HOME >> MEDICINE >> NEWS
New prognostic markers help identify risk of relapse

A recently completed clinical study has found new prognostic markers that may help clinicians identify those children with leukaemia who are at high risk of relapse and are most in need of intensified treatment to improve their chance of survival.

The retrospective clinical study, performed jointly by the Centre for Children's Cancer and Blood Disorders (CCC&BD)at Sydney Children's Hospital and Children's Cancer Institute Australia, was recently published in the international Journal of Clinical Oncology. Researchers investigated how both normal and malignant blood cells of children with Acute Lymphoblastic Leukaemia (ALL) responded to the first phase of chemotherapy treatment (induction).

Dr Stephen Laughton and co-investigators found that a slow rate of recovery of normal white blood cells at the end of induction, as shown by a low absolute neutrophil count (ANC), was highly predictive of relapse.

"Many traditional predictive factors have lost their significance over time, so there is a real need to find new markers that can be used to identify high-risk patients," said A/Prof Glenn Marshall, Director of the CCC&BD and Head of the Molecular Carcinogenesis Program at CCIA.

"Our work is the first to highlight the fact that the differences in the responses of normal and malignant blood cells may vary between individuals, and, moreover, that this information might be used to adjust therapy on an individual basis."

The study also found, as investigators expected, that high levels of leukaemic cells surviving initial treatment, minimal residual disease (MRD), indicated a high risk of relapse. A technique to determine levels of MRD was pioneered at CCIA.

However, the two prognostic factors (low ANC and high MRD) were found to predict outcome by distinct mechanisms and to have independent prognostic significance.

"These results are very promising," says A/Prof Marshall. "If ANC levels can complement MRD levels at
'"/>

Contact: Susan Bogle
SBogle@ccia.org.au
61-2-9382-0047
Research Australia
28-Apr-2005


Page: 1 2

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Social support linked to prognostic marker for ovarian cancer
3. USC researchers show that molecular markers predict tumor recurrence
4. Advances in screening and markers improve early detection of colorectal cancer
5. Genetic markers in surrounding tissues linked to breast cancer tumor grade, presence of metastases
6. Scientists create dual-modality microbeads to improve identification of disease biomarkers
7. Psychosocial factors associated with higher levels of inflammatory markers
8. Newer biomarkers add small improvement in cardiovascular risk prediction to established risk factors
9. Ability of biomarkers to predict risk of heart disease, stroke appears limited
10. Measuring brain activity for emotional markers that may indicate risk for developing alcoholism
11. Biomarkers for psychosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/17/2019)... ... September 17, 2019 , ... Caravan ... care organization (ACO) in the country, the company announced today. High-performing community health ... care quality and increase cost efficiency. This opportunity is open to those new ...
(Date:9/17/2019)... ... September 17, 2019 , ... ... Warriors , with the goal of providing resources to assist researchers and encourage ... a progressive disease causing abnormal iron deposits in the brain. , BPAN ...
(Date:9/14/2019)... ... September 14, 2019 , ... GreenTheVoteOk , one of the ... again tried to bring the most relevant and important developments in the fast-changing world ... increasingly large number of people across the world suffering from different difficult-to-treat ailments, people ...
(Date:9/11/2019)... ... September 11, 2019 , ... Global Education Group (Global), a ... provider, is the official accreditor for PAINWeek, the largest US pain conference for ... as it has done for the past ten years. In addition, the Global ...
(Date:9/11/2019)... , ... September 11, 2019 , ... ... financial challenges facing specialty healthcare, announces the issuance of a patent to reduce ... integrated payment plan for both time-of-service and post visit patient statements. , At ...
Breaking Medicine News(10 mins):
(Date:9/18/2019)... ... September 18, 2019 , ... Henry Ford e-Home ... care via Henry Ford’s e-Home Care program. Achieving monthly readmission rates as low ... for the first six months of 2019 by 45% compared with the prior ...
(Date:9/18/2019)... ... September 18, 2019 , ... U.S. Dermatology Partners was ... water swim Saturday, September 14th. The event took place at Lake Ray Hubbard ... and Jim Montgomery. The money raised helps fund phase 1 clinical trials ...
(Date:9/17/2019)... ... September 17, 2019 , ... ... new, more effective therapeutic agents to stop the progressive destruction of joint cartilage ... have dawned, says Miami-based hand and upper limb orthopedic surgeon Alejandro Badia, ...
Breaking Medicine Technology:
Cached News: