HOME >> MEDICINE >> NEWS
New method of administering anti-cancer drug may be more effective, safer

CHAPEL HILL -- A novel way of administering an anti-cancer drug to bone-marrow transplant patients using continuous infusion may be more effective and safer than the method currently used, new study findings indicate.

The new method achieves more predictable, stable drug levels in patients than the current method and could eventually allow doctors to more accurately adjust doses to accommodate individual differences in metabolism, thus increasing treatment effectiveness while avoiding side effects, said University of North Carolina at Chapel Hill researchers.

The findings were presented at the 2005 annual meeting of the American Society of Clinical Oncology, held May 13 through 17 in Orlando, Fla. The drug busulfan is used in leukemia patients to kill cancerous cells before bone-marrow transplant. Currently, it is administered in intermittent intravenous doses, typically via two-hour infusions of the drug every six hours. Previous studies have reported that frequent dose adjustments are needed to maintain the desired level of drug in patients and that metabolism of the drug varies from patient to patient.

"The new continuous-infusion method achieved more predictable levels of the drug than does the usual delivery method," said Dr. Thomas C. Shea, professor of medicine at UNC, director of the Bone Marrow Transplant Program at the UNC Health Care System and a member of the UNC Lineberger Comprehensive Cancer Center.

"In the relatively small number of patients tested with continuous infusion, there didn't appear to be a change in concentration or clearance of the drug during the 90-hour infusion period."

In 12 patients scheduled for bone marrow transplants, UNC researchers administered a single busulfan test dose of 0.8 mg/kg adjusted body weight over two hours. Blood concentrations of the drug were measured every two hours for eight hours following that test dose.

Then researchers administered busulfan by the novel method - patient
'"/>

Contact: Leslie H. Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
18-May-2005


Page: 1 2

Related medicine news :

1. New oxidation methods streamline synthesis of important compounds
2. U of M researchers discover new method to combat HIV
3. New prevention, treatment methods for patients with painful bowel inflammation
4. Scientists develop method to track immune system enzyme in live animals
5. VA should revise its methods for evaluating and rating PTSD in veterans
6. Northwestern chemists develop new method for synthesizing anti-cancer flavonoids
7. Scientists develop method to remove prion infectivity from scrapie-infected blood
8. PhD researcher develops inexpensive, sustainable production method in just 2 years
9. Researchers develop novel method for treatment of sickle cell disease
10. Developing better methods of blinding doctors and patients in clinical trials
11. Cancer survival compromised by poor staging methods

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/12/2016)... ... February 12, 2016 , ... Each year, the American Physical Therapy Association (APTA) ... at the Anaheim Convention Center. Almost 10,000 physical therapists across the country are expected ... learn more about their chosen field and network with their colleagues. As in ...
(Date:2/12/2016)... ... February 12, 2016 , ... ... at Zuckerberg San Francisco General Hospital on April 5-7. The series is a ... create new habits. The workshops cover a broad range of topics, including coaching ...
(Date:2/12/2016)... ... February 12, 2016 , ... AssureVest Insurance Group, a locally ... a charity drive that will raise funds earmarked to purchase computers and software for ... School. , “My school is in a low-income area and has more than 60 ...
(Date:2/12/2016)... , ... February 12, 2016 , ... ... the Pittsburgh metro area, celebrates the beginning of the latest charity campaign in ... social skills through art. Donations to this worthy cause are currently being accepted ...
(Date:2/12/2016)... ... February 12, 2016 , ... ... and surrounding communities by continuing it’s commitment to act as Agents of Change ... organization works closely with area homeless families to fulfill immediate needs and help ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... 2016 - Cardiac Marker ... Medicine and Cancer Therapy. - European Point of ... Markets. - Key Diagnostic Testing Markets. - ... in Genetic Testing. - Molecular Diagnostics in Infectious ... Over-the-Counter Diagnostic Products World Markets. - Point of ...
(Date:2/11/2016)... Stem cells are primitive cells found in ... the capacity to differentiate into mature cell types Stem ... first mouse embryonic stem cells were derived from embryos ... the first culturing of embryonic stem cells from non-human ... until 2006 As a result of these discoveries, stem ...
(Date:2/11/2016)... , Feb. 11, 2016 Laboratory ... used in laboratories. These may range from microscope slides ... glassware is made from borosilicate glass because of its ... on the other hand, started gaining popularity over the ... easier to replace glass with plastic in several applications ...
Breaking Medicine Technology:
Cached News: