HOME >> MEDICINE >> NEWS
New study shows benefit of early therapy in HIV-infected infants

Antiretroviral therapy (ART) for infants born with HIV infection may be most effective when given in their first five months of life, according to a study published in the April 1 issue of The Journal of Infectious Diseases, now available online.

Uncertainty over when to start antiretroviral treatment in children infected with HIV from their mothers revolves around balancing the benefits of preventing disease progression and the risks and costs of life-long therapy begun within months of birth. Policies on when to start ART vary across Europe. Up to this point, the effect of age on clinical outcome has been difficult to assess because CD4 cell counts--an immunological indicator of HIV progression--experience considerable age-related variation.

However, Marie-Louise Newell, MD, and her colleagues in the European Collaborative Study developed a way to standardize CD4 cell counts in relation to age, and thus better evaluate immune status. They call this age-adjusted CD4 cell count the "z-score." Based on data collected over the past 20 years on infected children born to HIV-1 infected women, the investigators concluded that "children who started their most potent ART between 5 months and 5 years of age were almost 60 percent less likely to attain a 20 percent increase in their CD4 cell count z-score at any time, compared to children who started treatment before 5 months."

However, the authors did not find an association between early age at initiation and an increased likelihood of sustaining CD4 cell level recovery. They found that the risk of subsequent deterioration was similar for children initiating treatment in all age groups.

Still, because initiating effective antiretroviral therapy before 5 months of age was strongly associated with more rapid improvement in CD4 cell count, the authors conclude it should be strongly considered in the management of infants infected with HIV.

The authors declared they had no conflicts of
'"/>

Contact: Steve Baragona
sbaragona@idsociety.org
703-299-0200
Infectious Diseases Society of America
8-Mar-2006


Page: 1 2

Related medicine news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. New study shows promise in reducing surgical risks associated with surgical bleeding
4. New study counts the economic cost of persistent pain in Australia
5. UCLA researchers awarded $9M contract for study identifiying antibiotic treatment for MRSA
6. Most seniors now have drug coverage, U-M study shows
7. To gain muscle and lose fat, drink milk: study
8. Wheres the beef? Not enough of it is on elders plates, muscle-metabolism study suggests
9. Even older women at high risk have little interest in being tested for HIV, study finds
10. Metabolic study in mice could lead to good cholesterol boosters
11. Michigan-CDC study supports value of social restrictions during influenza pandemics

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New study shows benefit early therapy HIV infected infants

(Date:3/4/2015)... Cook For Your Life (CFYL), a New ... to people touched by cancer, is launching its first ... by founder Ann Ogden, will be facilitated by Drexel ... partnership will expand the program from its base. , ... After going through her own cancer treatments, Ogden realized ...
(Date:3/4/2015)... NY (PRWEB) March 04, 2015 Smokers ... breakthrough marketing campaign called 'We Love Smokers' from Aqua-Tine, ... for tobacco. , "It’s important to establish a ... true to it. Our idea, 'We Love Smokers' elevates ... point of view. We created a bold tone of ...
(Date:3/4/2015)... (PRWEB) March 04, 2015 Blake’s ... frozen food category, will attend this year’s Natural Products ... newest product line. With this new line, Blake’s, who ... the natural channel, continues its commitment to creating high-quality ... growing frozen brand in the natural channel, Blake’s understands ...
(Date:3/4/2015)... Starting February 2015, Dr. Joseph King ... at their new location in Surrey. , In addition ... Dr. Gabriel Chu also provide comprehensive ophthalmology services, including ... Fraser Valley Cataract and Laser (FVCL). This state of ... of Physicians and Surgeons of British Columbia. Fraser Valley ...
(Date:3/4/2015)... 2015 Alliance Healthcare Foundation (AHF), a ... those in need in San Diego and Imperial Counties, ... its Mission Support Grants program with awards totaling $1 ... for AHF’s Mission Support Grants program. Grant recipients were ... trustees and program committee, as well as the community ...
Breaking Medicine News(10 mins):Health News:Drexel University and Cook for Your Life Team Up 2Health News:Drexel University and Cook for Your Life Team Up 3Health News:Drexel University and Cook for Your Life Team Up 4Health News:Drexel University and Cook for Your Life Team Up 5Health News:The Brand Behind The Bold and Provocative Ad Campaign 'We Love Smokers' 2Health News:The Brand Behind The Bold and Provocative Ad Campaign 'We Love Smokers' 3Health News:Fastest Growing Frozen Brand in Natural Channel Showcases New Line at Expo West 2015 2Health News:Fastest Growing Frozen Brand in Natural Channel Showcases New Line at Expo West 2015 3Health News:King LASIK relocates to Surrey, British Columbia 2Health News:Alliance Healthcare Foundation Awards $1 million through Mission Support Grants Program 2Health News:Alliance Healthcare Foundation Awards $1 million through Mission Support Grants Program 3
(Date:3/4/2015)... , 5. März 2015 ... Qualitätssicherung im Bereich diagnostische Röntgenstrahlung, stellte ... Radiologie, dem European Congress of Radiology ... , Österreich, einen neuen Strahlungsüberwachungssensor vor. ... http://photos.prnewswire.com/prnh/20150304/179432LOGO Der RaySafe ...
(Date:3/4/2015)... Holdings, Inc. (NYSE: HRC ) announced today ... to its Board of Directors.  She most recently served ... as President of Covidien,s Vascular Therapies Division from 2012 to ... 2012. Ms. Enxing Seng joined Covidien in ... she was a founding member and executive officer responsible ...
(Date:3/4/2015)... , March 4, 2015  Vanda Pharmaceuticals Inc. ... top-line results of the Phase II proof of ... of tradipitant as a monotherapy in the treatment ... Despite a highly significant and clinically meaningful improvement ... p<0.0001) as measured on a 100mm unit Visual ...
Breaking Medicine Technology:Unfors RaySafe, ein Unternehmen von Fluke Biomedical, stellt auf European Congress of Radiology neuen Überwachungssensor vor 2Unfors RaySafe, ein Unternehmen von Fluke Biomedical, stellt auf European Congress of Radiology neuen Überwachungssensor vor 3Hill-Rom Elects Stacy Enxing Seng to its Board of Directors 2Vanda Pharmaceuticals Announces Tradipitant Phase II Proof of Concept Study Results for Chronic Pruritus in Atopic Dermatitis 2Vanda Pharmaceuticals Announces Tradipitant Phase II Proof of Concept Study Results for Chronic Pruritus in Atopic Dermatitis 3Vanda Pharmaceuticals Announces Tradipitant Phase II Proof of Concept Study Results for Chronic Pruritus in Atopic Dermatitis 4Vanda Pharmaceuticals Announces Tradipitant Phase II Proof of Concept Study Results for Chronic Pruritus in Atopic Dermatitis 5Vanda Pharmaceuticals Announces Tradipitant Phase II Proof of Concept Study Results for Chronic Pruritus in Atopic Dermatitis 6Vanda Pharmaceuticals Announces Tradipitant Phase II Proof of Concept Study Results for Chronic Pruritus in Atopic Dermatitis 7
Cached News: