men to 101 per 100,000 during the same time period.) Black women had a higher incidence rate of IBC--3.1 cases per 100,000 women--compared with white women (2.2 cases per 100,000 women). The authors cite heightened clinical awareness and changing patterns of risk factor exposure as possible explanations for the rise in reported cases.

Although they report that their study helps create a comprehensive definition for IBC in the SEER database, the authors state that finding a molecular determinant and genetic profile for the disease is still needed to "facilitate our understanding of the etiology of this disease, and to identify IBC subtypes that may possess common therapeutic responses and clinical outcomes," they write.

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Contact: Sarah L. Zielinski
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
5-Jul-2005

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