HOME >> MEDICINE >> NEWS
Novel treatment target for deadly brain tumors identified

WINSTON-SALEM, N.C. Researchers at Wake Forest University Baptist Medical Center have identified a second promising treatment target for glioblastoma multiforme, one of the most deadly types of brain tumors. The research results are reported in the October issue of Molecular Cancer Research.

"We've found that a particular protein may play a major role in the progression of these tumors, suggesting an attractive new treatment approach," said Waldemar Debinski, M.D., Ph.D., director of the Brain Tumor Center of Excellence at Wake Forest University Baptist Medical Center.

This was the first study to investigate the presence and significance of a protein called EphA2 in brain cancer cells. This protein, which is found in cell membranes, allows normal cells to communicate with their environment and each other. In its normal active state, the protein seems to inhibit abnormal cell growth and division.

Debinski and colleagues demonstrated that glioblastoma cells have significantly increased levels of the protein EphA2 compared to normal cells but it is in an inactive form. They believe that this inactive form of EphA2 aids in the survival and spread of cancer cells.

To test their hypothesis, they treated glioblastoma cells with ephrinA1, a naturally occurring molecule that binds to EphA2 and activates it. They had already demonstrated that ephrinA1 is present at much lower levels in cells and tumors with increased levels of inactive EphA2.

"We observed that cells treated with ephrinA1 slowed down their growth and were less likely to exhibit invasive properties," said Debinski.

The researchers believe that developing medication to change levels of EphA2 and ephrinA1 offers new promise for successfully treating glioblastoma multiforme, which is the most common form of brain tumor and the least curable of all human cancers. The majority of the 17,500 brain tumors diagnosed each year in the United States are glioblastomas
'"/>

Contact: Karen Richardson
krchrdsn@wfubmc.edu
336-716-4453
Wake Forest University Baptist Medical Center
31-Oct-2005


Page: 1 2 3

Related medicine news :

1. Novel candidate biomarker for heart failure also strongly predicts risk of death
2. Novel treatments may help alleviate constipation, IBS in women
3. Novel catheter technique successfully patches holes in the heart
4. Novel anti-oxidant and anti-inflammatory agent shows effectiveness on key endpoints in trial
5. Novel Ames Lab composite may replace depleted uranium
6. Novel computed imaging technique uses blurry images to enhance view
7. Novel brain areas associated with the recognition of gender, ethnicity and the identity of faces
8. Novel program enhances dementia caregivers quality of life
9. Novel gene therapy may lead to cure in hemophilia A patients
10. Novel therapy combinations gain ground in treating hepatitis
11. Novel stem cell technology leads to better spinal cord repair

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Novel treatment target for deadly brain tumors identified

(Date:11/23/2014)... Pro Ace Care, a renowned Vancouver hot ... be providing an 8 year warranty on its selected hot ... went up due to the impending winter season, it was ... the premium service that the company provides. As a result, ... John Wood and Bradford hot water tanks. , “Every ...
(Date:11/23/2014)... 23, 2014 (HealthDay News) -- The holidays can be ... sensory overload can trigger major meltdowns, an expert says. ... best of circumstances, but when you have children with ... an occupational therapy professor at University of the Sciences ... "It,s best to let your hosts or visitors know ...
(Date:11/23/2014)... 23, 2014 To show thanks to new ... collection of white evening dresses for weddings. Customers ... 24/7. , iFitDress.com is a distinguished dress manufacturer, and it ... by worldwide customers for a very long time. The CEO ... a customer will be able to buy not only a ...
(Date:11/23/2014)... AngelWeddingDress.com has recently updated its online store, offering ... “If you are looking for gorgeous beach wedding dresses ... Here you can enjoy 70% off discounts and all ... big marriage ceremony is the most important dream of ... is uppermost priority. Ophelia, one of customers, said, “I ...
(Date:11/23/2014)... VA (PRWEB) November 23, 2014 The ... Have in Common, **FDAnews On-Demand Webinar**, Dec. 11, 2014 ... , The FDA’s focus on promotional activities is ... , Now they're looking at websites, Twitter, journal ... the calendar for Thursday, Dec. 11, for On-Demand access ...
Breaking Medicine News(10 mins):Health News:Pro Ace Care Now Gives 8 Year Guarantee on Selected Vancouver Hot Water Tanks 2Health News:Holidays Can Be Sensory Overload for Kids With Autism 2Health News:iFitDress.com: Wonderful White Evening Dresses Now Available 2Health News:Beach Wedding Dresses Added to Outstanding Online Dress Company AngelWeddingDress.com 2Health News:FDAnews Announces The FDA is Watching: What Twitter, Tradeshows and TV Have in Common, On-Demand Webinar, Dec. 11, 2014 2Health News:FDAnews Announces The FDA is Watching: What Twitter, Tradeshows and TV Have in Common, On-Demand Webinar, Dec. 11, 2014 3Health News:FDAnews Announces The FDA is Watching: What Twitter, Tradeshows and TV Have in Common, On-Demand Webinar, Dec. 11, 2014 4Health News:FDAnews Announces The FDA is Watching: What Twitter, Tradeshows and TV Have in Common, On-Demand Webinar, Dec. 11, 2014 5
(Date:11/22/2014)... , Nov. 21, 2014  Particle Sciences, Inc ... has developed and manufactured a new innovative vaginal ... Research and Development arm of Exeltis Pharmaceuticals.  According ... Project Management at Particle Sciences, "This vaginal ring ... our material sciences and modeling expertise.  We are ...
(Date:11/21/2014)... Mass. , Nov. 21, 2014  Alere Inc. ... rapid diagnostic tests, has appointed Juliet Cunningham ... role, Cunningham will be responsible for driving communications with ... execute on a series of changes to increase shareholder ... progress to investors," said Namal Nawana, Chief Executive Officer. ...
(Date:11/21/2014)... , Nov. 21, 2014  Tandem Diabetes Care ... a medical device company and manufacturer of the ... partnership with Tidepool, a non-profit dedicated to improving ... software platform that increases diabetes data accessibility. This ... which is currently under development, to download and ...
Breaking Medicine Technology:Particle Sciences' Clinical Trial Supplies Group Manufactures Innovative Vaginal Ring 2Alere Appoints Juliet Cunningham to Lead Investor Relations 2Tandem Diabetes Care Announces Partnership with Tidepool to Further Expand Access to Diabetes Device Data 2Tandem Diabetes Care Announces Partnership with Tidepool to Further Expand Access to Diabetes Device Data 3
Cached News: