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glutamate acting as an electrostatic mimic for phosphorylated residues. Using Sindbis virus, the authors expressed wild-type and PHP tau in mouse hippocampal slices. Three days later, extracellular lactate dehydrogenase, an indicator of membrane damage, was greatly increased in the PHP slices, as was caspase-3 activity and DNA fragmentation, suggestive of apoptotic cell death. However, some cells showed swollen cell bodies, not consistent with purely apoptotic cell death. Taumediated death was concentrated in CA3 and the dentate gyrus. Spine density and morphology were remarkably stable in the presence of PHP tau.


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Contact: Tracey Somers
tsomers@sfn.org
202-962-4000
Society for Neuroscience
30-May-2006


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