HOME >> MEDICINE >> NEWS
No improvement in overall survival with lymph node removal in treatment of advanced ovarian cancer

Removing the aortic and pelvic lymph nodes during surgery for advanced ovarian cancer improves progression-free survival but not overall survival, according to a new study in the April 20 issue of the Journal of the National Cancer Institute.

Ovarian cancer is the fifth most common cancer in women worldwide. In the United States, about 25,000 women were diagnosed with the disease in 2004 and 16,000 women died from it. Long-term survival is possible after surgery and chemotherapy, but only about 30% of patients with advanced ovarian cancer survive 5 or more years after diagnosis. Retrospective studies have suggested that lymphadenectomy--the removal of the aortic and pelvic lymph nodes during cytoreductive surgery to remove the cancer--may improve survival, but the value of the procedure remains controversial.

To determine whether systematic aortic and pelvic lymphadenectomy improves progression-free and overall survival, Pierluigi Benedetti Panici, M.D., of "La Sapienza" University in Rome, and colleagues conducted a clinical trial in which 427 patients with advanced ovarian cancer were randomly assigned to undergo either primary cytoreductive surgery followed by lymphadenectomy or cytoreductive surgery only. The patients were followed for an average of 68.4 months.

The 5-year progression-free survival rate was greater among patients treated with lymphadenectomy (31.2%) than among those who had only enlarged nodes removed (21.6%), and the duration of progression-free survival was also longer in the lymphadenectomy group (29.4 months versus 22.4 months). However, the 5-year overall survival rate and the median overall survival duration were similar in both groups. In addition, compared with the group that did not have lymphadenectomy, women who were treated with lymphadenectomy had a longer operating time, and more of these women required blood transfusions.

"This study found that 1) the addition of systematic lymphadenectomy t
'"/>

Contact: Sarah L. Zielinski
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
19-Apr-2005


Page: 1 2

Related medicine news :

1. Borderline personality disorder shows improvements with intensive psychotherapy
2. Quality improvement effort pays off in diabetes care
3. Implanting dopamine generators in brain cells obtains improvement in Parkinsons in monkeys
4. Exercise may lead to improvement in patients with Parkinsons
5. Home improvement warning -- Ladder-related injuries increasing in the US
6. Acute coronary syndrome therapy improvements linked with fewer deaths and improved clinical outcomes
7. Fiber-based light source promises improvements in food inspection
8. Chronic disease management quality improvement efforts yield better care delivery
9. Newer biomarkers add small improvement in cardiovascular risk prediction to established risk factors
10. New research shows big improvement in survival after stroke
11. Enbrel provides sustained clinical improvements for ankylosing spondylitis for up to 3 years

Post Your Comments:
(Date:7/29/2014)... new lung is grown for a patient in need, using ... injection of replacement cells will enable a patient to self-heal ... ALERT: For audio and video of Dr. Keller and Jorge ... Mayo Clinic News Network . , Regenerative ... gift from Jorge and Leslie Bacardi of the Bahamas will ...
(Date:7/29/2014)... Dallas, Texas (PRWEB) July 29, 2014 ... the Global Biosimilars Market report is an essential ... biosimilars industry. Using detailed company data, financial analysis, ... in-depth analysis of the current and future growth ... the various regulatory frameworks under which biosimilars are ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 The Affordable ... reimbursement model of all hospitals. Studies show that over ... One simple, easy, low cost tool that great hospitals ... by 20 to 25%. , Their secret? Debriefing - ... anther at the end of an operational event. Debriefing ...
(Date:7/29/2014)... day lead to a more streamlined process for obtaining stem ... of replacement tissue for failing body parts, according to UC ... edition of Cell . , The work builds on ... embryonic state in which they again have the potential to ... this process may soon increase thanks to the scientists, identification ...
(Date:7/29/2014)... Little Rock, AR (PRWEB) July 29, 2014 ... S.Res.518 , a resolution declaring the week of October ... the value of case management in improving healthcare outcomes ... Pryor (D-AR) and Senator John Boozman (R-AR), with support ... American Case Management Association to honor case management professionals ...
Breaking Medicine News(10 mins):Health News:Bacardis make gift to significantly advance Mayo Clinic's regenerative medicine research 2Health News:Bacardis make gift to significantly advance Mayo Clinic's regenerative medicine research 3Health News:Bacardis make gift to significantly advance Mayo Clinic's regenerative medicine research 4Health News:World Biosimilars Market Value Exceed $262 Billion by 2019 Says a New Report Available at MarketOptimizer.org 2Health News:World Biosimilars Market Value Exceed $262 Billion by 2019 Says a New Report Available at MarketOptimizer.org 3Health News:World Biosimilars Market Value Exceed $262 Billion by 2019 Says a New Report Available at MarketOptimizer.org 4Health News:One Brilliant Economic Survival Tool You Can Steal from the World's Best Hospitals 2Health News:One Brilliant Economic Survival Tool You Can Steal from the World's Best Hospitals 3Health News:Stem cell advance may increase efficiency of tissue regeneration 2Health News:Stem cell advance may increase efficiency of tissue regeneration 3Health News:CMSA Supports National Case Management Week Resolution Introduced in US Senate 2
(Date:7/29/2014)... Cynosure, Inc. (Nasdaq: CYNO ), which ... for high-volume applications, today reported financial results for the ... results incorporate the acquisition of Palomar Medical Technologies, which ... Second-Quarter 2014 Financial Highlights , ... Non-GAAP net income of $7.1 million, or $0.32 per ...
(Date:7/29/2014)... --   What:   AFFiRiS AG, ... from a Phase I clinical trial of PD01A, a ... disease progression. The Michael J. Fox Foundation supported the ... the impact of the results for patients and the ... 2014         11.00 am ...
(Date:7/29/2014)... VIEW, Calif. , July 29, 2014 /PRNewswire/ ... has amplified with rising incidence rates and the ... of a preventative vaccine. Change is underway as ... interferon regimens towards highly effective, easily-tolerated, interferon-free oral ... Gilead,s mega blockbuster Sovaldi ...
Breaking Medicine Technology:Cynosure Reports Second-Quarter 2014 Financial Results 2Cynosure Reports Second-Quarter 2014 Financial Results 3Cynosure Reports Second-Quarter 2014 Financial Results 4Cynosure Reports Second-Quarter 2014 Financial Results 5Cynosure Reports Second-Quarter 2014 Financial Results 6Cynosure Reports Second-Quarter 2014 Financial Results 7Cynosure Reports Second-Quarter 2014 Financial Results 8Cynosure Reports Second-Quarter 2014 Financial Results 9Cynosure Reports Second-Quarter 2014 Financial Results 10Cynosure Reports Second-Quarter 2014 Financial Results 11Cynosure Reports Second-Quarter 2014 Financial Results 12Reminder/Media Advisory/AFFiRiS AG Presents Early Clinical Data on a First-of-its-Kind Parkinson's Disease Vaccine 2A Treatment Revolution is Underway: All-Oral Therapies Transform Global Hepatitis C Antiviral Market 2A Treatment Revolution is Underway: All-Oral Therapies Transform Global Hepatitis C Antiviral Market 3A Treatment Revolution is Underway: All-Oral Therapies Transform Global Hepatitis C Antiviral Market 4
Cached News: