STUDY SHOWS LUNG CANCER MAY BE HEREDITARY

People who have a family history of lung cancer are at nearly double the risk of developing the disease themselves, according to new research. In a large-scale, population-based cohort, Japanese researchers studied the association between family history of lung cancer and subsequent risk. Self-administered surveys on various lifestyle factors were administered to 102,255 middle-aged and older Japanese subjects at baseline (1990 for Cohort I and 1993-94 for Cohort II), with a 13-year follow-up. Smoking habits were classified as current, former, and never. Researchers found that those subjects who had a history of having a first-degree relative with lung cancer had a nearly twofold the risk of developing lung cancer. The association was also stronger in women than in men, and never-smokers versus current smokers. In addition, family history of lung cancer was more strongly associated with the risk of other types of cancers. However, a family history of overall cancer was not associated with an increased risk of lung cancer. This study appears in the October issue of CHEST, the peer-reviewed journal of the American College of Chest Physicians.

COPD PATIENTS WITH ACID REFLUX ARE TWICE AS LIKELY TO EXPERIENCE EXACERBATIONS

A new study shows an association between acid reflux symptoms and chronic obstructive pulmonary disease (COPD) exacerbations. Using a questionnaire-based, cross-sectional survey, researchers from the University of Florida, Jacksonville, investigated the prevalence and effect of acid reflux symptoms, formally known as gastroesophageal reflux disease (GERD), on the rate of exacerbations in 86 patients with COPD (57 percent men, mean age 67.5 years). Patients were recruited from outpatient pulmonary and general medicine clinics, and all completed the Mayo Clinic GERD questionnaire. Researchers defined clinically significant reflux as heartburn and/or acid regurgitation weekly, a
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Contact: Deana Busche
dbusche@chestnet.org
847-498-8387
American College of Chest Physicians
9-Oct-2006