HOME >> MEDICINE >> NEWS
New mechanism underlying pain found

thmic transmission."

Ion channels are openings that exist within a cell that allow the passage of certain ions into a cell to regulate activity. It is believed that hundreds of different types of ion channels exist in the body, each with a distinct responsibility for sending a specific message, and that specific pacemaker channels exist in peripheral nerves as well as in the heart and the central nervous system. In the heart, for instance, signals generated by pacemaker channels stimulate the heart muscle to contract, and in the brain, they control sleep and waking. Made up of glycoproteins, or proteins with sugar molecules attached, pacemaker channels -- also known as HCN channels (Hyperpolarization activated, Cyclic Nucleotide-gated cation channels) -- allow the entrance of sodium ions into the cell based on the configuration of the protein. Entry of sodium ions can trigger electrical activity in both cardiac cells and neurons.

"We think we have only scratched the surface in this area, as pacemaker channels may also play a role in inflammatory pain as well as other types, " said Dr. Wickenden. "More research is needed before this will translate to patient benefit, but the better understanding we've gained of the mechanism can enable us to narrow our focus."


'"/>

Contact: Ernie Knewitz
eknewitz@prdus.jnj.com
908-927-2953
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
15-Oct-2006


Page: 1 2

Related medicine news :

1. MU researchers find mechanisms that may unlock answers to Alzheimers disease
2. Study reveals aspirins colorectal cancer prevention mechanism
3. New mechanism identified for resistance to targeted lung cancer drugs
4. Important mechanism identified in the formation of blood vessels
5. Brain studies reveal the mechanisms of the voluntary control of visual attention
6. Researchers discover mechanism that determines when detailed memories are retained
7. Study identifies possible mechanism for brain damage in Huntingtons disease
8. Carnegie Mellon receives NIMH/NSF grant to examine mechanisms that underlie neuronal synchronization
9. Study uncovers mechanism of drug resistance in form of lung cancer
10. A novel mechanism of manganese-induced neurological dysfunction discovered
11. Drug triggers bodys mechanism to reverse aging effect on memory process

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/27/2016)... ... 2016 , ... W.S. Badger Co. Inc ., the maker of certified ... as one of the best small businesses for new dads by Fatherly, the digital ... businesses providing progressive benefits to new parents on the organization’s 2016 Best Places ...
(Date:5/27/2016)... ... May 27, 2016 , ... An educational campaign aimed at ... stories, courtesy of awareness-driven celebrities and thought leaders. It also provides insight to ... industry leaders such as Bioness. , As patients feel increasingly concerned about ...
(Date:5/27/2016)... ... 27, 2016 , ... Aimed at nurses and employees in the health care ... leaders in the nursing and health care industry. It also provides insight to the ... University. , As the nursing industry is coming out of one of the ...
(Date:5/26/2016)... ... , ... There are many ways to cook a hot dog, but new ... prefer their dogs straight off the grill. Of the 90 percent of Americans who ... cook a hot dog, far outpacing other cooking methods such as steaming (12 percent), ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... property (IP) to its specialty academic programs. , Answering to the increasing demand ... certificate programs in health law, and environmental and land use law. ,  , ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25, 2016 MedDay, a ... announces that an oral presentation entitled "High doses of biotin ... trial" will be given by Professor Ayman Tourbah , ... Congress of the European Academy of Neurology (EAN) in ... related disorders 3" will take place on Sunday, 29 May ...
(Date:5/24/2016)... , May 24, 2016 ... beide primären Endpunkte und ... Überlegenheit in ‚ausgezeichneter plus guter ... Colons    ,      (Logo: ... gab heute neue positive Daten von der MORA-Studie ...
(Date:5/24/2016)... Celsion Corporation (NASDAQ: CLSN ... an update on its ongoing OVATION study, a ... the Company,s DNA-based immunotherapy, with the standard of ... advanced ovarian cancer who will undergo neoadjuvant chemotherapy ... IL-12 DNA plasmid vector formulated as a nanoparticle ...
Breaking Medicine Technology:
Cached News: