HOME >> MEDICINE >> NEWS
New test to detect rare proteins in blood

cate that it is possible to detect tumors at very early stages so that tumor emergence or reoccurrence can be rapidly treated or even prevented.

Greene's laboratory established many of the principles of targeted therapy for Her2/neu tumors and the prototype antibodies that led to the development of Herceptin, a similar antibody molecule that was created by Genentech. The Greene laboratory also previously showed that early treatment of Her2/neu tumors with targeted monoclonal antibodies in animal models led to far more significant prevention of tumor growth as well as tumor emergence and reoccurrence.

Greene stresses that early treatment is far more effective than treating advanced tumors with the same antibodies. Recent clinical trials support the notion that early treatment prevents tumor reoccurrence in women with breast tumors. FACTT technology represents a way to couple early diagnosis with early treatment to prevent tumor emergence.

Detecting Her2/neu in humans for breast cancer

The most widely used clinical Her2/neu tests are IHC (immunohistochemistry) and FISH (fluorescence in situ hybridization). However, both FISH and IHC are complex, time-consuming tests.

Patients who test positive for Her2/neu using FISH or IHC have responsive rates of about 35 percent to the cancer drug Herceptin. Monitoring Her2/neu status from the blood with a powerful technology such as FACTT represents an alternative approach compared to IHC or FISH, say the researchers.

Pre-treatment Her2/neu levels correlate with tumor size and the extent of disease. Post-treatment Her2/neu levels predict disease-specific survival. A more sensitive assay could more accurately allow treatment of humans with breast cancer and allow treatment more quickly if the tumor reoccurs.

The researchers collected blood samples from healthy women and breast cancer patients who did or did not overexpress Her2/neu, as detected by IHC and FISH. When
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
12-Mar-2006


Page: 1 2 3 4 5

Related medicine news :

1. Method shows promise for early detection of pancreatic cancer
2. Researchers develop criteria to detect bone mass deficiencies in children with chronic diseases
3. MRI detects cancers missed by mammography in breast cancer patients
4. Doctors have key role in preventing and detecting child neglect and abuse
5. Doctors, engineers develop new wireless system to detect esophageal reflux
6. Dentists need more training in oral cancer detection
7. Personality changes may help detect form of dementia
8. Advances in screening and markers improve early detection of colorectal cancer
9. World-leading innovation in child-allergy detection
10. New accreditation program for radiation detector labs
11. MRI detects most missed opposite breast cancers in women

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2020)... (PRWEB) , ... February 13, 2020 , ... ... seven locations in Northern Virginia: Arlington, Dulles-Aldie, Fair Oaks, Fairfax, Fredericksburg, Leesburg, and ... that eight D.C.- and Virginia-based fertility specialists have been named as Top Docs ...
(Date:2/11/2020)... ... February 11, 2020 , ... Soterius, Inc., a ... its move to a new, significantly larger business premises in Lawrenceville, NJ. The ... in the development of digital technology platforms. , “As our customer base and ...
(Date:2/10/2020)... ... February 10, 2020 , ... A January 26 article ... in certain situations. The answer is that – not unlike the skin’s response to ... and sensitivity serve as an alert to potential damage being done and warn the ...
(Date:2/10/2020)... ... 10, 2020 , ... Terry Savage , a Westat ... of the Society for Health Communication for 2020. Ms. Savage leads ... research-driven Federal social marketing campaigns and health education programs that increase knowledge, inform ...
(Date:2/10/2020)... ... February 10, 2020 , ... Rimidi , a cloud-based ... announced its founder and chief health innovator, Lucienne Ide , MD, PhD, ... . Established in 2016, the award recognizes influential women who harness the power ...
Breaking Medicine News(10 mins):
(Date:2/11/2020)... , ... February 11, 2020 , ... ... Vitamin D powdered calcium supplement, proudly announce the addition of five new products ... a healthy body. , Like FitFormula's Classic Unflavored Calcium + Vitamin D, their ...
(Date:2/10/2020)... (PRWEB) , ... February 10, 2020 , ... ... CA, is now offering EMSculpt treatments to patients. , EMSculpt is an ... approved to treat the abdomen, buttocks, thighs, calves, biceps, and triceps. The EMSculpt ...
(Date:2/10/2020)... Ky. (PRWEB) , ... February 10, 2020 , ... ... partnership with Healthstat , a leading provider of onsite health clinics. Focused ... SaaS-based population health management software, Healthward ® at its onsite employee health ...
Breaking Medicine Technology:
Cached News: