Researchers monitored two groups of platelets derived from whole blood donations. The first group of platelets was stored in plasma, while the second group was stored in the artificial preservative. On day seven, both groups of platelets met the current FDA requirements and the more stringent European requirements for use. Although both groups of platelets retained their quality for seven days, it's important to note that the platelets in the preservative had extremely low plasma levels.
The artificial preservative tested was unique because it contained glucose, which seems to be a key component in extending the shelf life of platelets. The preservative also contained sodium acetate and sodium bicarbonate.
"Until now, preservatives containing glucose have not been successfully used for platelet storage because glucose carmelizes during sterilization, and the only way to prevent carmelization is to lower the pH levels to a point that could be harmful to the platelet," says Sweeney.
Sweeney was able to use a glucose containing preservative without harming the platelets by adding sodium bicarbonate to the storage container. The sodium bicarbonate protected the platelets from exposure to low pH levels.
"Improvements in the quality and safety of blood products are continually being developed to enhance patient safety," Sweeney says. "Advances in platelet storage will pave the way for the next generation of blood products, such as artificial platelets."
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Contact: Megan Martin
mmartin@lifespan.org
401-793-7484
Lifespan
31-May-2006