immunosuppressive agents like TNF (tumor necrosis factor) blockers--work to alleviate or aggravate lymphoma risk? On a quest for answers, researchers in Sweden conducted the largest investigation of the link between RA and lymphoma to date. Their findings, featured in the March 2006 issue of Arthritis & Rheumatism (http://www.interscience.wiley.com/journal/arthritis), indicate a substantially increased risk of lymphoma among patients with severe RA. Very high and prolonged inflammatory activity, not its treatment, is the major risk factor.

Drawing their sample from a national register of nearly 75,000 RA patients, the research team analyzed the medical records and case histories of 378 RA patients afflicted with malignant lymphoma between 1964 and 1995 and 378 individually matched, lymphoma-free controls. Using statistical analysis, the relative risks or odds ratios for lymphoma were assessed for three different levels of overall disease activity--low, medium, or high--based on disease duration and swollen and tender joint counts. Odds ratios for lymphoma were also compared to treatment in broad categories: any DMARD, any NSAID, aspirin, oral steroids, injected steroids, and cytotoxic drugs. No patient in the sample had received anti-TNF the
'"/>

Contact: Amy Molnar
amolnar@wiley.com
John Wiley & Sons, Inc.
27-Feb-2006


Page: 1 2 3

Related medicine news :

1. New insights into chronic inflammation and atherosclerosis
2. New insights into autoimmunity and depression
3. Functional brain imaging insights from UC San Diego grad student
4. New insights into the impact of pregnancy on inflammatory arthritis
5. Amnesiac study offers insights into how working memory works
6. Genetic insights may explain retinal growth, eye cancer
7. New insights into the impact of injury on cartilage cells
8. New strategy developed to study disease: Reveals insights into cancer and treatment leads
9. Wellcome brain insights
10. New insights into cost-effectiveness of implanted heart device
11. New insights into role of tumor necrosis factor on sex hormone production in rheumatoid arthritis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/15/2018)... ... November 15, 2018 , ... Made of Millions, a nonprofit ... exhibit — Seen — to New York this month. The event will feature a ... to create environment that showcases mental health issues in a more experiential way,” said ...
(Date:11/15/2018)... ... 15, 2018 , ... Over the last decade, SABRE , the global ... for National Breast Cancer Foundation (NBCF) . A mission-driven organization and proud partner ... proceeds have helped launch the National Mammography Program which has provided almost ...
(Date:11/15/2018)... Ky. (PRWEB) , ... November 15, 2018 , ... ... Turner have recently invited four more skilled medical professionals to join their ... includes more procedures at its skin clinic, Skin Chic, and is expanding its ...
(Date:11/15/2018)... ... 15, 2018 , ... Mothers and babies across California are ... that puts vital health education resources right at their fingertips. The initiative between ... Plan effective 1/1/19), an affiliate of Blue Shield of California, and the ...
(Date:11/15/2018)... ... ... The National Cancer Institute estimates that 1.7 million new cases of cancer will ... and we typically associate the disease with old age, about 9 percent of cancers ... advanced therapies, increasing numbers of these patients survive their disease and face the consequences ...
Breaking Medicine News(10 mins):
(Date:11/15/2018)... ... November 15, 2018 , ... Ric Henry, President and Owner of Pendulum, ... or Consequences, New Mexico on Friday, November 2, 2018. Ric, who opened Sierra as ... of Directors. , Sierra Health Care Center has become known as one of ...
(Date:11/15/2018)... ... 15, 2018 , ... American Bancard, dba TouchSuite announced today ... Canadian markets. TouchSuite will underwrite merchants selling CBD products online or in ... of the risks associated with the industry. CBD accounts will be boarded via ...
(Date:11/15/2018)... (PRWEB) , ... November 15, 2018 , ... Joint ... orthopedic institution in the Midwest, is one of only nine group practice centers in ... Two of the most common surgeries Americans undergo each year—knee and hip replacement—will be ...
Breaking Medicine Technology:
Cached News: