Novel treatments may help alleviate constipation, IBS in women

acceleration of ascending colon emptying and overall colonic transit as well as a significant improvement in stool consistency, stool frequency, ease of passage and time to first bowel movement. The degree to which stool was loosened was strongly dependent on the dosage of linaclotide administered.

"Among the study participants, linaclotide was able to improve a range of bowel functions, which are typically impaired in patients with IBS-C," said Viola Andresen, M.D., of Mayo Clinic in Rochester, Minn., and lead author of this study. "Clearly additional studies are warranted, but we remain optimistic that this treatment may hold promise for people with constipation-predominant IBS."

Dr. Andresen will present this study on Monday, May 21, at 4 p.m. in Room 101.

Hypnotherapy for Children with Functional Abdominal Pain or Irritable Bowel Syndrome: a Randomized Controlled Trial (Abstract #914)

As hypnotherapy has demonstrated effectiveness in adults with IBS, researchers sought to compare its effects in children to standard medical therapy commonly used for the condition as an alternative to drug therapy.

The study involved 53 patients between eight and 18 years old with FAP or IBS, who were administered six half-hour hypnotherapy sessions over a three-month period. Endpoints were pain intensity, pain frequency and other symptoms, such as nausea, headache and appetite, which were recorded at baseline, one, two, and three months after randomization and six and 12 months after therapy. Researchers defined "cure" as those who experienced greater than 80 percent improvement in pain.

The study revealed that hypnotherapy was superior to conventional therapy for children with longstanding functional abdominal pain (FAP) or IBS, curing 59 percent of the patients, versus just 12 percent of patients who received conventional therapy. After one year, the figures were 85 percent and 25 percent, respectively.

Contact: Aimee Frank
American Gastroenterological Association

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