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New study indicates Invirase results in similar levels of viral suppression to lopinavir

The study indicates that treatment nave patients on either regime achieve similar and impressive levels of viral suppression, with nearly three quarters achieving undetectable virus at 24 weeks in the intent-to-treat analysis. Notably, the results indicate that Invirase 500/r may have the added benefit of significantly fewer patients developing elevated cholesterol and triglycerides. Elevated lipids a common side effect of several medications used to treat HIV infection, may add to the risk of developing cardiovascular disease. Now that patients are remaining on effective HIV treatment for longer, keeping a person with HIV healthy during treatment includes more than just treating the virus it is essential that other factors that impact on patient quality of life such as high cholesterol and GI adverse events are considered.

"These early results suggest that boosted Invirase has the power to control the virus in treatment nave patients, while also protecting their lipid profile," said Dr Jihad Slim, Infectious Disease Specialist, St Michael's Medical Centre and leader of the Gemini study. "If the final results show that boosted Invirase has such a good effect on viral suppression and lipids, we may see it being the preferred choice for many patients, especially those troubled by treatment side-effects."

About the Gemini study
The Gemini study is a Phase IIIb multi-centre, randomised open-label, 48 week study, designed to evaluate the efficacy and safety of Invirase 500/r versus lopinavir/r. These treatments are given at their approved twice-daily dosages in combination with two nucleoside reverse transcriptase inhibitors (NRTIs; emtricitabine/tenofovir (Truvada), once daily) in treatment nave adults. Gemini enrolled 337 patients from Canada, France, Puerto Rico, Thailand and the USA. The primary endpoint of the trial is the number of patients with an HIV-1 RNA viral load of <50 copies m/L at week 48. There are two planned interim ana
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Contact: Peter Impey
peter.impey@ketchum.com
44-797-673-4493
Ketchum
13-Nov-2006


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