New procedures more accurate in early diagnosis of GI cancers

CHICAGO, IL (May 15, 2005) -- Researchers have developed two new tests that are more accurate than current technologies in the early diagnosis of important gastrointestinal cancers. This research was presented today at Digestive Disease Week 2005 (DDW), the largest international gathering of physicians, researchers and academics in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery.

"The most important factor in treating any major cancer or gastrointestinal disorder is early detection and treatment," said Richard Rothstein, M.D., of Dartmouth Medical School. "These researchers are paving the way for the next generation of breakthrough diagnostics and procedures, further helping to improve the quality of life and ultimately save lives."

Serum Proteomic Fingerprints for Diagnosis of Gastric Cancer (Abstract 476)

Although stomach cancer is the world's second most deadly cancer, the medical community has yet to identify a reliable gastric tumor marker that would identify individuals genetically predisposed to cancer or individuals in the early stages of the disease. Researchers from the Chinese University of Hong Kong examined the ability of SELDI ProteinChip technology to accurately diagnose gastric cancer. This tool categorizes proteins and creates a unique "fingerprint" to diagnose cancer. This fingerprint represents a series of protein masses that can be used to differentiate between normal and diseased patient samples. Results of the study have demonstrated that serum proteomic fingerprinting may be a highly accurate diagnostic marker for gastric cancer.

The three-part study consisted of finding potential diagnostic markers and developing and validating a diagnostic model. Researchers analyzed the profiles of 38 gastric cancer patients and 29 healthy control patients and found that the identified fingerprints were significantly more prevalent in the cancer group.

Researchers exa


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