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Novel treatments may help alleviate constipation, IBS in women

rostone or placebo for 12 weeks and asked to rate their IBS symptoms. To be considered a monthly responder, patients had to report moderate relief four out of four weeks or significant relief two out of four weeks. Overall responders were defined as those who had been monthly responders two out of three months.

"The lubiprostone study demonstrates the continuing need for new and emerging therapies for IBS, especially for women," said Douglas A. Drossman, M.D., Co-Director, University of North Carolina Center for Functional Gastrointestinal and Motility Disorders in Chapel Hill, N.C., and lead author of the study. "We believe more research needs to be done to better determine lubiprostone's benefits and tolerability, but this study suggests people suffering from IBS and constipation may soon have another option for relief."

Dr. Drossman will present this study on Tuesday, May 22, at 11:45 a.m. in Room 151.

Effects of Novel, First-in-Class Guanylate Cyclase-C Activator, Linaclotide Acetate (MD-1100), on Gastrointestinal and Colonic Transit and Bowel Habits in Patients with Constipation-Predominant Irritable Bowel Syndrome (C-IBS) (Abstract #532)

Researchers are continually looking for unique pathways to treat digestive diseases, such as constipation and irritable bowel syndrome. Linaclotide is a novel therapy that works on a transmembrane protein in the lining of the gut called guanylate cyclase-C (GC-C). Specific gut hormones utilize GC-C to regulate intestinal fluid secretion. Linaclotide is unique in that it exerts its effect locally in the intestine while having minimal systemic exposure.

Thirty-six women suffering from IBS with constipation (IBS-C) were examined in a double-blind, placebo-controlled study, which consisted of a five-day baseline and a five-day treatment period. The endpoints were gastrointestinal transit and bowel function. Patients who received linaclotide experienced a significant
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Contact: Aimee Frank
AFrank@gastro.org
301-941-2620
American Gastroenterological Association
21-May-2007


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