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New research identifies gene important for nicotine's effects on the brain

t in nerve cells involved in addictive behavior; these signaling molecules are important throughout the brain and body", says Picciotto. "The more we understand how nicotine changes the function of nerve cells, the better we will be able to neutralize its effects on behavior".

Picciotto suggests that future research focus on signaling pathways inside nerve cells and understanding which pathways are really important for nicotine addiction as opposed to other types of abuse.

Picciotto's research used both genetically engineered mice with altered nicotine receptors and viruses that could block CREB function. She and her colleagues showed that one type of nicotine receptor was important for both CREB activity and nicotine reward and that blocking CREB in the nucleus accumbens was sufficient to block nicotine reward.


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Contact: Sharon Reis
sreis@gymr.com
202-745-5103
GYMR
5-Dec-2006


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