HOME >> MEDICINE >> NEWS
New 'wrinkle' in Botox treatment could lead to lower doses, better safety

There may soon be a better way to fight unsightly wrinkles. Researchers have discovered a novel way to increase the potency of botulinum neurotoxin treatments commonly known as Botox that they say could one day allow patients to receive the injections less frequently while maintaining or even enhancing its cosmetic benefits.

By allowing lower doses, the new approach could also make the treatment safer by reducing the risk of complications associated with immune system recognition that can sometimes occur with frequent injections, according to scientists at the Scripps Research Institute in La Jolla, Calif. Smaller, more potent doses may even lead to lower prices for the popular wrinkle-remover, the researchers say. Their study is published in the March 29 issue of the weekly Journal of the American Chemical Society.

Although popular for removing wrinkles, Botox is also used to treat a growing number of other conditions, including migraine headaches, lazy eyes and excessive sweating. It is developed from the botulinum neurotoxin, the most lethal poison known and a potential bioterrorist weapon. In a medical setting, small doses of a purified version of the toxin block the release of a chemical (acetylcholine) that signals muscle contraction, resulting in a localized, temporary paralysis that erases wrinkles and unwanted muscle spasms.

Kim Janda, Ph.D., a chemistry professor at Scripps and head of the research study, and his associates developed a synthetic molecule that can superactivate the neurotoxin used in Botox by binding to specific sites on the neurotoxin protein. The synthetic molecule works by increasing the activity of an enzyme that cleaves proteins that are critical for neurotransmitter release, thereby increasing the blockage of acetylcholine and enhancing the toxins paralyzing effect. In laboratory studies, the researchers found that this superactivator could boost the activity of the to
'"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-4400
American Chemical Society
5-Apr-2006


Page: 1 2

Related medicine news :

1. Botox: More than cosmetic
2. Study shows Botox decreases pain and intensity of spasticity following a stroke
3. Botox can ease writers cramp
4. Botox injections may improve facial-wound healing, minimize scars
5. Botox: Its not just for wrinkles anymore
6. Botox for more than ironing wrinkles
7. Botox injections effective for treating stroke spasticity
8. Botox stops severe drooling in children with neurologic conditions
9. Spot on treatment for acne
10. New treatment boosts muscle function in myasthenia gravis
11. New treatment effective in counteracting cocaine-induced symptoms

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. ... The attorneys chosen by their peers for this recognition are considered among the top ... Shareholders received special honors as members of this year’s Legal Elite Hall of Fame: ...
(Date:6/24/2016)... ... 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited to ... Recovery® program to drive cancer patients to and from their cancer treatments. Comfort ... quality of life and ongoing independence. Getting to and from medical treatments is ...
(Date:6/24/2016)... , ... June 24, 2016 , ... People across the ... Genome magazine’s Code Talker Award, an essay contest in which patients and their families ... to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... is proud to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon ... beautiful women in the world, and the most handsome men, look naturally attractive. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic Capital Partners, LLC (SCP) ... obtaining investment capital for emerging technology companies. SCP has delivered investment events ... in more than a million dollars of capital investment for five companies. ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 26, 2016 One of Australia,s ... announced the formation of a new biotechnology company, Noxopharm Limited [ABN ... in an IPO and to list on the ASX. ... NOX66, ready to enter a Phase 1 clinical study later this ... to address one of the biggest problems facing cancer patients - ...
(Date:6/26/2016)... , June 27, 2016 Jazz Pharmaceuticals plc ... period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976, ... of Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: CPXX ... (Eastern Daylight Time). As previously announced on ... a definitive merger agreement under which Jazz Pharmaceuticals has ...
(Date:6/26/2016)... Ontario , June 27, 2016  VMS Rehab ... Company,s Board will take whatever measures required to build ... Company,s stock which is currently listed on the OTC ... Wexler, Company Chairman and CEO, "We are seeing an ... difficult to understand, not only by the Company, but ...
Breaking Medicine Technology:
Cached News: