HOME >> MEDICINE >> NEWS
No improvement in overall survival with lymph node removal in treatment of advanced ovarian cancer

Removing the aortic and pelvic lymph nodes during surgery for advanced ovarian cancer improves progression-free survival but not overall survival, according to a new study in the April 20 issue of the Journal of the National Cancer Institute.

Ovarian cancer is the fifth most common cancer in women worldwide. In the United States, about 25,000 women were diagnosed with the disease in 2004 and 16,000 women died from it. Long-term survival is possible after surgery and chemotherapy, but only about 30% of patients with advanced ovarian cancer survive 5 or more years after diagnosis. Retrospective studies have suggested that lymphadenectomy--the removal of the aortic and pelvic lymph nodes during cytoreductive surgery to remove the cancer--may improve survival, but the value of the procedure remains controversial.

To determine whether systematic aortic and pelvic lymphadenectomy improves progression-free and overall survival, Pierluigi Benedetti Panici, M.D., of "La Sapienza" University in Rome, and colleagues conducted a clinical trial in which 427 patients with advanced ovarian cancer were randomly assigned to undergo either primary cytoreductive surgery followed by lymphadenectomy or cytoreductive surgery only. The patients were followed for an average of 68.4 months.

The 5-year progression-free survival rate was greater among patients treated with lymphadenectomy (31.2%) than among those who had only enlarged nodes removed (21.6%), and the duration of progression-free survival was also longer in the lymphadenectomy group (29.4 months versus 22.4 months). However, the 5-year overall survival rate and the median overall survival duration were similar in both groups. In addition, compared with the group that did not have lymphadenectomy, women who were treated with lymphadenectomy had a longer operating time, and more of these women required blood transfusions.

"This study found that 1) the addition of systematic lymphadenectomy t
'"/>

Contact: Sarah L. Zielinski
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
19-Apr-2005


Page: 1 2

Related medicine news :

1. Borderline personality disorder shows improvements with intensive psychotherapy
2. Quality improvement effort pays off in diabetes care
3. Implanting dopamine generators in brain cells obtains improvement in Parkinsons in monkeys
4. Exercise may lead to improvement in patients with Parkinsons
5. Home improvement warning -- Ladder-related injuries increasing in the US
6. Acute coronary syndrome therapy improvements linked with fewer deaths and improved clinical outcomes
7. Fiber-based light source promises improvements in food inspection
8. Chronic disease management quality improvement efforts yield better care delivery
9. Newer biomarkers add small improvement in cardiovascular risk prediction to established risk factors
10. New research shows big improvement in survival after stroke
11. Enbrel provides sustained clinical improvements for ankylosing spondylitis for up to 3 years

Post Your Comments:
(Date:8/29/2015)... PA (PRWEB) , ... August 29, 2015 , ... ... due to insufficient scrotal support and protection against dribbled urine and sweat. "In ... from Manhasset Hills, N.Y. , The EASY ACCESS DRYNESS ENHANCED MEN'S UNDERGARMENT provides ...
(Date:8/29/2015)... ... ... Next weekend is Labor Day weekend, the last bash of the season ... year). For IT security personnel, it should also mark the perfect time to make ... than a simple headache. , Joe Caruso, founder and CEO-CTO of Global Digital ...
(Date:8/29/2015)... ... , ... The popular television program VOICES IN AMERICA, hosted by legendary star ... devoting an entire short segment to the subject of diabetes. Diabetes is a debilitating ... daily basis, but recent advancements in medical science may prove to be a significant ...
(Date:8/28/2015)... ... August 28, 2015 , ... An online provider of CPAP ... the purchase of CPAP equipment more affordable by offering shipping at no cost to ... CPAP products and orders of any size. My Cpap Store is located in Las ...
(Date:8/28/2015)... ... August 28, 2015 , ... With the goal of furthering music education ... year to the Adams County Fairgrounds in Mendon, IL on May 30th, 2015. Backed ... support music education in the underfunded school districts of Mendon and its neighboring town ...
Breaking Medicine News(10 mins):Health News:Modified Men’s Underwear Promote More Comfort and Hygiene - Designed by InventHelp Client (LGI-1968) 2Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 2Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 3Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 4Health News:My Cpap Store Now Offering Delivery Special 0 Cost to You 2Health News:Best Drug Rehabilitation Interviews Country-Rock Duo Highway Run at the 2015 "Music With A Mission" Benefit Concert 2
(Date:8/28/2015)... WARRENVILLE, Ill. , Aug. 28, 2015 /PRNewswire/ ... Patterson Companies, Inc. (Nasdaq: PDCO ), is ... the previously announced acquisition of Patterson Medical by ... Medical will retain its name for a transition ... distributor of rehabilitation and sports medicine products.  With ...
(Date:8/28/2015)... The scientific team of a new ... the leading academics in the field of aging Prof. ... life extension for model animals - 10 fold for nematodes) ... age-related diseases, primarily, around the stability and stress resistance of ... as "Stability analysis of a model gene network links aging, ...
(Date:8/28/2015)... England and PITTSBURGH ... MYL ) today announced that its shareholders ... plc (NYSE: PRGO ; TASE) and the ... shareholders at an extraordinary general meeting of shareholders ... the votes cast at the extraordinary general meeting. ...
Breaking Medicine Technology:Patterson Medical Positioned for Continued Growth as a Newly Independent Company 2Patterson Medical Positioned for Continued Growth as a Newly Independent Company 3Gero: Physics Meets Biology to Help Defeat Aging 2Gero: Physics Meets Biology to Help Defeat Aging 3Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 2Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 3Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 4Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 5Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 6Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 7Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 8Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 9
Cached News: