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Novel vaccine effective against middle ear infection in young children

se is most prevalent--children younger than two years.

Roman Prymula (University of Defence, Hradec Kralove, Czech Republic) and colleagues tested a vaccine containing proteins from 11 different strains of S. pneumoniae attached to a protein derived from H. influenzae. 4968 infants were randomly assigned to receive the pneumococcal protein D vaccine (intervention group) or hepatitis A vaccine (control group) at the ages of 3, 4, 5 and 12-15 months. The investigators followed up the children at the end of their second year of life and found that there were 333 cases of otitis media in the pneumococcal protein D vaccine group and 499 in the control group. They also found that using the vaccine not only protected against pneumocccal otitis media, but also against middle ear infection caused by H. influenzae.

Dr Prymula states: "We found a reduction in ear, nose and throat specialist-confirmed episodes of acute otitis media by about a third in infants in the vaccine group compared with controls."
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Contact: Joe Santangelo
j.santangelo@elsevier.com
212-633-3810
Lancet
2-Mar-2006


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