HOME >> MEDICINE >> NEWS
Newly discovered killer cell fights cancer

A mouse immune cell that plays dual roles as both assassin and messenger, normally the job of two separate cells, has been discovered by an international team of researchers from the United States and France. The discovery has triggered a race among scientists to find a human equivalent of the multitasking cell, which could one day be a target for therapies that seek out and destroy cancer.

"In the same way that intelligence and law enforcement agencies can face deadly threats together instead of separately, this one cell combines the ability to kill foreign pathogens and distribute information about that experience," says Drew Pardoll, M.D., Ph.D., the Seraph Professor of Oncology at the Johns Hopkins Kimmel Cancer Center.

"We think this hybrid cell speeds up immune reactions and makes the system more efficient," adds Pardoll, whose findings are reported in the February issue of Nature Medicine.

The Hopkins investigators speculate that the hybrid, dubbed "IKDC" for interferon-producing killer dendritic cell, has been missed by cancer biologists because it is rare, making up one-tenth of cells in the spleen with similar features, such as other dendritic cells, according to Frank Housseau, Ph.D., research associate at Hopkins' Kimmel Cancer Center and member of Pardoll's immunology laboratory.

Most of the immune system typically works through a web of cross-talk and signaling among a variety of cells. One of the first immune cells that invading bacteria or cancer cells - both of which carry antigens that alert the immune system - may encounter is a natural killer (NK) cell. As its name implies, NK cells deliver a deadly blow by poking holes in the invader's outer membrane. Then, NK cells secrete molecules that reach other immune cells, including dendritic cells, known as the main messenger for the immune system. Dendritic cells spread "look here" information about foreign invaders to other immune cells, but do not actually kill
'"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
3-Mar-2006


Page: 1 2 3

Related medicine news :

1. Newly discovered behavior in cancer cells signals dangerous metastasis
2. Newly discovered gene may predict aggressive ovarian cancer
3. Newly published summer camp health guideline advises parents, camp directors
4. Newly developed treatment for severe grief shown more effective than standard therapy
5. Newly discovered branding process helps immune system cells pick their fights
6. New cause of tamoxifen resistance in breast cancer cells discovered at Lombardi
7. Mechanism of hallucinogens effects discovered
8. New dopamine brain target discovered
9. Treatment discovered for deadly childhood disease
10. New study finds no link between Kawasaki disease and newly discovered coronavirus
11. Emotional control circuit of brains fear response discovered

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/3/2020)... ... September 03, 2020 , ... BluePearl Specialty and ... Suicide Prevention’s (AFSP) annual signature event, Out of the Darkness (OOTD), which unites ... to raise awareness of suicide prevention. To ensure Associate safety, BluePearl will not ...
(Date:9/2/2020)... ... September 02, 2020 , ... ... for healthcare payers administering Medicare Advantage and Special Needs plans, is proud to ... America’s Health Insurance Plans (AHIP). RAM is supporting the event as a sponsor ...
(Date:9/1/2020)... ... September 01, 2020 , ... Dr. Kiran ... in aesthetic surgery of the face, breast, and body. In 2018, she founded ... boutique plastic surgery and aesthetic practice in Southwest Florida. Dr. Gill and her ...
(Date:8/31/2020)... ... ... Want to get moving, break up your routine, and make a difference ... launch its fourth annual STEPtember campaign in the United States to raise funds and ... are at this moment — encouraging people to move in the ways that work ...
(Date:8/31/2020)... ... ... Cure for Covid-19 “PTS” with Mediation & Hypnosis , At this very turbulent time ... experiencing deep anxiety, immense stress, and right now are needing serious relief from a constant ... the planet are experiencing a great degree of emotional discomfort, be it fear or worrying ...
Breaking Medicine News(10 mins):
(Date:8/27/2020)... Calif. (PRWEB) , ... August 27, 2020 , ... ... the conclusion of its fundraising initiative for Feeding San Diego with a ... What: The GHT Companies presents the final check of $5,000.00+ representing an overall donation ...
(Date:8/26/2020)... ... 26, 2020 , ... AseptiScope, a privately funded San Diego, California based, clinical ... MedTech Outlook. , “AseptiScope is pleased to receive this recognition,” said Kelly ... gloves on their hands, goggles on their eyes, covers on their shoes, and gowns ...
(Date:8/26/2020)... , ... August 26, 2020 , ... ... in-home air purification systems kill Coronavirus. While air purification technologies, including GreenTech Environmental’s ... SARS and even Ebola, no air purification system has published results of singular ...
Breaking Medicine Technology:
Cached News: