No link between short-term testosterone use and prostate cancer, ...( els of T and DHT. Prostate biopsies we...),Health

No prostate tissue changes attributable to testosterone therapy were found in this trial. Despite marked increases in serum testosterone levels, prostate levels of T and DHT (the hormone that stimulates prostate gland growth) did not change from baseline at 6-months. PSA, PV, tissue biomarkers and indices for atrophy and inflammation also were unchanged after 6-months of treatment. Furthermore, gene expression was not altered, cell proliferation was not accelerated, and histologic cancers were not increased. The study also showed testosterone therapy created positive effects in bones and muscles.

"The prostate appears to be buffered against rather wide fluctuations in serum testosterone levels," said Dr. Marks. "Still, all hypogonadal men considering testosterone therapy, especially older men, must be monitored closely by their physicians prior to and throughout treatment."

'"/>


21-May-2006