HOME >> MEDICINE >> NEWS
No improvement in overall survival with lymph node removal in treatment of advanced ovarian cancer

Removing the aortic and pelvic lymph nodes during surgery for advanced ovarian cancer improves progression-free survival but not overall survival, according to a new study in the April 20 issue of the Journal of the National Cancer Institute.

Ovarian cancer is the fifth most common cancer in women worldwide. In the United States, about 25,000 women were diagnosed with the disease in 2004 and 16,000 women died from it. Long-term survival is possible after surgery and chemotherapy, but only about 30% of patients with advanced ovarian cancer survive 5 or more years after diagnosis. Retrospective studies have suggested that lymphadenectomy--the removal of the aortic and pelvic lymph nodes during cytoreductive surgery to remove the cancer--may improve survival, but the value of the procedure remains controversial.

To determine whether systematic aortic and pelvic lymphadenectomy improves progression-free and overall survival, Pierluigi Benedetti Panici, M.D., of "La Sapienza" University in Rome, and colleagues conducted a clinical trial in which 427 patients with advanced ovarian cancer were randomly assigned to undergo either primary cytoreductive surgery followed by lymphadenectomy or cytoreductive surgery only. The patients were followed for an average of 68.4 months.

The 5-year progression-free survival rate was greater among patients treated with lymphadenectomy (31.2%) than among those who had only enlarged nodes removed (21.6%), and the duration of progression-free survival was also longer in the lymphadenectomy group (29.4 months versus 22.4 months). However, the 5-year overall survival rate and the median overall survival duration were similar in both groups. In addition, compared with the group that did not have lymphadenectomy, women who were treated with lymphadenectomy had a longer operating time, and more of these women required blood transfusions.

"This study found that 1) the addition of systematic lymphadenectomy t
'"/>

Contact: Sarah L. Zielinski
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
19-Apr-2005


Page: 1 2

Related medicine news :

1. Borderline personality disorder shows improvements with intensive psychotherapy
2. Quality improvement effort pays off in diabetes care
3. Implanting dopamine generators in brain cells obtains improvement in Parkinsons in monkeys
4. Exercise may lead to improvement in patients with Parkinsons
5. Home improvement warning -- Ladder-related injuries increasing in the US
6. Acute coronary syndrome therapy improvements linked with fewer deaths and improved clinical outcomes
7. Fiber-based light source promises improvements in food inspection
8. Chronic disease management quality improvement efforts yield better care delivery
9. Newer biomarkers add small improvement in cardiovascular risk prediction to established risk factors
10. New research shows big improvement in survival after stroke
11. Enbrel provides sustained clinical improvements for ankylosing spondylitis for up to 3 years

Post Your Comments:
(Date:7/23/2014)... The routine use of a molecular ... likelihood of performing the correct initial surgery for ... from the University of Pittsburgh Cancer Institute (UPCI), ... at the UPMC/UPCI Multidisciplinary Thyroid Center and other ... getting the correct initial surgery by 30 percent, ...
(Date:7/23/2014)... FL (PRWEB) July 23, 2014 Men ... pay higher premiums for life insurance based on national ... cheap life insurance rates search to its comprehensive tool ... at http://quotespros.com/life-insurance.html . , Providers that are ... selected, sorted and reviewed in one or two clicks. ...
(Date:7/23/2014)... near Sellafield or Dounreay since the 1990s are not ... research published in the British Journal of Cancer ... Research Group at the University of Oxford and from ... among those who were under 25 and living near ... in cancer incidence from 1991-2006 between those living near ...
(Date:7/23/2014)... New York, New York (PRWEB) July 23, 2014 ... that the use of a power morcellator ( http://www.injurybeacon.com/power-morcellator/ ... uterine sarcoma and other cancers throughout a woman’s body, ... on July 22nd in the Journal of the American ... hysterectomy using a power morcellator at 500 U.S. hospitals ...
(Date:7/23/2014)... Asking patients if a suspicious skin lesion is ... spot is likely to be cancerous, according to a ... the Department of Dermatology at Temple University School of ... Dermatology on July 23, 2014, found that nearly ... by itching, while 28.2 percent involve pain. Non-melanoma skin ...
Breaking Medicine News(10 mins):Health News:UPMC-Developed Test Increases Odds of Correct Surgery for Thyroid Cancer Patients 2Health News:UPMC-Developed Test Increases Odds of Correct Surgery for Thyroid Cancer Patients 3Health News:UPMC-Developed Test Increases Odds of Correct Surgery for Thyroid Cancer Patients 4Health News:Cheap Life Insurance Rates for Married Couples Added to Search System at Insurer Portal Online 2Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Publication of New Study Confirming Potential for Uterine Morcellation to Spread Undetected Cancer 2Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Publication of New Study Confirming Potential for Uterine Morcellation to Spread Undetected Cancer 3Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Publication of New Study Confirming Potential for Uterine Morcellation to Spread Undetected Cancer 4Health News:Research led by Temple's chair of dermatology: Pain and itch may be signs of skin cancer 2
(Date:7/23/2014)...  Lightlake Therapeutics Inc. ("Lightlake") (OTCQB: LLTP), a ... expertise in opioid antagonists, announced today that it ... with respect to its naloxone-based opioid overdose reversal ... has received an additional commitment from the National ... National Institutes of Health ("NIH"), to fund a ...
(Date:7/23/2014)... CITY, Calif. , July 23, 2014  Cardica, Inc. ... release financial results for its fiscal fourth quarter and year ... the markets close. Cardica,s management will host a conference call ... and provide an update on the company,s business. ... August 7, 2014, at 4:30 p.m. Eastern Time via phone, ...
(Date:7/23/2014)... Colo. , July 23 2014 Ampio ... of its new headquarters, manufacturing and research facility: ... CO 80112 Direct: (720) 437-6500 ... labor efficient, pharmaceutical drug manufacturing facility will be fully ... produce the first batches of Ampion TM necessary ...
Breaking Medicine Technology:Lightlake Therapeutics Inc. Files Investigational New Drug Application For Naloxone Nasal Spray For Reversing Opioid Overdose And Announces A Further Collaboration With The National Institute On Drug Abuse 2Lightlake Therapeutics Inc. Files Investigational New Drug Application For Naloxone Nasal Spray For Reversing Opioid Overdose And Announces A Further Collaboration With The National Institute On Drug Abuse 3Cardica to Announce Fiscal 2014 Fourth Quarter and Full Year Financial Results on Thursday, August 7, 2014 2Ampio Pharmaceuticals announces the opening of its new headquarters, manufacturing and research facility in Englewood Colorado 2
Cached News: