HOME >> MEDICINE >> NEWS
Newly discovered behavior in cancer cells signals dangerous metastasis

DURHAM, N.C. -- The most aggressively malignant cancer cells have a "toggle switch" that enables them to morph into highly mobile cells that invade other tissues and then nest comfortably in their new surroundings, a new study in rats suggests.

This picture of how cancer cells shift between two alternating states -- travelers and nesters -- represents a new understanding of how cancer metastasizes, or spreads to other parts of the body, said the Duke Comprehensive Cancer Center researchers who conducted the study.

"Understanding this toggle switch might ultimately enable scientists to find ways to stop cells from metastasizing, which is the most deadly trait of cancer," said the study's lead investigator, Mariano Garcia-Blanco, M.D., Ph.D., professor of molecular genetics and microbiology.

The researchers will publish their findings in the Sept. 19, 2006, issue of the journal Proceedings of the National Academy of Sciences, now available on line. The research was funded by the National Cancer Institute.

Until now, scientists have believed that cancer cells must transform permanently from stationary epithelial cells into migratory mesenchymal cells in order to metastasize.

The Duke team discovered that highly malignant cells are equal parts epithelial and mesenchymal, transitioning between the two as their surroundings necessitate. The proteins that the cell produces dictate which way the cell shifts.

In a classic example of survival of the fittest, a cancer cell's ability to toggle between epithelial and mesenchymal enables the most malignant cells to aggressively invade and then peacefully adapt in unfamiliar territory, the scientists said.

"The prevailing notion has been that the more mesenchymal the cancer cells, the more mobile and metastatic they would be," Garcia-Blanco said. "In reality, aggressive cancer cells are not homogenous, but are extremely versatile in their ability to adapt as their s
'"/>

Contact: Rebecca Levine
Levin005@mc.duke.edu
919-684-4148
Duke University Medical Center
15-Sep-2006


Page: 1 2 3

Related medicine news :

1. Newly discovered killer cell fights cancer
2. Newly discovered gene may predict aggressive ovarian cancer
3. Newly published summer camp health guideline advises parents, camp directors
4. Newly developed treatment for severe grief shown more effective than standard therapy
5. Newly discovered branding process helps immune system cells pick their fights
6. New cause of tamoxifen resistance in breast cancer cells discovered at Lombardi
7. Mechanism of hallucinogens effects discovered
8. New dopamine brain target discovered
9. Treatment discovered for deadly childhood disease
10. New study finds no link between Kawasaki disease and newly discovered coronavirus
11. Emotional control circuit of brains fear response discovered

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... ... , ... Just found out your dear friend has cancer? , It’s hard to hear your ... shares their diagnosis. Once the shock wears off, the questions and fears can be overwhelming. ... best ways to help? Words are failing me. I’m scared. I want to DO something. ...
(Date:8/31/2020)... ... August 31, 2020 , ... Colorado State University Global (CSU ... affordable online education – is proud to announce its new master’s degree in ... its kind in the nation, the 60-credit hour program is designed to provide ...
(Date:8/31/2020)... ... August 31, 2020 , ... In an effort to give back to ... 10 percent of each hotel room booked with a special new rate code to ... Indiana (RMHC-CNI) , effective immediately. Donations will be applied to any room type, ...
(Date:8/28/2020)... ... 28, 2020 , ... Ernst & Young LLP (EY US) ... Of The Year® 2020 Florida Award finalist. Now in its 34th year, the ... growth and prosperity as they build and sustain successful businesses that transform our ...
(Date:8/28/2020)... (PRWEB) , ... August 28, 2020 , ... Integrated ... Miami is the first Florida school to deploy its breakthrough Mobile Biodefense Indoor Air ... airborne COVID-19. True North Classical Academy plans to fully reopen equipped with the filtration ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... While coronavirus cases continue to increase across ... and community organizations remain closed. Because about 80% of blood donations are made at ... blood donors and blood drive hosts to ensure blood products are readily available for ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... If you live in New York City ... real estate part makes sense, it’s the law of supply and demand, but are plastic ... has a significant percentage of their patients that make the four-hour trip to have ...
(Date:8/28/2020)... (PRWEB) , ... August 28, 2020 , ... Dr. ... reproductive and endoscopic surgeon and serves as a clinical professor in the Department of ... of the American Laparoscopy Society & Pacific Coast Reproductive Society and is a Clinical ...
Breaking Medicine Technology:
Cached News: