HOME >> MEDICINE >> NEWS
New oxidation methods streamline synthesis of important compounds

One of the fundamental challenges facing organic synthesis in the 21st century is the need to significantly increase the efficiency with which carbon frameworks can be constructed and functionalized. Chemists at the University of Illinois are helping to meet this challenge by developing a class of carbon-hydrogen catalysts that are highly selective, reactive and tolerant of other functionality.

The catalysts also offer a new strategy for streamlining the synthesis of important compounds, including drugs and pharmaceuticals, by avoiding the functional group manipulations required for working with oxidized materials.

We are creating a toolbox of catalytic reactions that allow us to go directly from a carbon-hydrogen bond to a carbon-oxygen bond or to a carbon-nitrogen bond, said M. Christina White, a professor of chemistry at Illinois. By offering fewer steps, fewer functional group manipulations and higher yields, this toolbox will change the way chemists make molecules.

Currently, chemists must make molecules by beginning with something that is already oxidized. But, having to start with that functionality means it must be carried and protected throughout the entire synthetic sequence. And that costs reagents, time, money and manpower, in addition to being inherently inefficient.

Unlike standard synthetic methods, we dont have to carry the functionality throughout the entire sequence, White said. Instead, we carry latent functionality as a carbon-hydrogen bond. Then, at a late stage in the synthesis, we remove the hydrogen and replace it with oxygen or nitrogen right where we need it for the next chemical reaction.

In the June 13 issue of the Journal of the American Chemical Society, White and graduate student Kenneth J. Fraunhoffer describe the catalytic pathway they used to synthesize a derivative of the chemotherapeutic reagent acosamine. They were able to eliminate all of the functional group manipulations
'"/>

Contact: James E. Kloeppel
kloeppel@uiuc.edu
217-244-1073
University of Illinois at Urbana-Champaign
2-Aug-2007


Page: 1 2

Related medicine news :

1. New prevention, treatment methods for patients with painful bowel inflammation
2. VA should revise its methods for evaluating and rating PTSD in veterans
3. Developing better methods of blinding doctors and patients in clinical trials
4. Cancer survival compromised by poor staging methods
5. National study compares delivery methods of schizophrenia medicines
6. Rhythm method may kill off more embryos than other methods of contraception
7. Studies report findings on colorectal cancer screening methods and survival rates
8. Cataract surgery rates and costs related to physician reimbursement methods
9. Prisoners should have access to proven HIV prevention methods
10. New screen-and-treat methods for cervical cancer significantly reduce cancer precursor lesions
11. Sandia researchers determine that common anthrax sampling methods need improvement

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/29/2017)... ... 2017 , ... A New York high tech innovator and a Canadian not-for-profit ... of Artificial Intelligence (AI) in helping nudge men forward to be more proactive about ... of the Canadian Men’s Health Foundation (CMHF), whose mission is to inspire men to ...
(Date:5/28/2017)... ... ... HYPERAMS, LLC announced it will perform the inventory liquidation of ... The sale began this week and the inventory is expected to sell quickly. ... medical accessories, including blood pressure cuffs, stethoscopes, CPR masks, as well as blank polos, ...
(Date:5/28/2017)... ... 28, 2017 , ... Viewers likely know Rob Lowe from such 80s hits ... for his work on NBC’s The West Wing and Parks and Recreation. But recently, ... “Informed,” which puts the spotlight on important modern-day issues that face today’s society. One ...
(Date:5/27/2017)... ... ... In any business, follow up is critical to success. It is the same ... there will always be some patients who can’t or won’t make a immediate decision. ... it comes to presenting treatment. After the patient leaves, most practices end up ...
(Date:5/26/2017)... NY (PRWEB) , ... May 26, 2017 , ... Mediaplanet ... & Wound Care" campaign in USA Today, which will educate readers on how to ... of the campaign, a large focus is placed on melanoma. Dancing with the Stars ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... Md. , May 10, 2017 CSSi, ... solutions for the clinical research industry, is proud to ... www.CSSiEnroll.com . The new website features both enriched content ... user experience and enhances the company,s already well-established position ... industry. "After many months of hard ...
(Date:5/9/2017)... , May 9, 2017  Semler Scientific, ... provides technology solutions to improve the clinical effectiveness ... results for the first quarter ended March 31, ... products enable our customers to identify when preventive ... intervene before events like heart attacks or strokes ...
(Date:5/6/2017)... , May 5, 2017  May is Stroke ... one of the most important methods to prevent a ... the Centers for Disease Control and Prevention, undetected and ... 1 Omron, the global leader in personal heart ... the elimination of heart attack and stroke and is ...
Breaking Medicine Technology:
Cached News: