HOME >> MEDICINE >> NEWS
New 'litmus test' could aid discovery of anti-cancer drugs

EVANSTON, Ill. --- Using the unusual color properties of gold at the nanoscale, scientists at Northwestern University have developed a "litmus test" for DNA and small molecule binding that eventually could be used by pharmaceutical companies to rapidly identify promising candidates for new anti-cancer drugs.

The detection system, called colorimetric screening, can be used to detect a variety of targets, such as DNA, small molecules and proteins, that bind to DNA, and the strength of the bond is indicated by a simple color change.

In a paper reported online today (March 28) by the Journal of the American Chemical Society (JACS), the research team used the colorimetric method to screen for molecules that can facilitate the formation of a special form of DNA called a triple helix. Triple helix DNA involves three strands rather than the two associated with normal DNA. However, unlike double helix DNA, the triple helix is unstable alone and requires a small molecule triplex binder to increase its stability. This research builds on work reported March 6 in the German journal Angewandte Chemie in which the same method was used to screen small molecules for their binding affinity to duplex DNA.

"Pharmaceutical companies are targeting DNA for different therapies, and they need to identify DNA or small molecules that selectively bind to DNA to turn on or off the gene expression related to a particular disease," said Chad A. Mirkin, George B. Rathmann Professor of Chemistry, professor of medicine and professor of materials science and engineering, who led both studies. "Our method, which is simpler, faster and more convenient than conventional methods, should help researchers zero in on potential anti-cancer agents from their large libraries of candidates more quickly."

In the JACS paper, the researchers demonstrated that when a triplex binder binds to a given DNA triple helix in solution the strength of that binding event can be detected by
'"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
28-Mar-2006


Page: 1 2 3

Related medicine news :

1. Seat belt injuries could signal more serious trauma in children
2. Using MRI for diagnosis could help prevent breast cancer progression
3. Metabolic study in mice could lead to good cholesterol boosters
4. Miniature implanted devices could treat epilepsy, glaucoma
5. Health reform bills could improve quality and efficiency, but fall short of national plan
6. Experts predict Tamiflu could halve the pandemic influenza death toll versus no intervention
7. Split the difference: Pill-splitting study looks at cost-saving step that could be used by millions
8. Oxygen trick could see organic costs tumble
9. New study could bring relief to sweltering city slickers
10. Decision aid tool could cut the number of Caesarean sections by 4000 a year
11. Papillomavirus vaccine could substantially reduce cervical cancer incidence

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/9/2016)... Florida (PRWEB) , ... February 09, 2016 , ... ... cold therapy products, announced today the introduction of the newly designed, innovative shoulder ... comfort and better cold therapy coverage for the injured arm and shoulder to ...
(Date:2/9/2016)... ... February 09, 2016 , ... Sir Grout, the leading ... proud to announce that many of their franchises have received the Super Service ... surface restoration franchises received customer recognition through positive reviews and testimonials, as well ...
(Date:2/9/2016)... ... February 09, 2016 , ... The Brain ... won. A team from 21st Century Medicine (21CM) ( http://www.21cm.com/ ), spearheaded ... delicate neural circuits of an intact rabbit brain for extremely long-term storage using ...
(Date:2/8/2016)... , ... February 08, 2016 , ... ... with BASF Human Nutrition into the Food & Beverage and ... been BASF’s channel partner throughout Canada and USA geographies east of the Rocky ...
(Date:2/8/2016)... ... February 08, 2016 , ... The Valentine’s Season is famous for gift giving with flowers, chocolates ... they are loved. This year, for more than 5.6 million Americans suffering with Alzheimer’s, ... be enough to remind them of the lives they’ve led and the people they’ve touched. ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... LONDON , Feb.8, 2016 Aesthetic Devices ... GlobalData,s Medical Devices sector report, "Aesthetic Devices - Medical ... Devices currently in pipeline stage. This ... secondary and primary research by GlobalData,s team of industry ... be removed or altered based on the availability and ...
(Date:2/8/2016)... 8, 2016  Neurocrine Biosciences, Inc. (Nasdaq: NBIX ... fourth quarter and year-end 2015 results after the Nasdaq ... then host a live conference call and webcast to ... Thursday afternoon, February 11, 2016 at 4:30 p.m. Eastern ... --> http://www.neurocrine.com . --> Participants ...
(Date:2/8/2016)... , Feb. 8, 2016   GS1 US ... professionals to guide them through GS1 Standards implementation to ... Administration (FDA) Unique Device Identification (UDI) rule. ... US; Beth Gibson , senior director industry development, ... industry development director, GS1 US --> ...
Breaking Medicine Technology:
Cached News: