Newer chemotherapies improve outcomes for some types of breast cancer

CHICAGO An updated analysis of findings from three major consecutive clinical trials of breast cancer treatment conducted over the past twenty years indicates that women who have breast cancer with lymph node involvement and estrogen-receptor negative tumors have a lower rate of recurrence and risk of death with treatment with newer chemotherapies, according to a study in the April 12 issue of JAMA.

Breast cancer estrogen-receptor status (ER how cells respond to specific hormonal therapies) helps identify patients who benefit from endocrine therapy. With appropriate endocrine therapy, patients with ERpositive disease have substantially better prognoses as a group than do those with ERnegative disease. Evidence is accumulating that improvements in chemotherapy disproportionately benefit patients with ERnegative tumors.

Donald A. Berry, Ph.D., of the University of Texas M. D. Anderson Cancer Center, Houston, and colleagues examined whether breast cancer patients who have lymph node involvement and ERnegative tumors benefit more from recent improvements in supplemental chemotherapy than do women with ERpositive tumors treated with tamoxifen. The researchers compared disease-free and overall survival according to ER status among 6,644 patients enrolled in three consecutive randomized trials of chemotherapy conducted by the Cancer and Leukemia Group B and the U.S. Breast Cancer Intergroup. The trials compared (1): three regimens of cyclophosphamide, doxorubicin, and fluorouracil (January 1985 to April 1991); (2) three doses of doxorubicin concurrent with cyclophosphamide, with or without subsequent paclitaxel (May 1994 to April 1997); (3) sequential doxorubicin, paclitaxel, and cyclophosphamide with concurrent doxorubicin and cyclophosphamide followed by paclitaxel, and also three-week vs. two-week cycles (September 1997 to March 1999).

The researchers found that for ERnegative tumors, chemotherapy improvements reduced the relative risk of re

Contact: Nancy Jensen
JAMA and Archives Journals

Page: 1 2 3

Related medicine news :

1. Newer biomarkers add small improvement in cardiovascular risk prediction to established risk factors
2. Newer form of cardiac imaging providing better look at heart
3. Newer diabetic meds cost more, but users have fewer hospital visits
4. Newer imaging techniques may lead to over-treatment
5. Early-childhood intervention may improve well-being through young adulthood
6. U of M report says early-childhood intervention improves well-being through young adulthood
7. Health reform bills could improve quality and efficiency, but fall short of national plan
8. Program announced to improve care in developing areas for patients with blood disorders
9. LSUHSC awarded designation resulting in improved patient safety and outcomes
10. When minority patients have insurance and a medical home, their health care improves
11. A new direction: Integrating best-practices to improve food responses

Post Your Comments:

(Date:10/13/2017)... ... , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has ... least understood books in the Holy Scriptures, Revelation. The Book of Revelation paints a ... centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins says that ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian history of ... Brink” is the creation of published author, William Nowers. Captain Nowers and his ... veteran, he spent thirty years in the Navy. Following his career as a ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has ... today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every formula ... the highest standard. , These products are also: Gluten Free, Non-GMO, Vegan, ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about the technology: ... develop to enable prevention of a major side effect of chemotherapy in children. ... pediatric patients. For cisplatin, hearing loss is FDA listed on-label as a dose ...
(Date:10/12/2017)... ... October 12, 2017 , ... On Saturday, October 21, ... relay – Miles by Moonlight to raise money for the American Heart Association Heart ... , Teams will work together to keep their treadmills moving for 5 hours. ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... West Pharmaceutical Services, Inc. (NYSE: ... drug administration, today announced that it will release third-quarter ... October 26, 2017, and will follow with a conference ... 9:00 a.m. Eastern Time. To participate on the call, ... ID is 94093362. ...
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 2017  According to the Centers for Disease Control and Prevention (CDC), ... PhysicianOne Urgent Care is helping communities across Massachusetts , ... by offering no-cost* flu shots through the end of the month. ... insurance regulations. ... get a flu shot is by the end of October, according to ...
Breaking Medicine Technology:
Cached News: