HOME >> MEDICINE >> NEWS
New system for reporting toxicity burden of cancer treatment

A new system for reporting the relative toxicity burden of different cancer treatments is proposed in an Article published early Online and in the July edition of The Lancet Oncology.

Professor Andy Trotti, H Lee Moffitt Cancer Centre, University of South Florida, Tampa, Florida, USA and colleagues assessed deficiencies in established methods for summarising adverse events, and devised their new method.

The new system, named TAME, places traditional adverse-event data into three concise risk domains: short term toxicity (T), adverse long term effects (A) and mortality risk (M), which are calculated for each treatment programme to generate an end-result (E) summary index.

The authors say: "This is an entirely new concept in risk assessment. It was specifically designed for the evaluation of cancer treatments. Traditional safety reporting methods were designed for low-risk non-cancer treatments, and are simply overwhelmed by the amount of toxicity data generated in cancer treatment programs. Thus, a new way to look at risk that is more relevant to oncology is needed."

Despite being in the early stages of development, TAME has managed to identify differences of up to 500% in acute toxicity burden between certain cancer treatments. Established methods only detected a 170% difference in short term effects between those treatments. Established summary methods were also found to disregard a large amount of important information, and only permit comparing rates of each type of side effect (in cancer treatments there are dozens of types), whereas TAME includes all types of severe side effects, and considers their relative frequency, using a concise scoring system. However there was little difference between TAME and established methods in detecting the variation of risk in events that happened late in treatment.

TAME aims to provide a "side-effects" summary index for each treatment, so that the "total toxicity price" of
'"/>

Contact: Professor Andy Trotti
Andy.Trotti@moffitt.org
813-335-5231
Lancet
30-May-2007


Page: 1 2

Related medicine news :

1. WPI wins $1M to develop system to locate and monitor emergency workers in buildings
2. U of M researchers assess effectiveness of computerized physician order entry system
3. STAMP system can help professionals to identify potentially violent individuals
4. Doctors, engineers develop new wireless system to detect esophageal reflux
5. A pioneering system allows autistic children to communicate with their environment
6. Transplanting human gut bugs into mice helps understanding of metabolic system
7. Scientists develop method to track immune system enzyme in live animals
8. Vitamin D supplements may offer cheap and effective immune system boost against TB
9. New update of international health system comparisons: US continues to lag on most measures
10. DALYs system for measuring disability
11. Scientists equip bacteria with custom chemo-navigational system

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/2/2020)... ... September 02, 2020 , ... RAM Technologies, Inc., ... Medicare Advantage and Special Needs plans, is proud to support the 2020 National ... (AHIP). RAM is supporting the event as a sponsor and exhibitor and will ...
(Date:9/1/2020)... ... September 01, 2020 , ... Dr. Kiran Gill ... aesthetic surgery of the face, breast, and body. In 2018, she founded Aesthetics ... plastic surgery and aesthetic practice in Southwest Florida. Dr. Gill and her team ...
(Date:8/31/2020)... ... August 31, 2020 , ... Want to get moving, break up your ... Foundation (CPARF) is thrilled to launch its fourth annual STEPtember campaign in the United ... STEPtember meets everyone wherever they are at this moment — encouraging people to move ...
(Date:8/31/2020)... ... , ... A Cure for Covid-19 “PTS” with Mediation & Hypnosis , At this very ... of panic, experiencing deep anxiety, immense stress, and right now are needing serious relief from ... people on the planet are experiencing a great degree of emotional discomfort, be it fear ...
(Date:8/28/2020)... ... 28, 2020 , ... Ernst & Young LLP (EY US) ... Of The Year® 2020 Florida Award finalist. Now in its 34th year, the ... growth and prosperity as they build and sustain successful businesses that transform our ...
Breaking Medicine News(10 mins):
(Date:8/26/2020)... ... August 26, 2020 , ... ScripHessco has announced the ... infographic breaks down ways that chiropractors can help heal sports injuries and get ... “Athletes have an unusual amount of pressure and stress on their bodies, so ...
(Date:8/26/2020)... ... August 26, 2020 , ... ... announced that it has entered into definitive agreement to acquire ProCE, a ... on pharmacists and pharmacy technicians. , CEA represents a growing alliance ...
(Date:8/26/2020)... ... August 26, 2020 , ... The Lymphoma ... innovative lymphoma research and serving the lymphoma community through education programs, outreach initiatives ... LRF Gala and Charity Auction on Wednesday, Sept. 30 . The ...
Breaking Medicine Technology:
Cached News: