HOME >> MEDICINE >> NEWS
New system for reporting toxicity burden of cancer treatment

A new system for reporting the relative toxicity burden of different cancer treatments is proposed in an Article published early Online and in the July edition of The Lancet Oncology.

Professor Andy Trotti, H Lee Moffitt Cancer Centre, University of South Florida, Tampa, Florida, USA and colleagues assessed deficiencies in established methods for summarising adverse events, and devised their new method.

The new system, named TAME, places traditional adverse-event data into three concise risk domains: short term toxicity (T), adverse long term effects (A) and mortality risk (M), which are calculated for each treatment programme to generate an end-result (E) summary index.

The authors say: "This is an entirely new concept in risk assessment. It was specifically designed for the evaluation of cancer treatments. Traditional safety reporting methods were designed for low-risk non-cancer treatments, and are simply overwhelmed by the amount of toxicity data generated in cancer treatment programs. Thus, a new way to look at risk that is more relevant to oncology is needed."

Despite being in the early stages of development, TAME has managed to identify differences of up to 500% in acute toxicity burden between certain cancer treatments. Established methods only detected a 170% difference in short term effects between those treatments. Established summary methods were also found to disregard a large amount of important information, and only permit comparing rates of each type of side effect (in cancer treatments there are dozens of types), whereas TAME includes all types of severe side effects, and considers their relative frequency, using a concise scoring system. However there was little difference between TAME and established methods in detecting the variation of risk in events that happened late in treatment.

TAME aims to provide a "side-effects" summary index for each treatment, so that the "total toxicity price" of
'"/>

Contact: Professor Andy Trotti
Andy.Trotti@moffitt.org
813-335-5231
Lancet
30-May-2007


Page: 1 2

Related medicine news :

1. WPI wins $1M to develop system to locate and monitor emergency workers in buildings
2. U of M researchers assess effectiveness of computerized physician order entry system
3. STAMP system can help professionals to identify potentially violent individuals
4. Doctors, engineers develop new wireless system to detect esophageal reflux
5. A pioneering system allows autistic children to communicate with their environment
6. Transplanting human gut bugs into mice helps understanding of metabolic system
7. Scientists develop method to track immune system enzyme in live animals
8. Vitamin D supplements may offer cheap and effective immune system boost against TB
9. New update of international health system comparisons: US continues to lag on most measures
10. DALYs system for measuring disability
11. Scientists equip bacteria with custom chemo-navigational system

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/5/2018)... ... ... Headquartered in Bedford Park, Illinois, United Security Health & Casualty ’s ... Department of Health and Human Services released a new rule regarding short ... which takes effect on October 2, 2018, is increasing the maximum duration of short ...
(Date:10/5/2018)... Ill. (PRWEB) , ... October 05, 2018 , ... The ... part of the process to cross the finish line with the passage of the ... part of the FAA Reauthorization Act of 2018. The legislation provides legal protection for ...
(Date:10/5/2018)... , ... October 05, 2018 , ... From flu shots to a Halloween costume parade ... scary good variety of healthy treats for people of all ages. , The Steward Urgent ... opening celebration on Thursday, October 18. Providers at the clinic will offer flu immunizations all ...
(Date:10/3/2018)... ... October 03, 2018 , ... ... allow OB/GYNs to remotely monitor their pregnant patients’ progress and health, is now ... of Wisconsin health network (MCW). Patients who choose to use Babyscripts will get ...
(Date:10/3/2018)... ... October 03, 2018 , ... On September 7, ... mission to help children fight cancer. Co-founded by sisters-in-law Eliza Glants and Alisa ... purpose to raise awareness for children's healthcare. A portion of proceeds from each ...
Breaking Medicine News(10 mins):
(Date:10/7/2018)... ... , ... No one likes to think about an emergency, even what might seem like small ... The local ServPro professional, a trusted leader in the restoration industry, has a list of ... No time is a good time for an emergency, but having a few things in ...
(Date:10/6/2018)... ... October 06, 2018 , ... A September 17 article on ... patients. The study looked at patients’ preferences for certain foods and drinks both ... said they preferred such popular high-calorie foods as ice cream, pizza, French fries, ...
(Date:10/5/2018)... (PRWEB) , ... October 05, 2018 , ... ... announces the second call for entries for its annual “Imagine Me Beyond What ... awareness and acceptance of body images. The competition incorporates mannequins to help ...
Breaking Medicine Technology:
Cached News: