HOME >> MEDICINE >> NEWS
Notch signaling molecule important in type 2 immunity

(Philadelphia, PA) - Defects in immune system cells called T helper cells may lead to diseases characterized by a faulty inflammatory response such as autoimmunity and asthma. Understanding the molecular steps involved in how T helper cells mature may help researchers develop treatments for these diseases.

Helper T cells differentiate into two different types of cells Th1 or Th2 which are responsible for regulating immunity to different types of pathogens. Now, researchers at the University of Pennsylvania School of Medicine have shed light on a key molecular switch in this differentiation.

Notch is a protein that is a critical regulator of the process by which stem and other multipotent cells take on a specialized function, such as a T lymphocyte or a nerve cell in organisms ranging from fruitflies to humans. Using mice in which Notch signaling could be induced to turn off in mature T cells, the researchers showed that Notch signaling is an important determinant of whether an organism can mount an effective Th2 response. The mice lacking Notch signaling were unable to mount a protective Th2 cell response against infection by the gastrointestinal parasitic worm Trichuris muris. However, the mice did mount a healthy Th1 response to an infection by the intracellular parasite Leishmania major, showing that Notch signaling is specifically required for the Th2 arm of the immune system.

These findings indicate that regulating Notch signaling may have a therapeutic role in treating diseases caused by abnormally increased Th2 responses, such as asthma, autoimmunity, and some forms of inflammatory bowel disease. Drugs that inhibit Notch signaling, called gamma secretase inhibitors, are currently in clinical trials for T-cell leukemia and Alzheimer's disease. This study published in today's issue of the Journal of Experimental Medicine suggests that these drugs may be useful in treating diseases typified by increased Th2 responses.

Senior au
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
17-Oct-2005


Page: 1 2 3

Related medicine news :

1. Notch protein signaling directs early T-cell development
2. Flick of whiskers helps tease out brains shadow signaling system
3. Macrophage signaling may affect hormone resistance in prostate tumors
4. Scientists from the CIMA investigate a molecule for diagnosing hypertensive cardiopathy
5. Hybrid molecule causes cancer cells to self-destruct
6. Electric jolt triggers release of biomolecules, nanoparticles
7. Case and Cleveland Clinic researchers identify molecule in age-related macular degeneration
8. Researchers find molecule that may hold key to learning and memory
9. UCSF research pinpoints brain molecules role in developing addiction
10. Study identifies molecule essential for proper localization of blood stem cells
11. Research clarifies how brain replenishes memory-making molecules

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Notch signaling molecule important type immunity

(Date:5/22/2015)... VA (PRWEB) May 22, 2015 ... presented at the American Society of Clinical Oncology ... demonstrated improved survival rates for those patients who ... chemotherapy regimen of pemetrexed/cisplatin. Bevacizumab (Avastin® Genentech, Inc.) ... growth), and it is already routinely used to ...
(Date:5/22/2015)... 2015 Wimbledon Health Partners, the leading ... echocardiogram and NCV testing , is proud to ... All American National athlete, to the Wimbledon Athletics division. ... high level of testing and information it provides to ... athletic trainers, this way they can focus on the ...
(Date:5/22/2015)... 22, 2015 DMG Productions announces the ... to broadcast on Friday, May 29, 2015 at 7:30 ... , In this episode Innovations will explore Interstate Restoration, ... business quickly through disaster recovery and restoration. , Additionally, ... works collaboratively to develop and deliver training and education ...
(Date:5/22/2015)... 22, 2015 Ticket Down is a reputable ... Rangers NHL Eastern Conference Finals Tickets . All seating ... otherwise in the ticket listing. , For the first ... the top of the Eastern Conference. One of the original ... of ups and downs over the years, but the excitement ...
(Date:5/22/2015)... May 22, 2015 In an effort ... and Sons is offering to donate $5 dollars for ... AC unit or water softening system. Customers have their ... and Sons gets business; and the Special Olympics receives ... Special Olympics helps over 4.4 million athletes, and boasts ...
Breaking Medicine News(10 mins):Health News:Mesothelioma Research Organization Excited About Imminent Improvement to Standard of Care 2Health News:Wimbledon Athletics Recruits Team USA Athlete 2Health News:Wimbledon Athletics Recruits Team USA Athlete 3Health News:New Episode of Innovations Airing Friday, May 29, 2015 Via Discovery Channel 2Health News:Cheap Lightning vs Rangers NHL Eastern Conference Finals Tickets: Ticket Down Slashes Ticket Prices on New York Rangers vs Tampa Bay Lightning Eastern Conference Playoffs 2Health News:Cheap Lightning vs Rangers NHL Eastern Conference Finals Tickets: Ticket Down Slashes Ticket Prices on New York Rangers vs Tampa Bay Lightning Eastern Conference Playoffs 3Health News:Parker and Sons is Proud to Support the Special Olympics with Their Everybody Wins Program 2
(Date:5/21/2015)... Md. , May 21, 2015 ... open innovation competition designed to bring promising medical ... Heritage Provider Network (HPN) in collaboration with the ... for Advancing Innovation (CAI).  The winning teams were ... and live pitches and will move forward to ...
(Date:5/21/2015)... CITY, Calif. , May 21, 2015  Abaxis, ... manufacturing point-of-care blood analysis systems, announced today that ... investor relations, transitioning into the role of chief financial ... Stifel 2015 Dental & Veterinary Conference on Wednesday, May ... be held at The Peninsula Hotel in ...
(Date:5/21/2015)... , May 21, 2015 Frost & ... two-thirds of laboratories use commercial software or web-based ... represents uncaptured market share for suppliers. With 26 ... custom systems in-house, it is clear that various ... indicates that suppliers have a chance to gain ...
Breaking Medicine Technology:Neuro Startup Challenge selects 13 winning teams to launch startups for unlicensed NIH technologies to improve brain health 2Neuro Startup Challenge selects 13 winning teams to launch startups for unlicensed NIH technologies to improve brain health 3Neuro Startup Challenge selects 13 winning teams to launch startups for unlicensed NIH technologies to improve brain health 4Customers' Unmet Needs Create Opportunities for Laboratory Information Management System Suppliers to Transform the Industry 2Customers' Unmet Needs Create Opportunities for Laboratory Information Management System Suppliers to Transform the Industry 3Customers' Unmet Needs Create Opportunities for Laboratory Information Management System Suppliers to Transform the Industry 4
Cached News: