The study followed 89 boys ages seven and younger who tested positive for an abnormal gene that identifies X-ALD. Over a period of seven years, researchers treated the boys with daily oral doses of Lorenzo's Oil, a combination of two fats extracted from olive oil and rapeseed oil, and moderately restricted their dietary fat. All patients had a normal brain MRI and showed no neurological signs and symptoms of X-ALD prior to the study. At the completion of the study, nearly three-fourths (74 percent) of the 89 patients showed no signs of disease progression, demonstrating a significant preventive effect. Researchers correlated greater compliance with a lower risk of developing the disease.
"This clinical study clearly demonstrates that the use of Lorenzo's Oil can prevent the onset of the rapidly progressive and devastating form of the brain disease that affects 50 percent of boys with X-ALD," said Hugo Moser, M.D., Director of the Neurogenetics Research Center at the Kennedy Krieger Institute in Baltimore, Md., and lead author of the study. "This finding is an exciting progression of the research to which my associates and I have dedicated ourselves to help these children."
X-ALD affects 16,000 patients in the United States. The disease causes the breakdown of myelin, a fatty substance that acts as an insulator around nerve fibers. Symptoms appear between four and 10 years of ag
Contact: Colleen O'Malley
Kennedy Krieger Institute