HOME >> MEDICINE >> NEWS
New 'litmus test' could aid discovery of anti-cancer drugs

EVANSTON, Ill. --- Using the unusual color properties of gold at the nanoscale, scientists at Northwestern University have developed a "litmus test" for DNA and small molecule binding that eventually could be used by pharmaceutical companies to rapidly identify promising candidates for new anti-cancer drugs.

The detection system, called colorimetric screening, can be used to detect a variety of targets, such as DNA, small molecules and proteins, that bind to DNA, and the strength of the bond is indicated by a simple color change.

In a paper reported online today (March 28) by the Journal of the American Chemical Society (JACS), the research team used the colorimetric method to screen for molecules that can facilitate the formation of a special form of DNA called a triple helix. Triple helix DNA involves three strands rather than the two associated with normal DNA. However, unlike double helix DNA, the triple helix is unstable alone and requires a small molecule triplex binder to increase its stability. This research builds on work reported March 6 in the German journal Angewandte Chemie in which the same method was used to screen small molecules for their binding affinity to duplex DNA.

"Pharmaceutical companies are targeting DNA for different therapies, and they need to identify DNA or small molecules that selectively bind to DNA to turn on or off the gene expression related to a particular disease," said Chad A. Mirkin, George B. Rathmann Professor of Chemistry, professor of medicine and professor of materials science and engineering, who led both studies. "Our method, which is simpler, faster and more convenient than conventional methods, should help researchers zero in on potential anti-cancer agents from their large libraries of candidates more quickly."

In the JACS paper, the researchers demonstrated that when a triplex binder binds to a given DNA triple helix in solution the strength of that binding event can be detected by
'"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
28-Mar-2006


Page: 1 2 3

Related medicine news :

1. Seat belt injuries could signal more serious trauma in children
2. Using MRI for diagnosis could help prevent breast cancer progression
3. Metabolic study in mice could lead to good cholesterol boosters
4. Miniature implanted devices could treat epilepsy, glaucoma
5. Health reform bills could improve quality and efficiency, but fall short of national plan
6. Experts predict Tamiflu could halve the pandemic influenza death toll versus no intervention
7. Split the difference: Pill-splitting study looks at cost-saving step that could be used by millions
8. Oxygen trick could see organic costs tumble
9. New study could bring relief to sweltering city slickers
10. Decision aid tool could cut the number of Caesarean sections by 4000 a year
11. Papillomavirus vaccine could substantially reduce cervical cancer incidence

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New litmus test could aid discovery anti cancer drugs

(Date:4/19/2015)... April 19, 2015 The American Institute ... with PROSHRED Security (“PROSHRED”) to host its second annual, ... shred their personal documents in order to raise funds ... , The June 6th event is being held at ... 2pm local time. The time will vary at select ...
(Date:4/19/2015)... (PRWEB) April 19, 2015 HealthPostures, LLC ... announces that it will exhibit it’s pioneering ergonomics products ... and the Iowa-Illinois Safety Council Professional Development Conference and ... the TaskMate EZ are used in volume by call ... , Built to clamp to a desk, the ...
(Date:4/18/2015)... Carinsurancesavings.biz has released a new blog post explaining ... Spring. , Spring can be a great season ... sure they compare the newest policies before deciding on ... about Spring car insurance offers by reading the newly ... becoming more and more popular. Many insurance brokerage websites ...
(Date:4/18/2015)... 18, 2015 Insuranceautoquote.info has released a ... auto insurance quotes . , Clients can review ... website. The online environment provides important advantages for clients ... , Drivers who do not have coverage for their ... any season, day or hour. Many agencies offer important ...
(Date:4/18/2015)... the past few weeks, TheBeautyPlace.com has been undergoing maintenance ... run maintenance on our shipping facilities to update software ... Director. "It disrupted our regular shipping schedule but we ... track after having completed the maintenance." , Now, TheBeautyPlace.com ... has not allowed some calls to come in through ...
Breaking Medicine News(10 mins):Health News:2015 Annual Nationwide "Shred Cancer" Shredding Event 2Health News:HealthPostures' TaskMate Products to be Exhibited at the Wisconsin and Iowa-Illinois Safety Conferences 2Health News:Auto Insurance Plans Are Cheaper During Spring! 2Health News:Clients Can Review Car Insurance Quotes Online To Find Low Cost Offers! 2Health News:TheBeautyPlace.com Temporary Number Available 2
(Date:4/16/2015)... SHENZHEN, China , April 16, 2015 /PRNewswire/ ... a leading developer, manufacturer, and marketer of medical ... with the Securities and Exchange Commission an Annual Report ... for the year ended December 31, 2014. An electronic ... is available on Mindray,s investor relations website at  ...
(Date:4/16/2015)... , April 16, 2015  Amgen (NASDAQ: ... first quarter financial results on Tuesday, April 21, 2015, ... announcement will be followed by a conference call with ... the call from Amgen will be Robert A. ... members of Amgen,s senior management team. Live ...
(Date:4/16/2015)... Colo. , April 16, 2015  Rosewind ... completed a reverse merger with a newly formed ... an initial focus on addressing urological disorders. The ... Aytu BioScience Inc., has commenced operations and incorporates ... Luoxis Diagnostics.  The Company,s strategy is to build ...
Breaking Medicine Technology:Mindray Files Annual Report on Form 20-F with the U.S. Securities and Exchange Commission 2Amgen Announces Webcast Of 2015 First Quarter Financial Results 2Rosewind Corporation Shifts Focus to Develop Late-Stage Therapeutics for Urological and Related Conditions 2Rosewind Corporation Shifts Focus to Develop Late-Stage Therapeutics for Urological and Related Conditions 3
Cached News: