HOME >> MEDICINE >> NEWS
No improvement in overall survival with lymph node removal in treatment of advanced ovarian cancer

Removing the aortic and pelvic lymph nodes during surgery for advanced ovarian cancer improves progression-free survival but not overall survival, according to a new study in the April 20 issue of the Journal of the National Cancer Institute.

Ovarian cancer is the fifth most common cancer in women worldwide. In the United States, about 25,000 women were diagnosed with the disease in 2004 and 16,000 women died from it. Long-term survival is possible after surgery and chemotherapy, but only about 30% of patients with advanced ovarian cancer survive 5 or more years after diagnosis. Retrospective studies have suggested that lymphadenectomy--the removal of the aortic and pelvic lymph nodes during cytoreductive surgery to remove the cancer--may improve survival, but the value of the procedure remains controversial.

To determine whether systematic aortic and pelvic lymphadenectomy improves progression-free and overall survival, Pierluigi Benedetti Panici, M.D., of "La Sapienza" University in Rome, and colleagues conducted a clinical trial in which 427 patients with advanced ovarian cancer were randomly assigned to undergo either primary cytoreductive surgery followed by lymphadenectomy or cytoreductive surgery only. The patients were followed for an average of 68.4 months.

The 5-year progression-free survival rate was greater among patients treated with lymphadenectomy (31.2%) than among those who had only enlarged nodes removed (21.6%), and the duration of progression-free survival was also longer in the lymphadenectomy group (29.4 months versus 22.4 months). However, the 5-year overall survival rate and the median overall survival duration were similar in both groups. In addition, compared with the group that did not have lymphadenectomy, women who were treated with lymphadenectomy had a longer operating time, and more of these women required blood transfusions.

"This study found that 1) the addition of systematic lymphadenectomy t
'"/>

Contact: Sarah L. Zielinski
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
19-Apr-2005


Page: 1 2

Related medicine news :

1. Borderline personality disorder shows improvements with intensive psychotherapy
2. Quality improvement effort pays off in diabetes care
3. Implanting dopamine generators in brain cells obtains improvement in Parkinsons in monkeys
4. Exercise may lead to improvement in patients with Parkinsons
5. Home improvement warning -- Ladder-related injuries increasing in the US
6. Acute coronary syndrome therapy improvements linked with fewer deaths and improved clinical outcomes
7. Fiber-based light source promises improvements in food inspection
8. Chronic disease management quality improvement efforts yield better care delivery
9. Newer biomarkers add small improvement in cardiovascular risk prediction to established risk factors
10. New research shows big improvement in survival after stroke
11. Enbrel provides sustained clinical improvements for ankylosing spondylitis for up to 3 years

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2017)... Dayton, NJ (PRWEB) , ... May 26, 2017 , ... ... in Fort Lee, New Jersey School District had left education officials with a number ... removal and replacement of the flooring had to be accomplished with little or no ...
(Date:5/24/2017)... ... May 24, 2017 , ... Altec Products, Inc., a leader in ... a one-day technology conference in San Diego, CA. , At nVerge 2017, Altec ... fully utilize and enhance their Sage ERP solutions by providing improved visibility and control ...
(Date:5/24/2017)... Cortland, OH (PRWEB) , ... May 24, 2017 , ... ... in Cortland, OH, can now meet with Dr. Joseph Bedich for a consultation, ... smiles while simultaneously improving their oral health and functionality. , Dr. Bedich ...
(Date:5/24/2017)... Clarkston, Lake Orion, Michigan (PRWEB) , ... ... ... Endometriosis is a disease affecting the female reproductive tract in which the ... on the pelvic structures causing inflammation and pain. Patients experiencing painful intercourse, ...
(Date:5/24/2017)... ... May 24, 2017 , ... ... offering holistic pediatric dentistry options for its patients on Long Island, New York. ... entire physical well being, and is one of the biggest trends in dentistry ...
Breaking Medicine News(10 mins):
(Date:5/22/2017)... May 22, 2017  Lilac Corp, the company ... the launch of a new website . ... of a clinical study that showed surprising clearance ... Gene-Eden-VIR/Novirin in individuals suffering from HPV warts, precancerous, ... there are no other treatments that clear the ...
(Date:5/18/2017)... May 18, 2017  Two Bayer U.S. Pharmaceutical leaders ... during its recent 28 th Woman of ... event showcases HBA,s longstanding mission of furthering the advancement ... Cindy Powell-Steffen , senior director of ... division, and Libby Howe , a regional business ...
(Date:5/15/2017)... 2017  Amy Baxter MD, chief executive officer and ... pain relief, was awarded a 2017 Top 40 Healthcare ... recognized at the MM&M Top 40 Healthcare Transformers dinner ... on May 10, 2017. The dinner followed a ... "beyond the pill."  "Innovation goes beyond invention," ...
Breaking Medicine Technology:
Cached News: