HOME >> MEDICINE >> NEWS
New oxidation methods streamline synthesis of important compounds

One of the fundamental challenges facing organic synthesis in the 21st century is the need to significantly increase the efficiency with which carbon frameworks can be constructed and functionalized. Chemists at the University of Illinois are helping to meet this challenge by developing a class of carbon-hydrogen catalysts that are highly selective, reactive and tolerant of other functionality.

The catalysts also offer a new strategy for streamlining the synthesis of important compounds, including drugs and pharmaceuticals, by avoiding the functional group manipulations required for working with oxidized materials.

We are creating a toolbox of catalytic reactions that allow us to go directly from a carbon-hydrogen bond to a carbon-oxygen bond or to a carbon-nitrogen bond, said M. Christina White, a professor of chemistry at Illinois. By offering fewer steps, fewer functional group manipulations and higher yields, this toolbox will change the way chemists make molecules.

Currently, chemists must make molecules by beginning with something that is already oxidized. But, having to start with that functionality means it must be carried and protected throughout the entire synthetic sequence. And that costs reagents, time, money and manpower, in addition to being inherently inefficient.

Unlike standard synthetic methods, we dont have to carry the functionality throughout the entire sequence, White said. Instead, we carry latent functionality as a carbon-hydrogen bond. Then, at a late stage in the synthesis, we remove the hydrogen and replace it with oxygen or nitrogen right where we need it for the next chemical reaction.

In the June 13 issue of the Journal of the American Chemical Society, White and graduate student Kenneth J. Fraunhoffer describe the catalytic pathway they used to synthesize a derivative of the chemotherapeutic reagent acosamine. They were able to eliminate all of the functional group manipulations
'"/>

Contact: James E. Kloeppel
kloeppel@uiuc.edu
217-244-1073
University of Illinois at Urbana-Champaign
2-Aug-2007


Page: 1 2

Related medicine news :

1. New prevention, treatment methods for patients with painful bowel inflammation
2. VA should revise its methods for evaluating and rating PTSD in veterans
3. Developing better methods of blinding doctors and patients in clinical trials
4. Cancer survival compromised by poor staging methods
5. National study compares delivery methods of schizophrenia medicines
6. Rhythm method may kill off more embryos than other methods of contraception
7. Studies report findings on colorectal cancer screening methods and survival rates
8. Cataract surgery rates and costs related to physician reimbursement methods
9. Prisoners should have access to proven HIV prevention methods
10. New screen-and-treat methods for cervical cancer significantly reduce cancer precursor lesions
11. Sandia researchers determine that common anthrax sampling methods need improvement

Post Your Comments:
(Date:11/26/2014)... German scientists say carbon-based synthetic molecules used in ... looks and acts similar to asbestos-induced mesothelioma. Surviving Mesothelioma ... Click here to read it now. , ... Medicine in Hannover injected 500 lab rats with multi-walled ... developed mesothelioma , how quickly it developed appeared ...
(Date:11/26/2014)... November 26, 2014 Loffler Companies has ... Week in Imaging, an online information and news publication ... is the sixth consecutive year Loffler has earned this ... , The Elite Dealer Awards honor the best and ... year’s Elite Dealer honorees were chosen for their innovative ...
(Date:11/26/2014)... Senior Planning Services, providing “expert guidance ... organization providing the adult demographic education and access ... navigate the rough seas of applying for Medicaid. Part ... the topic of Medicaid eligibility and proper planning, while ... applying for this coverage. , Senior Planning Services ...
(Date:11/26/2014)... November 26, 2014 Call 866-997-4948 (Us-Canada ... or email the details on sales(at)researchmoz(dot)us , Researchmoz.us ... drug discovery market 2014" with deep study of the ... result of high blood sugar. The global glucose monitoring ... to the growing number of diabetics in the world. ...
(Date:11/26/2014)... 26, 2014 Louisiana Back Institute, ... specialists in minimally invasive spine surgery, announces today ... the rapidly growing provider network of orthopedic spine ... coincides with the network’s continuing success providing the ... Louisiana residents who are suffering from orthopedic spine ...
Breaking Medicine News(10 mins):Health News:Multi-walled Nanotubes Linked to Mesothelioma in New Study, According to Surviving Mesothelioma 2Health News:Loffler Companies Recognized as an Elite Dealer for Sixth Consecutive Year 2Health News:Senior Planning Services Teams Up with SeniorNet To Educate Seniors On Medicaid Planning 2Health News:Latest Report on Diabetes Market 2014 - Global Market Size, Share, Trends and Forecast by Researchmoz.us 2Health News:Latest Report on Diabetes Market 2014 - Global Market Size, Share, Trends and Forecast by Researchmoz.us 3Health News:Louisiana Back Institute Welcomes Dr. K. Samer Shamieh into Medical Provider Network 2
(Date:11/26/2014)... , Nov. 25, 2014  Array BioPharma ... announced that its Chief Executive Officer, ... following upcoming conferences.  The public is welcome ... on the Array BioPharma website:  www.arraybiopharma.com ... 2014Time:1:30 p.m.  Eastern Time Location: Palace Hotel, ...
(Date:11/26/2014)... YORK and HERZLIYA PITUACH, Israel, Nov. 25, ... "Immune" or "the Company"), a clinical stage biopharmaceutical ... of targeted therapeutics for the treatment of inflammatory ... its previously announced underwritten public offering of 3,450,000 ... of the Company,s common stock, par value $0.0001 ...
(Date:11/24/2014)... Nov. 24, 2014  CryoLife, Inc. (NYSE: CRY ... on cardiac and vascular surgery, announced today that it will ... Healthcare Conference on Wednesday, December 3, 2014 at The New ... . A live webcast of the Company,s presentation ... feature an overview of the company by Pat Mackin ...
Breaking Medicine Technology:Immune Pharmaceuticals Inc. Announces Closing Of Public Offering Of Common Stock And Warrants 2Immune Pharmaceuticals Inc. Announces Closing Of Public Offering Of Common Stock And Warrants 3Immune Pharmaceuticals Inc. Announces Closing Of Public Offering Of Common Stock And Warrants 4Immune Pharmaceuticals Inc. Announces Closing Of Public Offering Of Common Stock And Warrants 5CryoLife to Present at 26th Annual Piper Jaffray Healthcare Conference 2CryoLife to Present at 26th Annual Piper Jaffray Healthcare Conference 3
Cached News: