New project to analyze why Polycystic Ovary Syndrome and insulin resistance are so closely linked

Understanding the link between Polycystic Ovary Syndrome (PCOS) and insulin resistance is the aim of a new project announced today, funded by the charity WellBeing of Women.

It is known that women with PCOS have a 3-fold increase in their risk of developing type-2 diabetes, where the body does not produce enough insulin or cannot use insulin properly. Insulin resistance is an important factor in the condition, which is the most common female hormone disorder. PCOS affects between 5 and 10 per cent of women and is a major cause of infertility.

The new 97K project aims to identify a defective point on the insulin signalling pathway in women with PCOS. The researchers, from Imperial College London, hope this will enable the development of new therapies which target this part of the pathway, to counter the insulin resistance and the fertility problems that PCOS can cause.

Insulin is released from cells in the pancreas after eating and it signals insulin-sensitive tissues (such as fat and muscle) to take up glucose, keeping glucose levels in the bloodstream normal. In people with insulin resistance, normal amounts of insulin are not adequate to produce a normal glucose response, meaning that levels of insulin in the bloodstream need to be higher to achieve normal blood sugar levels.

Insulin resistance (and/or the compensatory excess of insulin in the bloodstream), may contribute to abnormalities in function of the ovaries that lead to many of the symptoms of PCOS. These include irregular periods, or no periods at all; fertility problems; weight gain; acne; and excessive hair growth (hirsutism).

A longer term concern is that insulin resistance also predisposes people to diabetes. In some patients the pancreas is unable, in the long-term, to produce enough insulin to compensate for the resistance of the tissues to insulin action. Consequently, blood sugar levels rise. What is not known is why PCOS and insulin resista

Contact: Laura Gallagher
Imperial College London

Page: 1 2

Related medicine news :

1. Test project of patient-centered medical home model endorsed by American College of Physicians
2. Spanish project AmIVital creates intelligent communication devices for elderly and disabled people
3. Healthy schools project gets an A
4. Liverpool launches 20 million project to develop medicines for children
5. New family health history projects focus on Alaska Native, Appalachian communities
6. ESSP launches project on the effects of global environmental change on human health
7. Global Environmental Change and Human Health: New project launched at GEC Conference in Beijing
8. Clean water project hit by funding drought
9. $500,000 grant launches health literacy project to benefit older adults
10. St. Jude projects 90 percent cure rate for ALL
11. Virtual microscopy project wins educational technology award

Post Your Comments:
(Date:10/9/2015)... ... October 09, 2015 , ... Head Over Heels Athletic ... elite developmental camp at the Karolyi Ranch in Huntsville, Texas on October 17-21. ... Over Heels girls team head coach and executive director, said. “It's a stepping stone ...
(Date:10/9/2015)... , ... October 09, 2015 , ... On Saturday, September ... World Jump Rope Championship in Madrid, Spain. Representing both the USA and Sweden in ... Double Unders and One-Minute Am Front Crosses, she was awarded 1 Silver and 4 ...
(Date:10/9/2015)... ... October 09, 2015 , ... Confidence Plus Insurance has ... community improvement initiative that involves working with a series of local charities throughout ... Confidence Plus Insurance is the Gleason Park Electric Violin Ensemble (GPEVE). , GPEVE ...
(Date:10/9/2015)... ... October 09, 2015 , ... "As a nurse, I care for male ... "They have to wear large diapers or pads. We came up with this as ... to absorb urine leaking from the tip of the penis. This prevents stains from ...
(Date:10/9/2015)... ... October 09, 2015 , ... MMJ PhytoTech ... with Ed Begley Jr., airing 1st QT 2016 via the Discovery Channel. Dates ... MMJ Phytotech Limited (MMJ) – a global leader in the field of commercializing ...
Breaking Medicine News(10 mins):
(Date:10/9/2015)... Lilly and Company (NYSE: LLY ) and Locemia ... Locemia,s intranasal glucagon, a potential treatment for severe hypoglycemia ... which is currently in Phase III clinical trial testing, ... hypoglycemia. --> --> ... formulation that is delivered in an emergency situation using ...
(Date:10/9/2015)... CHAPEL HILL, N.C. , Oct. 9, 2015 ... Pharmaceutical or Medical Device environments, corporate communications is ... external communications, corporations and professionals must continuously adjust ... the effectiveness of these adjustments is difficult, but ... to today,s communication options. ...
(Date:10/9/2015)... Regulatory affairs groups within medical device organizations face ... --> These specialized groups are charged with ensuring that ... pertaining to the development and marketing of medical device products. ... on their own internal effectiveness and efficiencies to remain productive ... --> --> Optimal resourcing and staffing ...
Breaking Medicine Technology:
Cached News: