HOME >> MEDICINE >> NEWS
New test to detect rare proteins in blood

(Philadelphia, PA) Researchers at the University of Pennsylvania School of Medicine have developed a paradigm-shifting method for detecting small amounts of proteins in the blood. Applications of this method will make discerning low-abundance molecules associated with cancers (such as breast cancer), Alzheimer's disease, prion diseases, and possibly psychiatric diseases relatively easy and more accurate compared with the current methodology, including the widely used ELISA (enzyme-linked immunoadsorbent assay).

ELISA is a common immune-system-based assay that uses enzymes linked to an antibody or antigen as a marker for picking out specific proteins. For example, it is used as a diagnostic test to determine exposure to infectious agents, such as HIV, by identifying antibodies present in a blood sample.

The sensitivity of detecting molecules by the new method, called FACTT, short for Florescent Amplification Catalyzed by T7-polymerase Technique, is five orders of magnitude (100,000 times) greater than that of ELISA, the Penn researchers found.

Senior author Mark I. Greene MD, PhD, the John Eckman Professor of Medical Science, Hongtao Zhang, PhD research specialist; Xin Cheng, PhD, research investigator, and Mark Richter, a research technician in Greene's lab, report their findings in the advanced online publication of Nature Medicine.

"The current ELISA tests can only detect proteins when they are in high abundance," says Zhang. "But the problem is that many of the functional proteins those that have a role in determining your health exist in very low amounts until diseases are apparent and cannot be detected or measured at early stages of medical pathology. It was important to develop a technique that can detect these rare molecules to detect abnormalities at an early stage."

The FACTT technology uses a different enzyme amplification system so quantitative signals can be obtained from even a few protein molecules comp
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
12-Mar-2006


Page: 1 2 3 4 5

Related medicine news :

1. Method shows promise for early detection of pancreatic cancer
2. Researchers develop criteria to detect bone mass deficiencies in children with chronic diseases
3. MRI detects cancers missed by mammography in breast cancer patients
4. Doctors have key role in preventing and detecting child neglect and abuse
5. Doctors, engineers develop new wireless system to detect esophageal reflux
6. Dentists need more training in oral cancer detection
7. Personality changes may help detect form of dementia
8. Advances in screening and markers improve early detection of colorectal cancer
9. World-leading innovation in child-allergy detection
10. New accreditation program for radiation detector labs
11. MRI detects most missed opposite breast cancers in women

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/23/2020)... ... ... SignatureCare Emergency Center is set to expand to North Dallas with the opening ... heart of Lewisville, on 1596 W. Main St., Lewisville, TX 75067, the new location ... , It will serve residents and businesses around Lewisville, TX, including Double Oak, Copper ...
(Date:1/23/2020)... Okla (PRWEB) , ... January 23, 2020 , ... ... partnered with RespirCare, LLC, a first-of-its-kind, full-service pulmonology clinic based in Tulsa, to ... Under the agreement, MCNDOH patients will also have access to HGE Health’s digital ...
(Date:1/23/2020)... ... 2020 , ... Let’s face it; the holidays were a stressful time, a ... and secrets were revisited. It’s easy to understand why many folks prefer to duck ... families, the holidays posed additional stress for which there is no “cookie-cutter” solution. , ...
(Date:1/23/2020)... ... January 23, 2020 , ... Merger and acquisition activity in the Physician Medical ... according to data from HealthCareMandA.com. The total is the lowest reported in the previous ... deals were announced. , One deal disclosed a price in the fourth quarter of ...
(Date:1/23/2020)... ... January 23, 2020 , ... MemoryCare.com , a ... the Best Memory Care Facilities in Pensacola, Florida. The guide identifies 7 memory ... , According to the Alzheimer’s Association , 5.6 million people age 65 ...
Breaking Medicine News(10 mins):
(Date:1/23/2020)... ... January 23, 2020 , ... “It’s complicated.” The phrase ... architecture providing function to a person’s hand, wrist, arm and shoulder. “Which is ... surgeon -- when anything goes wrong up or down this superhighway of interconnected ...
(Date:1/22/2020)... SHIRLEY, N.Y. (PRWEB) , ... January 22, 2020 ... ... of its new Biodex Advantage BX software to U.S. customers. A total redesign ... System 4 Dynamometer with more streamlined functionality and intuitive navigation, while maintaining the ...
(Date:1/22/2020)... FRANKLIN, Tenn. (PRWEB) , ... January 22, 2020 ... ... provider of test automation solutions and technical services exclusively to the healthcare industry, ... firm to establish a comprehensive test automation program for its Epic EHR. SIH ...
Breaking Medicine Technology:
Cached News: